“Shohuhokku-Yushimasanjyurokugin” by Jinendo Horo : reprint and introduction

departmental bulletin pape

Resistance-to-Duty Converter

This paper shows a resistance to duty comverter formed of a comparator, an operational amplifier, a resistor, and capacitor. A relation between resistance and a duty has been checked.departmental bulletin pape

SC Circulation Type D/A Conversion Circuit

This paper shows the DA converter with improved not affected by the capacity mismatch.Error caused by the use of operational amplifiers is reduced, resolution is expected to be 8bit. Converter Operation is confirmed on SIMetrix.departmental bulletin pape

Inductance-to-Period Converter

This paper presents a novel converter between resistance and period. Error analysis shows that accuracy is proportional to the gain of operational amplifier. Operation of proposed converter is confirmed on SIMetrix of circuit simulator.departmental bulletin pape

SC Successive Approximation A/D Converter

This paper shows an improved A/D converter insensitive to capacitance mismatch. By using Operational amplifier, error caused by it is reduced and resolution is estimated to 14bits. Converter Operation is confirmed on SIMetrix.departmental bulletin pape

Voltage-to-Duty Ratio Convertor

In this paper, we describe an A / D conversion circuit for converting the duty ratio of a voltage from the Op-amp and resistor and capacitor. Converter operation is confirmed on SIMetrix.departmental bulletin pape

大量出血後に低Na血症を契機に診断したAcute sheehan’s syndromeの1例

第45回日本女性栄養・代謝学会学術集会＜一般口演4＞journal articl

幕末・明治期の横浜のフランス人企業家アルフレッド・ジェラールについて

application/pdfdepartmental bulletin pape

Summary of key residues' motion in active-site and nucleotide-binding pocket.

a<p>Key residue in bold shows different behavior compared to that in the cognate A:dTTP/T:dATP system.</p

“Gate-keeper” Residues and Active-Site Rearrangements in DNA Polymerase μ Help Discriminate Non-cognate Nucleotides

<div><p>Incorporating the cognate instead of non-cognate substrates is crucial for DNA polymerase function. Here we analyze molecular dynamics simulations of DNA polymerase μ (pol μ) bound to different non-cognate incoming nucleotides including A:dCTP, A:dGTP, A(syn):dGTP, A:dATP, A(syn):dATP, T:dCTP, and T:dGTP to study the structure-function relationships involved with aberrant base pairs in the conformational pathway; while a pol μ complex with the A:dTTP base pair is available, no solved non-cognate structures are available. We observe distinct differences of the non-cognate systems compared to the cognate system. Specifically, the motions of active-site residue His329 and Asp330 distort the active site, and Trp436, Gln440, Glu443 and Arg444 tend to tighten the nucleotide-binding pocket when non-cognate nucleotides are bound; the latter effect may further lead to an altered electrostatic potential within the active site. That most of these “gate-keeper” residues are located farther apart from the upstream primer in pol μ, compared to other X family members, also suggests an interesting relation to pol μ's ability to incorporate nucleotides when the upstream primer is not paired. By examining the correlated motions within pol μ complexes, we also observe different patterns of correlations between non-cognate systems and the cognate system, especially decreased interactions between the incoming nucleotides and the nucleotide-binding pocket. Altered correlated motions in non-cognate systems agree with our recently proposed hybrid conformational selection/induced-fit models. Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol μ: T:dGTP</p></div