<Case Report> Three Indonesian Cases of Intraperitoneal Development of Metastatic Hepatocellular Carcinoma, Possibly Disseminated by Spontaneous Tumor Rupture

Abstract: We report 3 Indonesian patients with intraperitonial tumor development possibly caused by spontaneous rupture of hdpatocellular carcinoma (HCC). Each case presented with expansively growing nodular metastatic tumors and all nodules were surgically removed in each case. The first case upderwent lateral segmentectomy in Shanghai, while the second and third cases underwent liver resection for primary HCC in YMU hospital. Although the first case had seven intraperitoneal tumors, ranging from approximately 1 to 6 cm in maximal diameter, together with skin metastasis, the other two cases had a large solitary tumor, covered by the greater omentum; the tumors measured 6.5 cm and 13 cm in maximal diameter, respectively. In the third case, there were no intrahepatic metastases detected. Since this kind of recurrence pattern is very rare among Japanese HCC patients, we report these 3 cases and discuss the present findings on the distribution of HCC recurrence patterns in Japan.journal articl

Observation of B0→D*-(5π)+, B+→D*-(4π)++ and B+→D̅*0 (5π)+

journal articl

menziesii

near Wenassagebrush scablandSagebrus

glauca

Salix glauca Linnaeusgrey-leaved willow;grey willow;arctic grey willow;smooth willow;glaucous willowsaule glauqueMackenzie District, south side of Slave River, 8 miles above Ring Lake.Among Populus tremuloides and bordering natural clearingsDAO - Plante Exsiccatae. Shrubs 4 to 8 ft. in height

Fundamental and Third Harmonic Operation of SIT Inverter and its Application to RF Thermal Plasma Generation

The purpose of this paper is to study the 3rd harmonic operation of a voltage source inverter power supply. A static induction transistor (SIT) inverter power supply is used in this experiment. This power supply can generate 14 kW in steady state operation and its upper limit frequency of the gate driver is 1.7 MHz. The advantage of the 3rd harmonic operation is that the RF power at higher frequency range beyond the switching limit can be generated. It should be also noted that the driver circuit needs no special modification for this operation. The conversion efficiency and maximum output power are investigated as a function of output frequency. The conversion efficiency with harmonic operation is a little lower than the conversion efficiency with fundamental operation. At the frequency of <3 MHz, the conversion efficiency is higher than that of conventional linear amplifiers when using this SIT inverter power supply.journal articl

The Effect of COVID-19 on the Transit System in Two Regions: Japan and USA

The communication revolution that happened in the last ten years has increased the use of technology in the transportation world. Intelligent Transportation Systems wish to predict how many buses are needed in a transit system. With the pandemic effect that the world has faced since early 2020, it is essential to study the impact of the pandemic on the transit system. This paper proposes the leverage of Internet of Things (IoT) devices to predict the number of bus ridership before and during the pandemic. We compare the collected data from Kobe city, Hyogo, Japan, with data gathered from a college city in Virginia, USA. Our goal is to show the effect of the pandemic on ridership through the year 2020 in two different countries. The ultimate goal is to help transit system managers predict how many buses are needed if another pandemic hits.conference pape

D. Andreae de Barulo ... Commentaria super tribus postremis libris codicis nunc primum in lucem edita ex manuscripto bibliothecae Regentis Fornarij : cum summariis et indice rubricarum rerumque omnium locupletissimo

Mode of access: Internet.Colofón.Marca tipográfica en port.Port. a dos tintas.Sign: a-b8, A-X8, Y

In Situ Hybridization of ɛy and βmaj/min transcripts in WT and <i>p^100H</i> Mutant Mice at 14.5 dpc

<div><p>Expression of ɛy globin (A–D) and β globin (E and F) in sagittal sections of 14.5-dpc fetuses is shown in pseudocolor (red).</p><p>(A) WT fetus.</p><p>(B) <i>p^100H</i> Homozygous mutant fetus.</p><p>(C and D) Inset boxes are shown. Prominent expression of ɛy globin is only detected in the liver of mutant mice.</p><p>(E and F) In contrast, both WT and mutant mouse livers express adult βmaj/min, respectively. No signals were detected above background using sense probes (unpublished data).</p><p>The size bars represent 1 mm for (A) and (B); 100 μm for (C–F).</p></div

