Fracture toughness estimation of thin chemical vapor deposition diamond films based on the spontaneous fracture behavior on quartz glass substrates

This article is on the experimental estimation of the fracture toughness of thin diamond film deposited by the microwave plasma chemical vapor deposition method on a quartz glass substrate. Because of their differences in the coefficient of thermal expansion, diamond films on a quartz glass substrate suffer tensile stress at room temperature and show various kinds of spontaneous fracture behavior, reflecting the mechanical properties of the films. On the basis of detailed observation of cracking patterns and also measuring the residual stress with the aid of Raman spectroscopy, the fracture toughness of the film having thickness of around 1 μm has been estimated here satisfactorily without the help of any difficult microscopic experiment. The fracture toughness of the film of thickness 0.35 μm is found to be around half of that obtained with much thicker films.application/pdfjournal articl

Novel process for SiO_2/Si selective etching using a novel gas source for preventing global warming

A novel gas source replacing fluorocarbon feed gases has been developed for preventing global warming. The novel gas source was designed to generate fluorocarbon species from polytetrafluoroethylene by CO_2 laser ablation. The species generated from the gas source were introduced into an electron cyclotron resonance (ECR) plasma employing Ar gases. To characterize the gas source, CF_x (x=1–3) radical densities with and without plasmas were measured by infrared diode laser absorption spectroscopy. In the ECR plasma employing the novel gas source, CF_x (x =1–3) radical densities were estimated to be of the order of 10^12–10^13 cm^-3. The gas source has been applied to the selective etching of SiO_2 to Si using the ECR plasma. As a result, the etching characteristics by ECR plasma employing the novel gas source were equivalent to those by a conventional ECR plasma employing C_4F_8 gas. Therefore, this novel gas source is applicable to etching processes for preventing global warming.journal articl

学生ボランティアに感謝

一般雑誌記事 / Articlearticl

The Buildings of the Dormitory called `Seika Ryo` in the Matsubun Industry Co., Ltd. (1) The Present State of the Buildings for Lodgings

This article is a survey about the construction of old girl dormitory which the Matsubun industry Co., Ltd. owns. This report reports the present situation of the building of three lodgings ridges. In both buildings, an old state is approximately just left in the appearance. However, the inside is largelyrepaired, and the first floor is repaired by the warehouse, and the state of the old dormitory room is only left in the second floor of Building No. 3.departmental bulletin pape

<原著>新生児,乳児期早期の先天性心疾患に対する術前画像診断-特にエコー診断のみの妥当性と限界-

新生児,乳児期早期に開心術をせざるを得ない症例は複雑かつ重症例が多く,このような例には原則として心エコー診断にて適応と術式を決定してきた。今回この方針の妥当性と限界を検討した。'91年～96年に行なった小児開心術111例117回中,60日以内の23例23回を対象とし,手術成績,心エコー診断と実際の病態の相違,心エコー診断のみにて手術を行なったことが直接手術成績ヘ関与した程度を検討した。60日以内症例の手術成績は,薪生児18例中死亡11例,29-60日以内5例中死亡3例で,姑息術8例中死亡7例,根治術15例中死亡7例で死因は多彩,複合的であった。術前心エコー診断が術中所見と相違した例は5例で,うち2例は複雑かつ重症例で,正しく病態診断ができたとしても救命不能であったと考えられた。最終的に心エコー診断に問題があった例は心室中隔欠損症の1例での部位の問題,大血管転位症の2例での冠動脈走行の問題であった。なお心室中隔欠損症についてはその後心エコー診断能が向上し,全例正診している。2力月以上の94回の開心術では全例術前に心臓カテーテル検査,および心血管造影を行なっており,手術死亡,病院死亡ともなかったことから60日以内例でも同様な検査は望ましいが,実際上症例によっては過大侵襲となる可能性は依然として存在している。以上から当面,(1) 心室中隔欠損例ではエコー診断を中心とする,(2) 大血管転位例では可能な限り心臓カテーテル検査および心血管造影を行い,とくに冠動脈の走行を確認する,(3) 複雑心奇形例では当面特殊例を除き,より詳細に心エコー診断を行い,心臓カテーテル検査や心血管造影は最小限に止める方針が妥当と思われた。journal articl

Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites

Exposure to chiral polychlorinated biphenyls (PCBs) has been associated with neurodevelopmental disorders. Their hydroxylated metabolites (OH-PCBs) are also potentially toxic to the developing human brain; however, the formation of OH-PCBs by human cytochrome P450 (P450) isoforms is poorly investigated. To address this knowledge gap, we investigated the atropselective biotransformation of 2,2′,3,4′,6-pentachlorobiphenyl (PCB 91), 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95), 2,2′,3,3′,4,6′-hexachlorobiphenyl (PCB 132), and 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) by different human P450 isoforms. In silico predictions with ADMET Predictor and MetaDrug software suggested a role of CYP1A2, CYP2A6, CYP2B6, CYP2E1, and CYP3A4 in the metabolism of chiral PCBs. Metabolism studies with recombinant human enzymes demonstrated that CYP2A6 and CYP2B6 oxidized PCB 91 and PCB 132 in the meta position and that CYP2A6 oxidized PCB 95 and PCB 136 in the para position. CYP2B6 played only a minor role in the metabolism of PCB 95 and PCB 136 and formed meta-hydroxylated metabolites. Traces of para-hydroxylated PCB metabolites were detected in incubations with CYP2E1. No hydroxylated metabolites were present in incubations with CYP1A2 or CYP3A4. Atropselective analysis revealed P450 isoform-dependent and congener-specific atropselective enrichment of OH-PCB metabolites. These findings suggest that CYP2A6 and CYP2B6 play an important role in the oxidation of neurotoxic PCBs to chiral OH-PCBs in humans

Synthesis and Activity of Substituted 2-Phenylquinolin-4-amines, Antagonists of Immunostimulatory CpG-Oligodeoxynucleotides^†

Fifty-seven 2-phenylquinolines substituted at the phenyl group and C4 of the quinoline were synthesized and analyzed for inhibition of the immunostimulatory effect of oligodeoxynucleotides with a CpG-motif. The Fujita-Ban variant of the classical Free-Wilson analysis gave a highly significant correlation for a series of 48 relatively small molecules demonstrating that (i) the partial contributions of substituents to biological activity (EC50) are additive and (ii) assuming similar bioavailability for all quinolines studied, the larger molecules cannot be accommodated within a still unknown biological receptor. The results suggest interaction of a basic antagonist molecule with weakly acidic groups in the antagonist−receptor complex. N-[2-(Dimethylamino)ethyl]-2-[4-(4-methylpiperazino)phenyl]quinolin-4-amine (50) is the most effective antagonist found in this study (EC50 = 0.76 nM)

平成26年度教育関係共同利用拠点シンポジウム「船で学び，海に学ぶ～共同利用拠点勢水丸の航跡～」

application/pdfThis symposium, “learning in the ship and from the sea - Track of SEISUIMARU authorized as interuniversitycommon-use educational center -”, was held on December 12, 2014. The purpose of thesymposium is to review the past activities of the center, and to examine the future work andimprovement. Many students, professors and staff belong to the Faculty of Bioresources, Mie Universityparticipated in the symposium. Educational programs were presented by professors of Nagoya University,Yokkaichi University and Mie University. Finally, the prospects for SEISUIMARU were discussed.departmental bulletin pape

Table_2_Antitumoral Effect of Plocabulin in High Grade Serous Ovarian Carcinoma Cell Line Models.xlsx

Ovarian cancer (OC) is a life-threatening tumor and the deadliest among gynecological cancers in developed countries. First line treatment with a carboplatin/paclitaxel regime is initially effective in the majority of patients, but most advanced OC will recur and develop drug resistance. Therefore, the identification of alternative therapies is needed. In this study, we employed a panel of high-grade serous ovarian cancer (HGSOC) cell lines, in monolayer and three-dimensional cell cultures. We evaluated the effects of a novel tubulin-binding agent, plocabulin, on proliferation, cell cycle, migration and invasion. We have also tested combinations of plocabulin with several drugs currently used in OC in clinical practice. Our results show a potent antitumor activity of plocabulin, inhibiting proliferation, disrupting microtubule network, and decreasing their migration and invasion capabilities. We did not observe any synergistic combination of plocabulin with cisplatin, doxorubicin, gemcitabine or trabectedin. In conclusion, plocabulin has a potent antitumoral effect in HGSOC cell lines that warrants further clinical investigation.</p