크론병 환자에서 Trichuris suis ova 치험 1예

Crohn's disease (CD) is one of the chronic inflammatory bowel diseases of unknown etiology. It may develop in any part of the gastrointestinal tract, with periods of remission and relapse of symptoms. The incidence of CD has increased rapidly during the past several decades. CD is generally treated with 5-aminosalicylic acid, steroids, immunomodulators such as azathioprine, and the monoclonal antibody for TNF-α known as infliximab. Patients with CD demonstrate immune dysregulation and excessive Th1 inflammatory response. Helminths induce strong Th2 immune responses that can inhibit or down-regulate the host Th1 immune response to unrelated, concomitant parasitic, bacterial, and viral infections. This response may be beneficial in CD, since recent studies have reported that Trichuris suis ova can be used as a therapeutic agent for CD. Trichuris suis is a porcine whipworm genetically related to Trichuris trichiura, the human whipworm. We report a therapeutic experience using Trichuris suis ova in a patient with CD.ope

탄소복합재 기반 에너지 저장시스템의 기술 및 시장 동향

비매품/무

Effects of Mosapride Citrate on the Motility of Stomach, Ileum and Colon in Conscious Guinea Pigs

Background/Aims: Mosapride citrate (Mosapride) is a relatively new selective 5-HT4 receptor agonist. Several studies have reported that mosapride selectively stimulates the upper GI motility, but not lower GI motility. However, 5-HT4 receptors are distributed in the stomach, small bowel and colon as well. In other studies, mosapride had a stimulatory effect on the lower GI tract. Therefore, we studied the effects of mosapride on the upper (stomach) and lower GI tract (ileum, proximal colon and distal colon) in conscious guinea pigs. Methods: We implanted force transducers into guinea pig`s stomach, ileum, proximal colon and distal colon. Mosapride (0, 1, 3, 10 and 30 mg/kg) was administered intragastrically through a polyethylene tube. The GI motor activity was measured by the motor index. After mosapride 10 mg/kg was administered intragastrically, atropine sulfate or GR113808 was administered intravenously. Results: Mosapride significantly stimulated the motor activities of the stomach, ileum and colon. The relative prokinetic potency of mosapride was not different among the 4 sites of the GI tract. The enhancing effect of mosapride was antagonized by atropine or GR113808, a selective 5-HT4 receptor antagonist. Conclusions: This study indicates that mosapride enhances both the upper and lower GI motility with similar potency by stimulation of the 5-HT4 receptor that is mediated by cholinergic neurons in a conscious guinea pig. Based on the possibility of obtaining similar results in humans, we suggest that mosapride may be useful for the treatment of upper and lower GI motor disorders.ope

Endoscopic evaluation of gastric emptying and effect of mosapride citrate on gastric emptying

PURPOSE: Gastric emptying has been evaluated by scintigraphy in spite of its limitations of time consumption, cost, and danger of radioisotope. Endoscopy is a simple technique, however, its validation for gastric emptying and quantification of food has not yet been investigated. The aim of our study was to assess endoscopic gastric emptying compared with scintigraphy and radiopaque markers (ROMs) studies. We also investigated the effect of a single dose of mosapride on gastric emptying. MATERIALS AND METHODS: Fifteen healthy volunteers underwent scintigraphy. Next day, subjects received a standard solid meal with ROMs and underwent endoscopy and simple abdomen X-ray after 3 hrs. After one week, the same procedure was repeated after ingestion of mosapride (5 mg for group 1, n = 8; 10 mg for group 2, n = 7) 15 min before the meal. Quantification of gastric residue by endoscopy was scored from 0 to 3, and the scores were added up. RESULTS: All subjects completed the study without any complication. The gastric emptying rate [T(1/2) (min)] was in normal range (65.6 +/- 12.6 min). Endoscopic gastric emptying was correlated significantly with gastric clearance of ROMs (r = 0.627, p = 0.012). Endoscopic gastric emptying and gastric clearance of ROMs after administration of mosapride showed significant differences in the 10 mg group (p < 0.05). CONCLUSION: Endoscopy can evaluate gastric emptying safely and simply on an outpatient basis. A 10 mg dose of mosapride enhanced gastric emptying, assessed by both endoscopy and ROMsope

Correlation between Clinical Symptoms and Radiologic Findings before and after Pneumatic Balloon Dilatation for Achalasia

Background/Aims: We investigated the risk factors for short-term recurrence and analyzed the correlation between subjective clinical symtoms and objective radiological findings in patients with achalasia undergoing pneumatic balloon dilatation. Methods: Twenty patients who were treated by pneumatic balloon dilatation were enrolled. We compared prospectively various indices before and after the treatment as follows: 1) Eckardt symptom score and dysphagia grade, 2) The ratio of the maximal width in mid-esophageal lumen to the minimal width in distal esophagus around lower esophageal sphincter, and 3) the percentage of maximum activity retained in the esophagus at 30 seconds and T½ in esophageal scan two days after the treatment. Results: 1) Clinical indices and radiologic indices significantly improved after pneumatic dilatation. 2) There was no significant correlation between the clinical indices and the radiologic indices before and after the treatment. 3) The difference percentage of clinical indices did not show significant correlation with the difference percentage of the radiologic indices. 4) Compared to the group above 20% in the difference percentage of 30 second residual fraction, the one below 20% had a four-fold risk in short-term recurrence. Conclusions: Clinical symptoms and radiologic indices significantly improve after pneumatic dilatation but have no significant correlation to each other. The group below 20% in the difference percentage of 30 second residual fraction has a high risk of recurrence and may need careful examination and early repeated pneumatic dilationope

