Queen Mab : その後の作品への反映

application/pdf大阪府立大学紀要（人文・社会科学）. 1998, 46, p.35-44departmental bulletin pape

タマホマチ リョクナイショウ ジッタイ チョウサ ゼンコク 7チク リョクナイショウ エキガク チョウサ ノ イッカン トシテ

原発開放隅角緑内障,低眼圧緑内障等は無自覚で進行するため,病院統計ではその実態の把握が困雑であり,住民検診の必要がある。今回われわれは,全国規模で行なわれた緑内障住民検診の一環として,玉穂町住民40歳以上を対象に検診を行なった。その結果,一次検診では対象者1639人のうち1249人が受診して,受診率は76.2%であった。一次検診で,問診,屈折,矯正視力,眼圧,細隙灯,隅角,眼底撮影等の検査を実施し,この調査のための全国統一基準により,ニ次検診対象者147人を選択した。二次検診は,受診者は133人で,受診率は90.5%であった。二次検診では,眼圧,隅角,視神経乳頭の精査のほか,全員に視野検査を実施した。その結果,統一の診断基準により,85人(155眼)が高眼圧症を含め,緑内障およびその疑いと診断された。病型別では,低眼圧緑内障,原発開放隅角緑内障,原発閉塞隅角緑内障の順で,特に,低眼庄緑内障の緑内障全体に占める割合は,66.7%と従来の報告と比べ高率であった。玉穂町の緑内障頻度は2.72%で,病型別では,低眼圧緑内障1.80%,原発開放隅角緑内障0.48%,原発閉塞隅角緑内障0.36%,水晶体嚢性緑内障0.08%,高眼圧症0.84%であった。また,高齢になるほど緑内障の頻度は高くなることが示された。今回の調査では3人(6眼)を除きほとんどすべてが新規発見眼であり,多数の潜在患者の存在が推定される。本稿では,玉穂町における緑内障疫学調査の結果を示し,問題点に対して考察を加えた。journal articl

Measurement of the e+e-→D(*)+D(*)- cross sections

journal articl

Regulation of Tumor Metastasis by Ganglioside GD1a in Mouse Osteosarcoma FBJ Cells

application/pdfdepartmental bulletin pape

き裂エネルギー密度による安定成長き裂の破壊抵抗評価 (第6報, 平面ひずみ形破壊への適用)

The objective of the present study is to propose a practical method to evaluate the fracture resistance of a stably growing crack by crack energy density and to verify its applicability. The 1st report proposed the method, and the 2nd to 5th reports showed its applicability to the ductile crack in the thin plate. The present report shows the applicability to a plane-strain fracture in a thick board by inspecting the correspondence of the evaluated fracture resistance to the fracture mode change and the J-integral. Based on a stable growing crack test with 25% side-groove CT specimens, we get the expected result: (1) The evaluated fracture resistance by the crack energy density becomes constant, corresponding to the stable crack growth with a uniform plane-strain fracture mode observed by SEM. (2) The additional rate of the crack energy density agrees with the variable rate of the J-integral to the crack growth.journal articl

Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients

While tacrolimus and everolimus have common metabolic pathways through CYP3A4/5, tacrolimus is metabolized solely by CYP3A4 in recipients with the CYP3A5*3/*3. The purpose of this study was to evaluate how the area under the blood concentration-time curves (AUC) of tacrolimus could be predicted based on CYP3A5 genotype and the AUC of everolimus in renal transplant patients taking both drugs. The dose-adjusted AUC (AUC/D) of tacrolimus and everolimus were calculated at one month and one year after transplantation. Significant correlations between the AUC/D of tacrolimus and everolimus were found for patients with the CYP3A5*1 allele or CYP3A5*3/*3 at both one month and one year. At both stages, the determination coefficients were higher and the slopes of regression equations were larger for patients with CYP3A5*3/*3 compared to the CYP3A5*1 allele. A good correlation between single doses of tacrolimus and everolimus was found for CYP3A5*3/*3 patients at 1 year after transplantation (r = 0.794, p < 0.001). The variability of the AUC0–24/D of tacrolimus for each CYP3A5 genotype could be predicted based on the AUC0–12/D of everolimus. Clinicians may be able to comprehensively carry out the dose adjustments of tacrolimus and everolimus based on relationship with AUCs of both drugs in each CYP3A5 genotype