強磁性希土類化合物Ce2Ni5C3における圧力誘起磁気相転移の研究

学位記号番号 : 博理工甲第774号博士の専攻分野の名称 : 博士(理学) 学位授与年月日 : 平成22年3月24日textapplication/pdfthesi

About approach of starry sky sightseeing in the Katsuyama, Kitadani-Cho Ohara Village

Ohara village is a mountain village of the special heavy snowfall area in the valleys of the Ishikawa prefectural border. There are only two residents in this village, so it is thought that there will be no settlement in the near future. In this paper about approach of starry sky sightseeing in the Katsuyama, Kitadani-Cho Ohara Village. A total of eight meetings were held for sightseeing tours, with the main theme being starry sky. The questionnaire favorable opinion a lot, was a very meaningful tour. But there are a few bad points, this is towards the 2019, and there is a need to improve. Also 2019 is scheduled to conduct a similar tour.departmental bulletin pape

90年代のブルターニュ再生 - "グローカル" なイメージ戦略としてのマーケティング地域主義と言語 -

2002-11-15departmental bulletin pape

ミサワ カツエ ノ フウドガク オ ベース ニ キョウイク サンギョウ カラ チイキズクリ ニ カンスル イチコウサツ

地理学者で教育者であった三澤勝衛(1885-1937)が主張した教育理念や「風土産業」を基底に、日本の教育と飯田市の産業からその姿を明らかにし、過疎高齢化する中山間地域のあり方を考察した。1では、三澤勝衛の新地理教育論から教育のあり方を探る。2では、長野県飯田市の産業の歴史から「風土産業」を読み解く。3では、風土を最大限活かした飯田型ツーリズムから風土産業を解題する。4では、第1章から3章から論点を整理し、地域再生のあり方を提案する。特集【地域社会とそのリノベーション】application/pdfdepartmental bulletin pape

"Ruijumyogishou"Yonshu-shoutentsuki-wakun-shusei

pdfboo

Study on Last-Mile Delivery Efficiency in Underpopulated Areas

：「2024 年問題」によって、トラックドライバーの人手不足はさらに深刻化している。また、日本の市町村の半数を占める過疎地域では、配送効率の低さが課題となっている。過疎地域の課題と人手不足問題に対して、「補完可能性」を観点とするドローン物流に着目した。過疎地域でのラストワンマイルは、その地域特性のため配送の効率化が難しい。本研究では、過疎地域でのラストワンマイル配送の効率化のため、ドローン物流を活用し た補完可能性について明らかにする。The “2024 problem” has further exacerbated the labor shortage of truck drivers. Low delivery efficiency is also a problem in sparsely populated areas, which account for half of Japan’s municipalities. This paper focuses on drone logistics from the viewpoint of “complementability” for problems in sparsely populated areas and labor shortages. It is difficult to improve the efficiency of delivery for the last mile in sparsely populated areas because of the regional characteristics. Therefore, this study clarifies the complementarity of using drone logistics to improve the efficiency of last-mile delivery in sparsely populated areas.departmental bulletin pape

農村地域におけるグリーンツーリズム・ネットワークの構築手法

textその他/Othersothe

Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1 Axis in a Non-alcoholic Steatohepatitis Mouse Model

[Background] Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is a chronic liver disease related to metabolic syndrome that can progress to liver cirrhosis. The involvement of the endoplasmic reticulum (ER) stress response in NAFLD progression and the roles played by activating factor 3 (ATF3) and the downstream nuclear protein 1 (NUPR1) are poorly understood. The aim of this study was to determine the gene expression profiles around the ATF3/NUPR1 axis in relation to the development of NAFLD using novel mouse models. [Methods] Fatty liver Shionogi (FLS) mice (n = 12) as a NAFLD model and FLS-ob/ob mice (n = 28) as a NASH model were fed a standard diet. The FLS mice were sacrificed at 24 weeks of age as a control, whereas the FLS-ob/ob mice were sacrificed at 24, 36, and 48 weeks of age. Hepatic steatosis, inflammation, and fibrosis were evaluated by biochemical, histological, and gene expression analyses. The expression levels of the ER-stress related genes Jun proto-oncogene (C-jun), Atf3, Nupr1, and C/EBP homologous protein (Chop) were measured in liver tissue. Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. [Results] Control mice demonstrated hepatic steatosis alone without apparent fibrosis. On the other hand, FLS-ob/ob mice showed severe steatohepatitis at both 24 and 36 weeks of age and severe fibrosis at both 36 and 48 weeks of age. The expression levels of Atf3, Nupr-1, and C-jun significantly increased from 24 to 48 weeks of age in FLS-ob/ob mice compared with control mice. The expression level of Chop was already high in FLS mice and maintained similar levels in FLS-ob/ob mice; the expression level was consistent with the percentage of TUNEL-positive cells. [Conclusion] The ATF3/NUPR1 axis plays a pivotal role in NASH progression in association with C-jun and Chop and appears to induce apoptosis from early steatosis in the NASH model mice.journal articl

Study of time-dependent CP-violating asymmetries in b→sq̅q decays

journal articl

Effect of the BRCA1 452–1079 amino acids fragment on WRN helicase and exonuclease activities

<p><b>Copyright information:</b></p><p>Taken from "Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links"</p><p>Nucleic Acids Research 2006;34(9):2751-2760.</p><p>Published online 19 May 2006</p><p>PMCID:PMC1464112.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> () WRN helicase activity was measured as described in using a 22 bp forked duplex substrate. () WRN exonuclease activity was measured on a 34 bp forked duplex substrate. Purified WRN was pre-incubated with BRCA1 452–1079 amino acids at the indicated concentrations in 10 µl assay buffer. The mean percent strand displacement or digestion ( = 2) on the substrate is shown