The risk for future cerebrovascular disease in pregnant women with Moyamoya disease: a nationwide population-based study in South Korea

Background: Physiologic changes during pregnancy affect the development of postpartum cerebrovascular disease (CVD) in women with Moyamoya disease. Due to the rare prevalence of Moyamoya disease and its large regional variations, large-scale based studies on the risk of CVD after delivery have not been conducted. This study aimed to evaluate whether women with Moyamoya disease have an increased risk of CVD after delivery. Methods: Research data was collected from the National Health Insurance Claims Database of the Health Insurance Review and Assessment Service. Patients who delivered in Korea from 2007 to 2014 were enrolled in this study. We classified women as having CVD if they were diagnosed with any of the following conditions between delivery and December 31, 2016; cerebral infarction (I63.X in the International Classification of Diseases-10th Revision [ICD-10]) and/or intracranial hemorrhage (I61.X, I62.X in ICD-10) and/or subarachnoid hemorrhage (I60.X in ICD-10). Women with Moyamoya disease were identified as having I67.5 in ICD-10. We matched the study cohort by the ratio of 1:10 to analyze the risk CVD occurrence. The matching technique applied in this study was based on the variables of age and parity. To evaluate the adjusted hazard ratio (HR) for CVD in women with Moyamoya disease, we used multivariate Cox proportional hazard regression. Results: Among a total of 3,611,216 Korean women who underwent delivered, we identified 412 women with Moyamoya disease diagnosis and 1420 age- and parity-matched women without Moyamoya disease (control). Compared to the control group, women with Moyamoya disease had a significantly higher rate of Cesarean section, overt DM, and essential hypertension (all p < 0.0001). Among women with Moyamoya disease, 55 (13.35%) women developed CVD within the follow-up postpartum period. The presence of Moyamoya disease was associated with an increased risk of CVD after delivery (adjusted HR 37.42; 95% confidence interval (CI) 17.50-80.02 within 2.3 years) after adjusting for pregnancy-induced hypertension, gestational diabetes mellitus, pregestational diabetes, chronic hypertension. Conclusion: This population based study showed that the occurrence rate of CVD after delivery was higher in women with Moyamoya disease than in those without. Therefore, careful and long-term postpartum surveillance is required for women with Moyamoya disease.ope

성공적인 분만 결과를 가진 무증상 임신후기 자궁감돈: 문헌 검토를 포함한 증례보고

An incarcerated gravid uterus is a rare obstetrical complication that requires close monitoring to ensure fetal and maternal well-being and to plan a successful delivery. Most patients present with vague anatomic pressure-related symptoms, such as pelvic discomfort and urinary symptoms, in the early 2nd trimester. Initial presentation in the 3rd trimester is scarce, and asymptomatic cases are even rarer. In this case report, we present an asymptomatic patient who was referred at 30 weeks of gestation with an initial impression of placenta previa totalis. She was not a candidate for uterine reduction; therefore, after a close follow-up period, she underwent planned cesarean section at 36 weeks of gestation. Because of its rare frequency and related obstetrical complications, early clinical suspicion and diagnosis are critical for management until delivery and establishing a successful delivery strategy.ope

인지질막과 Purothionin 과의 상호작용에 관한 연구

학위논문(석사) - 한국과학기술원 : 생물공학과, 1987.2, [ iii, 51 p. ]Purothionin was isolated from wheat and its binding behavior to crude PC/CL (4:1) vesicles was studied. This protein was found to bind to the vesicles at pH 4,5 as well as at pH 7. Its was found that the vesicle became permeable to carboxyfluorescein and terbium, entrapped within the vesicles, only when the purothionin is added to the system. Since, no fusion of the vesicles was observed under the condition, it appears that the binding of the purothionin to the vesicles is followed by the channel formation in the bilayer through which carboxyfluorescein and terbium leak rapidly.한국과학기술원 : 생물공학과