Uric Acid Level Has a J-Shaped Association with Arterial Stiffness in Korean Postmenopausal Women

Background: Uric acid has been reported to function both as an oxidant or antioxidant depending on the context. A previous study in the Korean population reported a positive linear association between serum uric acid level and arterial stiffness in men, but little is known about how serum uric acid level is related to the risk of increased arterial stiffness in Korean postmenopausal women. Methods: We performed a cross-sectional study of 293 subjects who participated in a health examination program run by the health promotion center of Gangnam Severance Hospital between October 2007 and July 2010. High brachial-ankle pulse wave velocity was defined as a brachial-ankle pulse wave velocity of more than 1,450 cm/s. The odds ratios (ORs) for high brachial-ankle pulse wave velocity were calculated using multivariate logistic regression analysis across uric acid quartiles after adjusting for other indicators of cardiovascular risk. Results: The 293 postmenopausal women were divided into quartiles according to uric acid level. The mean brachial-ankle pulse wave velocity values of each quartile were as follows: Q1, 1,474 cm/s; Q2, 1,375 cm/s; Q3, 1,422 cm/s; Q4, 1,528 cm/s. The second quartile was designated as the control group based on mean brachial-ankle pulse wave velocity value. Multivariate adjusted ORs (95% confidence intervals) for brachial-ankle pulse wave velocity across the uric acid quartiles were 2.642 (Q1, 1.095-6.3373), 1.00, 4.305 (Q3, 1.798-10.307), and 4.375 (Q4, 1.923-9.949), after adjusting for confounding variables. Conclusion: Serum uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausal women.ope

폐경 후 여성에서 C-반응단백과 악력의 연관성

배경 : 신체기능의 저하(Functional declining)와 신체수행능력 (Physical performance)의 저하는 장애나 사망과 매우 관련성 이 높다. 염증은 근육량(Muscle mass)과 근력(Muscle strength) 의 감소에 영향을 끼침으로써 신체수행능력의 저하를 가져올 수 있다. 여성에게 폐경기는 근력 등 신체변화가 급격히 일어나는 임상적으로 중요한 시기이다. 본 연구의 목적은 폐경 이후 한국 여성에서 염증과 근력의 관계를 알아 보는 것이다. 방법 : 2016-2017년 한국 국민건강 영양조사자료를 이용하여, 해당연도에서 1115명의 대상자를 선정하여 연구를 진행하였다. 근력은 악력을 이용하여 평가하였으며, 낮은 악력은 대상자 중 하위 25% 로 정의하였다. 대상자를 고감도 C-반응단백(High sensitivity C-Reactive protein, hs-CRP) 수치에 따라 4군으로 나누어 악력 저하의 위험도를 알아보고자 다중 로지스틱 회귀분 석(Multiple logistic regression analysis)을 이용하여 교차곱비 Odds Ratios(ORs)를 구하였다. 결과 : 나이, 체질량지수, 교육수준, 가계수입, 결혼, 신체활동, 흡연, 음주를 보정한 후에 가장 낮은 고감도 C-반응 단백 그룹 과 비교하여 가장 높은 고감도 C-반응 단백 그룹의 악력 저하 에 대한 ORs 값은 오른손 1.85 (95% Confidence Intervals : 1.05 – 3.27) 왼손 2.31 (95% Confidence Intervals 1.34 - 4.04) 이었다. 결론 : 폐경 이후의 한국 여성에서 고감도 C-반응 단백이 높을 수록 악력 저하의 위험도가 높았다. Background: Inflammation may contribute to adverse muscle health, which is a key factor in functional declining. Menopausal period is clinically important in which muscle health changes rapidly. The purpose of this study was to clarify the relation between high sensitivity C-reactive protein (hs-CRP) and muscle strength among Korean postmenopausal women. Methods: This study used data from the Korean National Health and Nutrition Survey (KNHANES) during the seventh term (2016-2017). A total of 1115 participants remained eligible for this study. Muscle strength was assessed using hand grip strength. Low hand grip strength was defined as the lowest 25% of study sample. After Participants were categorized into quartiles based on hs-CRP, the odds ratios (ORs) and 95% confidence intervals (CIs) for low hand grip strength according to hs-CRP quartile were calculated using multiple logistic regression analysis. Results: The results showed that hs-CRP was negatively associated with both hand-grip strength (OR = 1.85, 95% CI = 1.05 - 3.27, OR = 2.31, 95% CI = 1.34 - 4.04 for the highest quartile of hs-CRP group relative to the 1st quartile, right and left hand respectively) when adjusted for age, body mass index, cigarette smoking, alcohol ingestion, physical activity, household income, education level, and marital status. Conclusions: The results suggest that hs-CRP level was inversely and independently associated with low hand grip strength, suggesting it as a useful additional measure for assessing low hand grip strength, particularly in late postmenopausal women.open석