신장암에서 CXCL10이 혈관생성에 미치는 영향

Dept of Medical Science/석사Angiogenic process is complex and several factors are involved as a promoter or inhibitor in angiogenesis. Tumor can use the imbalance of pro- and antiangiogenic factors in progression. The CXC chemokine family is consisted of pro- or antiangiogenic factors. Recent studies revealed C-X-C motif chemokine 10 (CXCL10) as an anti-angiogenic factor in response to angiogenic factors like bFGF or VEGF. However, a role of CXCL10 in cancer and angiogenesis is unclear. Here, we investigated the role of CXCL10 on tumor angiogenesis and its mechanisms in renal cell carcinoma. CXCL10 inhibited proliferation and tube formation of HUVEC in a dose-dependent manner, while it did not affect in vitro tumor proliferation of renal cell carcinoma cells. Expression of CXCL10 was down-regulated in Caki-1, UMRC3 and UMRC6 cells. Overexpression of CXCL10 suppressed expression of angiogenic factors including HIF-1α, EGF, VEGFB, VEGFC, HGF, and MMP9 in Caki-1 cells. In vivo, restoration of CXCL10 expression suppresses tumor growth in renal cell carcinoma by suppressing tumor angiogenesis in xenografts. Our data suggest that targeting CXCL10 is a novel therapeutic option in renal cell carcinoma.ope

Perception on Nursing Practice of Total Care Service in Nursing Students

Purpose: This study aims to identify the factors that affect the expected frequency of performance and the importance in nursing practice of total care service recognized by nursing college students. Methods: This is a descriptive study. A self-administered questionnaire survey was conducted on 288 nursing students of E university and data was collected and analyzed using the SPSS program. Results: The average scores for the expected frequency of performance and the importance in nursing practice of total care service were 4.07±0.58 and 4.00±0.50 respectively. The expected frequency of performance was found to have a significantly positive correlation with the importance in nursing practice. Additionally, the factors that influenced the degree of recognition in the expected frequency of performance and the importance in nursing practice of total care service among nursing students were comfortable care and respiratory care, respectively. Conclusion: The major finding of this study shows a significantly positive correlation between the expected frequency of performance and the importance in nursing practice. These results suggest that effective and systematic education is needed on factors affecting the expected frequency of performance and the importance in nursing practice for nursing college students