21 research outputs found

    A Simple Data Relay Process and Turbo Code Application to Wireless Sensor Networks

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    In this study, we focus on relay process of intermediate node of wireless sensor networks. In conventional wireless sensor networks, the intermediate node performs the regenerative repeating process such that error correction, detection and reencoding are processed. This is reliable, but it requires a lot of processing effort and may take much energy. To reduce a burden of relay process, we propose to omit error decoding and/or reencoding process at the intermediate nodes. Further, we propose a method that realizes soft-decision decoding for hard-detected signals. With this method, we can employ Turbo code to wireless sensor networks. As results, we show that though omitting the decoding and re-encoding process at the intermediate node may not affect much to the performance.journal articl

    Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma

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    Background: Diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), is the most frequent type of lymphoid neoplasm. Methods: We investigated the relationships between clinical factors of DLBCL-NOS and MYC immunohistochemistry (IHC) staining. Results: A total of 110 patients diagnosed with DLBCL-NOS from 2012 to 2020 at Tottori University Hospital and treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy were included. IHC staining of MYC in formalin-fixed, paraffin-embedded tumor specimens was performed, and ROC-curve analysis revealed the cut-off value of the MYC positive rate as 55%. The 2-year overall survival (OS) rates of the MYC-negative and -positive groups were 84.7% vs 57.7% (P = 0.0091), and the progression-free survival rates were 77.8% vs 54.7% (P = 0.016), respectively. Multivariate analysis for OS showed prognostic significance of MYC positivity [hazards ratio (HR): 2.496; P = 0.032], and serum levels of soluble interleukin-2 receptor (sIL-2R) > 2000 U/mL (HR: 3.950; P = 0.0019), as well as age > 75 (HR: 2.356; P = 0.068). The original scoring system was developed based on these findings. By assigning one point to each item, age (> 75), MYC positivity, and sIL-2R level (> 2000), all patients were classified into three risk categories: group 1 (0 points), group 2 (1 point), and group 3 (2–3 points). The 2-year survival rates were 100%, 83.0%, and 47.1% for the groups 1, 2, and 3, respectively (P < 0.0001). Conclusion: We suggest that a prognostic scoring system using MYC expression and soluble interleukin receptor -2 level is useful for the prediction of prognosis, contributing to further stratification in DLBCL-NOS.journal articl

    Measurement of the B0-B0 mixing rate with B0(B0)→D*∓π± partial reconstruction

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    レンゾク メディア ショリ ニ オケル CPU ノ ヨヤク カンリ ホウシキ ニ カンスル ケンキュウ

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    奈良先端科学技術大学院大学修士(工学)master thesi

    Ferroelectric Properties of BaTi_<0.91>(Hf_<0.5>Zr<0.5>)_<0.09>O_3 Thin Films Fabricated by Pulsed Laser Deposition

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    BaTi_(Hf_Zr)_O_3 thin films were formed on Pt(111)/Ti/SiO_2/Si(100)substrates by pulsed laser deposition using fourth-harmonic-generated light(λ=266nm)of a Nd^ :YAG laser beam. Crystallinity and stoichiometry of the thin films were determined by X-ray diffraction X-ray fluorescence analysis and electron probe microanalysis. Their ferroelectric properties were investigated from electrical measurements. The leakage current density increased from 10^ to 10^ A・cm^with increasing electric field up to 200kV. cm^. The dielectric constant, remanent polarization and coercive field of tghe BaTi_(Hf_Zr)_O_ thin films were estimated to be 120 at 1 kHz, 8.7 μC・cm^ and 127kV・cmrespectively.application/pdfjournal articl

    Synthesis and Characterization of 3-Arylquinazolinone and 3-Arylquinazolinethione Derivatives as Selective Estrogen Receptor Beta Modulators

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    On the basis of the stucture of genistein, a new series of 3-arylquinazolines was prepared and tested for their estrogen receptor (ER) α and β affinities. 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinone (1aa) acts as an agonist on both ER subtypes. It has 62-fold higher binding affinity [IC50(ERβ) = 179 nM] and 38-fold higher functional potency in a transcription assay [EC50(ERβ) = 76 nM] with ERβ than with ERα, thus improving upon the selectivity of genistein. All of the analogues showed preferential binding affinity for ERβ. Many are also more potent in activating transcription by ERβ than by ERα. Transformation of the CO functionality at position 4 into a CS group provided 5,7-dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinethione (1ba), which acts as an agonist on both ER subtypes but has 56-fold higher binding affinity for ERβ over ERα [IC50(ERβ) = 47 nM] and 215-fold higher potency in the transcription assay [EC50(ERβ) = 13 nM]. These ERβ-selective compounds may represent valuable tools in understanding the differences in structure and biological function of ERβ and ERα

    Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders

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    The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in in vitro biochemical and cell-based assays, and it selectively reduces serotonin levels in the murine intestine after oral administration without affecting levels in the brain. These TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome
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