Expression Pattern of Sox6 by Northern Blot and In Situ Assays

<div><p>(A) Sox6 expression during embryonic development shown by Northern blot. Each lane contains 20 μg of total RNA from embryos whose ages are listed above each lane as dpc. The filter was hybridized with a ³²P-labeled 575-bp mouse Sox6 cDNA fragment (nucleotides 1353–1927). Numbers on the left are sizes of standard marker fragments in kb.</p><p>(B) Sox6 expression shown by in situ hybridization. Panel i: Sagittal section through an E12.5 mouse embryo using antisense Sox6. mRNA distribution is represented by pseudocolored red signal superimposed on the counterstained specimen. Sox6 transcripts are detected primarily in the fetal liver, developing nervous system, chondrocytes and craniofacial area. Panel ii: The sense control probe shows no signal above background. Panel iii: E7.5 embryo hybridized to antisense probe for Sox6. No signal is detected above background specifically in blood islands (or with the sense probe, unpublished data).</p><p>The size bars represent 100 μm.</p></div

Analysis of the Minimal Region (36 bp) of the Proximal ɛy Promoter Responsive to Sox6

<div><p>(A) The sequence of the 36-bp fragment and its mutant versions used in EMSA. The WT 36-bp DNA sequence (−63 to −28) of the ɛy globin proximal promoter contains two Sox/Sox6 consensus binding sites, shown in bold underline. Versions with truncation of this sequence (M1) or mutation of one of the two consensus binding sites (M2 and M3) are also shown.</p><p>(B) EMSA with c-Myc-tagged Sox6. EMSA was performed using the 36-bp radio-labeled WT probe (as shown in (A)) and c-Myc tagged Sox6 translated in vitro using reticulocyte lysate (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020014#s4" target="_blank">Materials and Methods</a>). Lane 1: radio-labeled free probe (run out of the gel); Lane 2: no competition, no antibody; Lane 3: competition with 200-fold excess cold probe, no antibody; Lane 4: no competition, c-Myc antibody (producing a supershift); Lane 5: no competition, Sox6 antibody (producing a supershift); Lane 6: no competion, no antibody using in vitro translated vector containing c-Myc, but not Sox6.</p><p>(C) EMSA with HA-tagged Sox6. EMSA was performed similarly as in (B) using HA-tagged Sox6 translated in vitro. Lane 1: radio-labeled free probe (run out of the gel); Lane 2: no competition, no antibody; Lane 3: competition with 200-fold excess cold probe, no antibody; Lane 4: no competition, HA antibody (producing a supershift).</p><p>(D) EMSA using MEL cell nuclear extracts and the 36-bp WT probe. Lane 1: radio-labeled free probe (run out of the gel); Lane 2: no competition, no antibody; Lane 3: competition with 200-fold excess cold probe, no antibody; Lane 4: no competition, Sox6 antibody (producing a supershift).</p><p>(E) EMSA with c-Myc-tagged Sox6, WT and mutant versions of the 36-bp fragment in competition. EMSA was performed using the radio-labeled 36-bp WT probe and the c-Myc tagged Sox6 translated in vitro<i>.</i> Lane 1: radio-labeled free probe; Lane 2: no competition, no antibody. Competition was performed using 200-fold excess cold probes corresponding to WT (Lane 3), M1 (Lane 4), M2 (Lane 5), and M3 (Lane 6).</p><p>(F) Both consensus Sox/Sox6 binding sites are required for Sox6 responsiveness. GM979 cells were transfected with a reporter construct (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020014#pgen-0020014-g002" target="_blank">Figure 2</a>A) containing −63 to +45 of the ɛy proximal promoter together with the CMV-Sox6 overexpression vector. Mutations of the consensus binding sites were also tested (M3, M2, M2 plus M3, see (A)). The fold repression of Sox6 with the WT or mutant constructs is shown. The baseline activities of the mutagenized reporter constructs are comparable to the WT construct.</p></div