The studies on glycogenolytic adrenergic receptor in rat liver

To evaluate the adrenergic receptors which mediate glycogenolysis of rat liver, glycogenolytic response to adrenergic agonists and antagonistic effects of ergotamine and propranolol against glycogenolytic response of epinephrine were investigated using liver perlusion method. The results are summarized as follow: 1. ~ arke d and dose-dependent increase of glucose in the perfusate were produced by ppinephrine and norepinephine but glycogenolytic response to isoprotererrol was not marked as to epinephrine and norepinephrine. 2. Glycogenolytic response to epinephrine was more inhibited by ergotamine than by propranolol. These results indicates that glycogenolytic response of rat liver to catechlamine are mediated by both of alpha- and beta-receptors but the alpha receptor seems to be predominan

Screening platform for assessing cellular and behavioral defects in Drosophila Melanogaster

For screening drugs or molecules that can modify disease pathophysiology of human disease or conduct drug screening, the use of appropriate in vivo model with low expenditure suitable for large-scale screening is essential. Drosophila Melanogaster, whose genome contain orthologs for 75% of human disease-related genes, offers a quantitative screening platform for assessing both cellular and behavioral defects that are thought to be representative of human diseases like Parkinson’s disease(PD), Huntington’s disease(HD) or amyotrophic lateral sclerosis(ALS). Here, we present the low cost screening analysis platform available for measuring cellular and behavioral defects in Drosophila. This platform can be adapted for the use of therapeutic target discovery process as an economic and powerful in vivo screening tool for the researchers