Development of active compounds for the improvement of muscle function and metabolic syndrome

DoctorThe advantageous effects of exercise on overall health make it advisable to identify the orally active agents that improve the effects of exercise. Decreased aerobic capacity and mitochondrial oxidative phosphorylation are commonly associated with reduced longevity. We examined whether myricetin which is known to prolong lifespan in C. elegans, impacts mitochondrial function. Supplementation of mice with myricetin significantly improved their aerobic capacity, as evidenced by their enhanced running distance and time. Additionally, treatment of C. elegans with myricetin significantly improved healthspan and lifespan. These effects were associated with an induction of genes for mitochondrial biogenesis and oxidative phosphorylation and were mainly explained by an myricetin-mediated reduce in PGC-1α acetylation through enhancing SIRT1 activity. These results demonstrate that myricetin enhances mitochondrial activity, possibly by promoting SIRT1 and PGC-1α, and increases the endurance of mice, highly suggesting that myricetin is an excellent potential agent that mimics exercise. Peroxisome proliferator-activated receptor alpha/gamma (PPARα/γ) agonist as regulators of glucose and lipid metabolism has increased interest in the development of synthetic ligands as potential candidate drugs for therapeutic intervention in the metabolic syndrome and type 2 diabetes. However, some PPARα/γ dual agonists are accompanied with unwished adverse effects, including body weight gain, and tissue failure. We screened PPARα/γ dual agonists in Prestwick library, amodiaquine was shown to activate the PPARα/γ. This study examined the effects of a novel PPARα/γ dual agonist, amodiaquine, on metabolic syndromes. Amodiaquine selectively induced the transcriptional activities of PPARα and PPARγ. Amodiaquine enhanced fatty acid oxidation and glucose uptake in vitro. In high fat induced mice and genetically obese/diabetic models ob/ob and KKAy mice, amodiaquine greatly ameliorate insulin resistance, hyperlipidemia and hepatic steatosis, without body weight gain. In addition, amodiaquine would inhibit atherosclerosis in vitro by attenuating vascular smooth muscle cells (VSMC) proliferation. We demonstrate that amodiaquine shows advantageous effects on lipid and glucose metabolism by concurrent induction of both PPARα and PPARγ. Our data suggest that amodiaquine would be a new drug against obesity and related metabolic syndromes. Taken together, these studies suggest that the myricetin is a novel agent as mimics exercise and the amodiaquine can serve as a potential drug for metabolic disorders

Myricetin improves endurance capacity and mitochondrial function by Activating SIRT1 and PGC-1alpha

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폐회로 MIMO시스템을 위한 송신파워제어기법에 관한 연구

학위논문(석사) - 한국정보통신대학교 : 공학부, 2008.2, [ vi, 50 p. ]Recently, together with a rapid growth of wireless communication service market, users`` demands are extended to wideband and high datarate communication such as high quality multimedia services. To satisfy such demands with limited communication resources like frequency bandwidth, employing of multiple input multiple output (MIMO) sys-tem which utilizes multiple antennas at the transmitter and the receiver is essential. The MIMO systems can be classified into two types: one is space time coding system which improves system error performance by exploiting the spatial diversity, namely, using multiple antennas, and the other is layered space time (LST) system that increases transmission data rate by transmitting multiple data streams over multiple antennas. Among them, vertical Bell labs layered space time (V-BLAST) system is getting momentum due to its capability to support high data rate. In such MIMO systems, increased radio frequency (RF) chains and corresponding complex signal processing are required by employing multiple antennas, and thus these may be important issues from the system implementation point of view. To decode signal from interferences caused by other signals, an accurate signal detection algorithm with high complexity is required at the receiver, especially in V-BLAST systems. Such increased receiver complexity leads to enlargement of mobile terminal size as well as large power consumption. For this reason, huge complexity must be avoided to provide a realistic feasibility of the system. Nevertheless, an increase in computational complexity is inevitable to improve system performance. In conventional open-loop systems, it is well known that maximum likelihood (ML) detection is optimal but has tremendous complexity. For instance, the receiver complexity increases exponentially with the number of transmit antennas, thus, it is hard to practically implement. On the other hand, in closed-loop systems, the system performance can be improved w...한국정보통신대학교 : 공학부

