日本の青年期研究(1)

Articledepartmental bulletin pape

Reformism as Social Education in the Progressive-Era Mass Magazines : Jane Addams in Ladies' Home Journal

研究ノートapplication/pdfdepartmental bulletin pape

Hemodynamic changes in neonates born to mothers with Graves' disease

Purpose: Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD. Methods: Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT3), free thyroxine (FT4), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life). Results: The TRAb-positive newborns had higher FT4 levels and CI on Day 5 (both p<0.05) and higher FT3 (p<0.05) and FT4 levels (p<0.01) and CI (p<0.01) but lower TSH levels (p<0.05) on Day 10 than the TRAb-negative newborns. The TRAb-positive newborns had significantly higher NT-proBNP levels on Days 5 (median 752 vs. 563 pg/mL, p=0.034) and 10 (median 789 vs. 552 pg/mL, p=0.002) than the TRAb-negative newborns. Conclusions: Hemodynamic changes in 1 neonates born to TRAb-positive mothers with GD resulted in a higher CI and NT-proBNP levels than in those with TRAb-negative mothers from postnatal days 5 to 10.journal articl

Bending Strength Evaluation of Sugi Timber

departmental bulletin pape

防衛行為による第三者の法益侵害について(一) : 違法性判断枠組についての解釈論的一考察

2002-12-25departmental bulletin pape

Compressive coding for multichannel audio signals using independent component analysis

conference pape

Illustration of the Simulation Results Used to Support Functionality of Retrogenes for One Case <i>(RBMXL1)</i>

<div><p>(A) Distribution of the number of disablements observed in 10⁵ simulations of the <i>RBMXL1</i> retrogene evolution under neutrality. The frequency distribution of stop codons is shown in white, and that of deleterious indels in black. All of the simulations showed at least one mutation disrupting the ORF (see text); simulations without stop codons all showed several frame-disrupting indels (the minimum number of such indels in each simulation is four).</p> <p>(B) Nonsynonymous (<i>N</i>_A) and synonymous (<i>N</i>_S) substitutions observed in 10⁵ simulations of neutral <i>RBMXL1</i> retrogene evolution (diamonds). The black square indicates the observed nonsynonymous and synonymous substitutions in the <i>RBMXL1</i> primate phylogeny.</p> <p>(C) Ratio of nonsynonymous to synonymous substitutions in 10⁵ simulations of <i>RBMXL1</i> retrogene evolution in the primate lineages. The arrow indicates the observed ratio of nonsynonymous to synonymous substitutions in the <i>RBMXL1</i> primate phylogeny.</p></div

Additional file 2: Table S3. of Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis

Quantitative genotypes for all 15,183 inferred CNV regions (CNVRs). chr represents the chromosome on which the CNVR is located, while start and end indicate the coordinates of the first respectively last CGH probe contained in the CNVR. length_kb is the estimated CNVR length in kilobases. CNV_detection_status indicates whether a CNVR contains only deletions (del), duplications (dup) or both (cnv) and eqtl_mapping indicates whether a given CNVR was detected in at least two individuals and was therefore used for cis-eQTL mapping (1) or not (0). The columns thereafter are the quantitative genotypes defined as an individual’s median log2-ratio of all CGH probes within a given CNVR. (XLSX 5415 kb

Evidence for Positive Selection on <i>PABP3</i> Codons

<p>The rectangles correspond to the different domains of the PABP1 protein: RNA poly(A)-tail-binding domains (vertical lines), RNA-binding domains (hatched), protein–protein interaction domain (white), and PABP homo-oligomerization domain (black). Positions of positively selected codons with high posterior probabilities (>0.95) are indicated by arrows.</p

Additional file 1: Figures S1 – S4 and Tables S1, S2, S4, S5. of Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis

Supplemental figures and tables on CNV calling and eQTL mapping. (DOCX 1151 kb