Mies van der Rohe의 `유리마천루계획안(1921-1922)`에서 나타나는 表面的 反射光의 表現性에 관한 연구

학위논문(석사)--서울대학교 대학원 :건축학과,1998.Maste

제5차 충남미래연구포럼 - VR,AR산업의 미래전망과 스마트관광(CNI세미나2017-090) (홍승모)

O 주 제 : VR,AR산업의 미래전망과 스마트관광 O 개 요 - 일 시 : 2017.07.21.(금) 13:00 - 장 소 : 디지털파빌리온(VR산업 현장견학) 누리꿈스퀘어(전문가세미나) - 주요내용 : 충남지역과 VR, AR산업의 접목모색(스마트관광을 중심으로) O 주제발표 - VR, AR산업의 미래전망과 스마트관광 (포스트미디어(주) 홍승모 대표이사)N/

High YAP and TEAD4 immunolabelings are associated with poor prognosis in patients with gallbladder cancer

Abstract Yes-associated protein (YAP) and TEA domain-containing sequence-specific transcription factors 4 (TEAD4) are essential components of the Hippo pathway. Abnormal regulation of the Hippo pathway contributes to the progression and metastasis of many cancer types. However, their clinicopathologic and prognostic significances have not been studied in gallbladder cancers. Here, we systematically evaluated the YAP and TEAD4 immunolabelings and their association with clinicopathologic characteristics and survival outcomes using 212 specimens of surgically resected gallbladder cancers. High YAP and TEAD4 immunolabelings were identified in 70 (33%) cases and were associated with infiltrative growth pattern, poor differentiation, perineural invasion, and advanced pT classification and AJCC stage. High YAP immunolabeling was significantly associated with high TEAD4 immunolabeling (p < 0.001). High immunolabeling levels of YAP or TEAD4 alone and the combined YAPhigh TEAD4high group were significantly associated with poor survival in both univariate (p < 0.001) and multivariate analyses (HR = 2.358; 95% CI, 1.369-4.061; p = 0.002). Therefore, the YAP and TEAD4 immunolabelings are associated with aggressive behavior of gallbladder cancers and may be useful as a prognostic indicator in patients with surgically resected gallbladder cancer. Keywords: Gallbladder; Hippo; TEAD4; YAP; cancer; immunohistochemistry; prognosis. ⓒ 2021 Scandinavian Societies for Medical Microbiology and Pathology

Effects of Soil Temperature on Biodegradation Rate of Diesel Compounds from a Field Pilot Test Using Hot Air Injection Process

본 연구의 목적은 실제 디젤유로 오염된 불포화 토양을 복원하기 위해 수행되었던 고온공기 주입 파일롯 테스트에서 토양온도 변화가 생분해 속도에 미치는 영향을 알아보고자 하는 것이었고, 이것을 토대로 현장 생분해 속도, 최적의 생분해 온도 및 1차 분해 속도 상수를 도출하고 총복원기간을 예측해 보았다. 실험은 과거 디젤유 누출 사고가 있었던 고농도 오염지역에 대해 토양의 온도별 현장 호흡률(in-situ respiration)을 약 10일 간격으로 측정하는 식으로 진행되었다. 적용된 복원공법은 고온공기를 주입/추출하여 1차적으로 오염된 디젤 성분을 휘발, 추출하고 이어서 토양의 잔열과 미생물 생분해를 이용하여 토양내 잔류 디젤을 제거하는 후속공정으로 이루어졌다. 토양온도 26~60oC 범위에서 산소소비속도는 2.2~46.3%/day 값을 보였고 32oC에서 가장 빠른 46.3%/day를 나타냈다. 산소소비속도를 기준으로 하여 계산한 0차반응 생분해 속도(biodegradation rate)는 6.5~21.3 mg/kg-day 이었고 역시 토양온도 32oC에서 최대값을 보였고 그 이전과 이후는 각각 감소된 값을 나타냈다. 주기적으로 측정된 현장호흡률을 바탕으로 계산한 1차 분해속도 k는 몇가지 온도 범위에서 즉, 0.0027 d-1(@32.8oC), 0.0013 d-1(@41.1oC) 그리고 0.0006 d-1 (@52.7oC) 이었다. 토양의 초기 TPH 농도 대비 목표 농도를 870 mg/kg으로 가정했을 경우 소요 복원기간은 2~9년 정도 소요되는 것으로 예측되었다

Post-resection prognosis of patients with hepatic epithelioid hemangioendothelioma

Purpose: Epithelioid hemangioendothelioma (EHE) is a rare borderline vascular tumor. This retrospective, single-center study evaluated the outcomes of hepatic resection (HR) in patients with hepatic EHE. Methods: Over the 10-year period from 2009 to 2018, 11 patients with hepatic EHE underwent HR, accounting for 0.1% of the 11,979 adults who underwent HR at our center. Diagnosis of hepatic EHE was confirmed by immunohistochemical staining for CD34, CD31, and factor VIII-related antigen. Results: The 11 patients included 9 females (81.8%) and 2 males (18.2%) with mean age of 43.5 +/- 13.6 years. Preoperative imaging resulted in a preliminary diagnosis of suspected liver metastasis or EHE, with 9 patients (81.8%) undergoing liver biopsy. No patient presented with abnormally elevated concentrations of liver tumor markers. The extents of HR were determined by tumor size and location from trisectionectomy to partial hepatectomy. All patients recovered uneventfully from HR. Five patients showed tumor recurrence, with 4 receiving locoregional treatments for recurrent lesions. The 1-, 3 -and 5-year disease-free survival rates were 90.9%, 54.5%, and 54.5%, respectively. Currently, all patients remain alive and are doing well. Univariate analysis on tumor recurrence showed that tumor size >_ 4 cm was significantly associated with tumor recurrence (P = 0.032), but tumor number >_ 4 was not related to (P = 0.24). Conclusion: Hepatic EHE is a rare form of primary liver tumor often misdiagnosed as a metastatic tumor. Because of its malignant potential, HR is indicated if possible. HR plus, when necessary, treatment of recurrence yields favorable overall survival rates in patients with hepatic EHE. [Ann Surg Treat Res 2021;100(3):137-143