BI-SLOTTED TREE BASED ANTI-COLLISION PROTOCOLS FOR FAST TAG IDENTIFICATION IN RFID SYSTEMS

본 발명에 따른 RFID 시스템에서의 두 슬롯 트리 기반의 태그 인식 방법은, 상기 리더가 상기 태그들에게 n-1 비트의 질의를 송신하는 단계와, 상기 리더의 인식 거리에 존재하는 태그들이 상기 n-1 비트의 질의를 수신하고, 수신된 질의와 태그 아이디의 앞부분 n-1 비트가 일치하는지를 판단하는 단계와, 상기 판단 결과, 상기 일치하는 태그들은 상기 태그 아이디의 n번째 비트값에 따라 서로 다른 시간 슬롯을 이용하여 n+1번째부터 마지막 비트까지의 상기 태그 아이디를 상기 리더에 전송하는 단계와, 상기 리더가 상기 태그들로부터 서로 다른 시간 슬롯으로 수신한 상기 n+1번째부터 마지막 비트까지의 상기 태그 아이디를 이용하여 충돌 여부를 체크하고, 상기 체크 결과에 의거하여 상기 태그들의 태그 아이디를 인식하는 단계를 포함한다.이와 같이, 본 발명은 태그 응답에 아무런 부담을 주지 않고 리더의 질의를 줄여 태그와 리더간의 질의-응답 횟수를 줄일 수 있을 뿐만 아니라 태그의 인식 성능을 개선할 수 있다

Anti-parkinson's effect of Extract of Daphne genkwa and its Active ingradient

The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; or a functional food additive for preventing or alleviating a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the additive comprises genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; and a method for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the method comprises the step of administering the pharmaceutical composition.국

Composition Comprising Extract of Rhodotypos scandens as Active Ingradient

본 발명은 병아리꽃나무의 줄기를 유기용매로 추출하여 수득한 병아리꽃나무 추출물을 유효성분으로 포함하는 파킨슨병의 예방 또는 치료용 약학적 조성물 및 상기 병아리꽃나무 추출물을 유효성분으로 포함하는 파킨슨병의 예방 또는 개선효과를 나타내는 식품 첨가물에 관한 것이다. 본 발명의 병아리꽃나무 추출물은 별다른 부작용을 나타내지 않으면서도, 파킨슨병을 예방 또는 치료할 수 있으므로, 파킨슨병의 보다 안전한 치료에 널리 활용될 수 있을 것이다.ope

Pharmaceutical composition for preventing or treating neurodegenerative diseases comprising compounds isolated from daphne genkwa extract

본 발명은 팥꽃나무 추출물로부터 분리된 화합물인 겐콰닌 N(Genkwanine N) 또는 유안후아신(Yuanhuacine), 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경퇴행성 질환 예방 또는 치료용 약학적 조성물에 관한 것이다. 보다 구체적으로본 발명은 팥꽃나무의 유기용매 추출물로부터 분리된 Genkwanine N 또는 Yuanhuacine, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경퇴행성 질환의 예방 또는 치료용 약학적 조성물, Nurr1 기능 장애에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물, Nurr1 활성화 조성물 및 상기 Genkwanine N 또는 Yuanhuacine을 유효성분으로 포함하는 신경퇴행성 질환의 예방 또는 개선용 기능성 식품 첨가물에 관한 것이다. 본 발명의 팥꽃나무 추출물로부터 분리한 화합물은 천연물 유래 화합물로서 별다른 부작용을 나타내지 않으면서도, 신경손상에 의한 Nurr1 단백질 활성 억제를 회복시키는데 우수한 효과를 나타냄으로써 Nurr1 단백질의 활성 억제로 인해 유발되는 파킨슨병을 비롯한 신경퇴행성 질환을 예방 또는 치료할 수 있다.국