탄소복합소재 지식연구회 (2차 회의)

행사명 : 2013년 제 2차 탄소복합소재 지식연구회 일 시 : 2013. 6. 11(화) 16:30~19:00 장 소 : 한국탄소융합기술원 국제탄소연구소 세미나실(2층) 참석대상 및 예상 인원 : 지식연구회 위원 30명 내외 주요내용 : - 주제발표(탄소재료 기반 부품개발 사례 및 시장전망), - 사업소개(한국탄소융합기술원 지원사업), - 정보교육(NDSL), 연구회 운영방안, 의견수

새로운 회화의 전개와 정립에 대한 연구

이 논문은 1960년을 전후하여 대두된 한국 현대 동양화에 있어서 「비구상」 회화의 근본 동기와 문제점을 찾아봄으로써, 그 정립의 가능성을 제시하려고 했다. 먼저 새로운 회화의 전개에 대한 사적인 고찰을 통해 그 상황과 필연성을 밝혔다. 거기에는 시대적인 배경에 따라 제 1세대와 제 2세대의 정신적 기조가 다르게 나타나고 있었다. 전통적인 동양화의 세계에서 길러진 제 1세대는 고유한 동양화의 세계에서 발전적으로 변모해 나가는 가운데 서구의 현대미술과 만나게 되었다. 반면에 「근대화」,「서구화」라는 시대적 상황 속에서 전통적인 동양화를 시작하여 바로 그 「서구」에 맞서야 했던 제 2세대는 처음부터 「갈등」을 내포하게 되었다. 결국 제 2세대의 정신적 기조는 갈등이었다. 「갈등」을 극복하는 길은 근본적으로 새로운 가치관을 설정해야 하는 것이다. 새로운 가치관 위에서만이 새로운 창조적인 동양화가 가능하다고 보며 이를 제 3세대의 정신적 기조로 삼았다. 새로운 가치관은 자아의 확립에서 이루어지는 것이므로, 제 3세대는 자아확립을 위한 탐구에서부터 출발해야 한다. 물론 제 3세대의 새로운 가치관이 어떻게 설정될 것인가는 이 논문이 제기하는 미지수의 과제이다.;This thesis purposes to suggest the possibility of the establishment of &amp;quot;&amp;quot;non-figuratif&amp;quot;&amp;quot; style in contemporary Korean painting. Especially it bases on the research of the motif and issues found since 1960&amp;apos;s. Above all, I tried to show the mode of existence of non-figuratif in the historical demension. Here I came to study it divided in three parts: non-figuratif in the previous age, non-figuratif in the following age, and non-figuratif in the coming age. I found the group of painters belonged to one age showed different aspects in their spiritual attitudes toward their works, from that found in the painters belonged to another age. The previous age which was cultivated on the old traditional painting, after its gradual development through some changes, came across modern arts in Europe. However, the following age, from its first beginning, had to face against &amp;quot;&amp;quot;the western&amp;quot;&amp;quot; in the middle of the historical present of &amp;quot;&amp;quot;modernization&amp;quot;&amp;quot; or &amp;quot;&amp;quot;westernization&amp;quot;&amp;quot;. Here, in the situation, they had to suffer a certain conflict. In the following age, the spiritual basis on which the painters were compelled to work may be summed up as &amp;quot;&amp;quot;conflict&amp;quot;&amp;quot;. We can conclude that the best way to solve the &amp;quot;&amp;quot;conflict&amp;quot;&amp;quot; is to establish the new aesthetic value. At the same time, we can say the new image of creative Korean painting is possible only with new aesthetic value. And I want to view it as the very spiritual basis of the third coming age. In third coming age ought to start on the very inquiry for &amp;quot;&amp;quot;self-establishment&amp;quot;&amp;quot; of an artist. Natural is the fact that new aesthetic value can be done only upon the &amp;quot;&amp;quot;self-establishment&amp;quot;&amp;quot; of an artist. What the aesthetic value of the third coming age will be like is the assignment dued to the coming age.I. 서론 1 II. 「비구상」의 개념 5 III. 사적 전개 13 A. 1945~1952 13 B. 1953~1959 14 C. 1960~1969 21 D. 1970년 이후 35 IV. 정신적 기조 40 A. 제1세대 41 B. 제2세대 55 C. 제3세대 66 V. 결론 71 참고문헌 73 연보 76 ABSTRACT 8