Reactive 2-Quinolones Dearomatized by Steric Repulsion between 1-Methyl and 8-Substited Groups

Usual 1-methyl-2-quinolone (MeQone) derivatives are not reactive because of aromatic property in the heterocyclic ring. On the other hand, 8-substituted MeQones have been proved to be highly reactive, which is caused by steric repulsion between the 1-methyl and the 8-substituted groups. When 1-methyl-3,6,8-trinitro-2-quinolone was treated with potassium (or trimethylsilyl) cyanide, cyanation proceeded at the 4-position regioselectively as a result of cine-substitution. This reaction is initiated with addition of cyanide species, and the cyanoquinolone is formed by the protonation of the resultant anionic intermediate followed by elimination of nitrous acid. The high reactivity was maintained even when one of the nitro groups on the benzene moiety was replaced by a methyl group, which afforded corresponding cine-substituted products upon treatment with potassium cyanide

5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: Quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.

平成26年

Blow-up theoremの初等的証明

applicationIntroduction Let X be an imbedded closed submanifold of a complex analytic manifold Y, of codimension d, with normal bundle N_x. Let f: Ŷ→Y be the blow-up of Y along X, and let 〓=P (N_x) be the exceptional divisor in Ŷ, with normal bundle N_〓. Let g: 〓→X be the restriction of f to X, and let E=g*N_x/N_〓 be the universal quotient bundle on 〓=P(N_x). Then f*i*(x)=j*(C(E)Ug*(x)) for all x∈H*(X). We shall give an elementary proof of this formula by using the singular cohomlogy theory. A general formula of this one was given by D. Quillen in [Q].departmental bulletin pape

中国・日本・韓国における愚人譚の一類型比較

departmental bulletin pape

ヒノキチオールと亜鉛における抗真菌活性について

令和3年度関東近県SSH指定校合同発表会conference poste

Circadian rhythms of the L-ascorbic acid level in Euglena and spinach

application/pdfPlant defenses against photo-oxidative stress have been studied almost exclusively with respect to stress responses, and little is known about how non-enzymic antioxidants change under constant conditions without a time cue or an environmental stress. Here, we show that, in both the flagellated alga Euglena gracilis Z and the angiosperm Spinacia oleracea L., the potent antioxidant L-ascorbic acid (Asc) displays a circadian rhythm with a maximum at subjective midday, a physiological state reflecting that attained at noon under daily light/dark cycles. Thus, photosynthetic organisms can maximize antioxidant levels in anticipation of midday, when photo-oxidative stress is most severe. These results may partly explain the in-phase circadian UV-C resistance rhythm recently identified in the alga. However, the Asc, but not the resistance, rhythm wanes in continuous darkness. This suggests the presence of persistent circadian rhythms in the levels of other antioxidants in continuous darkness, which may account for the UV-C resistance rhythm. (c) 2006 Elsevier B.V. All rights reserved.journal articl

日本人母語話者の韓国語翻訳に現れる誤用傾向

departmental bulletin pape

朝鮮における中国小説の受容について : 『剪燈新話』の場合

departmental bulletin pape