新規インフルエンザ特効薬2

平成20年6月14日（土）15日（日） 国立京都国際会館 開催textapplication/pdfconference objec

リサイクル型SECによるチオシアロシド糖鎖の精製《マイレビュー》

An efficient separation between fully acetylated thiosialoside methyl esters and fully acetylated Neu5Ac2en methyl esters was accomplished by means of the SEC method. Purity and structural elucidation of the isolated compounds were performed by a combination of elemental analyses and spectroscopic analyses, including IR, 1H, and 13C NMR, and mass spectroscopic analyses.textapplication/pdfdepartmental bulletin pape

Synthesis of glycoconjugate polymer carrying globotriaose as artificial multivalent ligand for Shiga toxin-producing Escherichia coli O157 : H7

http://www.sciencedirect.com/science/journal/01448617 | http://www.sciencedirect.com/science/journal/01448617As an artificial ligand, a glycoconjugate polymer carrying carbohydrate moiety of lactosyl ceramide or globotriaosyl ceramide (Gb3) was synthesized. Gb3 is known as the receptor of Shiga toxin-producing Escherichia coli O157: H7. The preparation of the glycoconjugate polymer initially involves the construction of the carbohydrate moiety of Gb3 derivative which has n-pentenyl group as polymerizable group. In addition, the n-pentenyl group of the Gb3 derivative was modified and different polymerizable groups such as acrylamide group were introduced at ω-position of the aglycon. Radical polymerization of the synthesized glycosyl monomers with or without acrylamide proceeded smoothly in water using ammonium persulfate and N, N, N′, N′-tetramethylethylenediamine as usual initiator system and gave water-soluble glycoconjugate polymers having various polymer compositions. These polymers have the potential to neutralize Shiga toxin by reason of cluster effect and multivalency.textapplication/pdfjournal articl

タミフル耐性インフルエンザウィルス阻害剤の基礎研究

４ 若手研究及び基礎研究textapplication/pdfresearch repor

タミフル耐性インフルエンザウィルス阻害剤の基礎研究

プロジェクト番号 : A06-605textapplication/pdfconference objec

Regioselective Synthesis of Methylated β-Cyclodextrins Leaving Hydroxy Groups

http://www.sciencedirect.com/science/journal/00404039 | http://www.sciencedirect.com/science/journal/00404039A series of methylated b-cyclodextrins (CDs) regioselectively leaving one or two hydroxy groups were prepared, and fluorescence spectroscopic measurements showed that they have unique binding characteristics against 2-p-toluidinylnaphthalene-6-sulfonate as a guest molecule in aqueous solution.textapplication/pdfjournal articl

タミフル耐性インフルエンザウィルス阻害剤の基礎研究 (II)

3 若手研究及び基礎研究textapplication/pdfresearch repor

新規インフルエンザ特効薬1

平成20年6月14日（土）15日（日） 国立京都国際会館 開催textapplication/pdfconference objec

Hydrometeorological behaviour of pine and larch forests in eastern Siberia

Seasonal changes in the water and energy exchanges over a pine forest in eastern Siberia were investigated and compared with published data from a nearby larch forest. Continuous observations (April to August 2000) were made of the eddy-correlation sensible heat flux and latent heat flux above the canopy. The energy balance was almost closed, while the sum of the turbulent fluxes sometimes exceeded the available energy flux (Rn-G) when the latent heat flux was large; this was related to the wind direction. We examined the seasonal variation in energy balance components at this site. The seasonal variation and magnitude of the sensible heat flux (H) was similar to that of the latent heat flux (λE), with maximum values occurring in mid-June. Consequently, the Bowen ratio was around 1.0 on many days during the study period. On some clear days just after rainfall, λE was very large, and the sum of H and λE exceeded Rn-G. The evapotranspiration rate above the dry canopy from May to August was 2.2 mm・day^-1. The contributions of understory evapotranspiration (Eu) and overstory transpiration (Eo) to the evapotranspiration of the entire ecosystem (Et) were both from 25 to 50% throughout the period analyzed. These results suggest that Eu plays a very important role in the water cycle at this site. From snowmelt through the tree growth season (23 April to 19 August 2000), the total incoming water, comprised of the sum of precipitation and the water equivalent of the snow at the beginning of the melt season, was 228 mm. Total evapotranspiration from the forest, including interception loss and evaporation from the soil when the canopy was wet, was 208-254 mm. The difference between the incoming and outgoing amounts in the water balance was from +20 to -26 mm. The water and energy exchanges of the pine and larch forest differed in that λE and H increased slowly in the pine forest, while λE increased rapidly in the larch forest and H decreased sharply after the melting season. Consequently, the shape of the Bowen ratio curves at the two sites differed over the period analyzed, as a result of the differences in the species in each forest and in soil thawing.journal articl

タミフル耐性インフルエンザウィルス阻害剤の基礎研究(II)

プロジェクト番号 : A07-96textapplication/pdfconference objec