Application of chiral 1,3-amino alcohols to asymmetric alkylation and arylation and the substituent eff ect on chirality control

学位記号番号 : 博理工甲第776号博士の専攻分野の名称 : 博士(工学) 学位授与年月日 : 平成22年3月24日textapplication/pdfthesi

Report about Starry Sky Tourism in Seto Village in the Minamiechizen

This report settles a method to push forward starlit sky sightseeing. The target area is "village Seto" of Minami-Echizen-cho, Nanjo-gun in the central part of Fukui, and this village is a small area among the forest, and a population decline advances. We plan the tourism which assumed these tourist attractions in "blue snow" being characteristic when "a star looks beautiful" in this village. This report shows various conditions for the establishment of the starlit sky sightseeing and introduces an action from 2017 through 2018.departmental bulletin pape

視覚詩を読むこと - Steve McCaffery の Carnival

2002-11-15departmental bulletin pape

撮影方法および画像内の位置が歯槽骨密度計測に与える影響

朝日大学博士（歯学）2023年度doctoral thesi

生活環境，地域の多様性に配慮した公営住宅のリノベーション手法

textその他/Othersothe

Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1 Axis in a Non-alcoholic Steatohepatitis Mouse Model

[Background] Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is a chronic liver disease related to metabolic syndrome that can progress to liver cirrhosis. The involvement of the endoplasmic reticulum (ER) stress response in NAFLD progression and the roles played by activating factor 3 (ATF3) and the downstream nuclear protein 1 (NUPR1) are poorly understood. The aim of this study was to determine the gene expression profiles around the ATF3/NUPR1 axis in relation to the development of NAFLD using novel mouse models. [Methods] Fatty liver Shionogi (FLS) mice (n = 12) as a NAFLD model and FLS-ob/ob mice (n = 28) as a NASH model were fed a standard diet. The FLS mice were sacrificed at 24 weeks of age as a control, whereas the FLS-ob/ob mice were sacrificed at 24, 36, and 48 weeks of age. Hepatic steatosis, inflammation, and fibrosis were evaluated by biochemical, histological, and gene expression analyses. The expression levels of the ER-stress related genes Jun proto-oncogene (C-jun), Atf3, Nupr1, and C/EBP homologous protein (Chop) were measured in liver tissue. Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. [Results] Control mice demonstrated hepatic steatosis alone without apparent fibrosis. On the other hand, FLS-ob/ob mice showed severe steatohepatitis at both 24 and 36 weeks of age and severe fibrosis at both 36 and 48 weeks of age. The expression levels of Atf3, Nupr-1, and C-jun significantly increased from 24 to 48 weeks of age in FLS-ob/ob mice compared with control mice. The expression level of Chop was already high in FLS mice and maintained similar levels in FLS-ob/ob mice; the expression level was consistent with the percentage of TUNEL-positive cells. [Conclusion] The ATF3/NUPR1 axis plays a pivotal role in NASH progression in association with C-jun and Chop and appears to induce apoptosis from early steatosis in the NASH model mice.journal articl

A case of spaced arch with retarded eruption of upper first molars and congenital missing of lower first molars

空歯列の20 歳3 か月の女性に対して、パノラマエックス線写真、口腔模型および頭部エックス線規格写真を用いて大臼歯と顎顔面形態の特徴を検討した。本症例の大臼歯について、萌出時期、萌出位置・方向、歯冠・歯根の形成状態および歯冠形態から、上顎第一大臼歯は萌出遅延、下顎第一大臼歯は先天欠如していると診断した。また、顎顔面形態については、骨格形態の計測値は標準範囲内で、骨格性Ⅰ級，アベレージアングル症例であった。歯性には、下顎第二大臼歯の歯冠幅径は第一大臼歯歯冠幅径の標準範囲より1標準偏差を超えて小さく、上下顎歯列ともに空歯列を認めた。The characteristics of molar and maxillofacial morphology were examined using panoramic radiographs, dental models, and cephalometric radiographs of a 20-year-old 3-month-old female with a spaced arch. Based on the time of eruption, position and direction of eruption, tooth crown and root formation, and crown morphology, the upper first molar was diagnosed as retarded eruption and the lower first molar was diagnosed as congenitally missing. The patient’s craniofacial morphology showed skeletal Class I and average angle case. The dentition was characterized by a small crown width of the lower second molar and a spaced arch.departmental bulletin pape

Study of time-dependent CP-violating asymmetries in b→sq̅q decays

journal articl

Engineering Antibodies Targeting p16 MHC-Peptide Complexes

Senescent cells undergo a permanent cell cycle arrest and drive a host of age-related pathologies. Recent transgenic mouse models indicate that removing cells expressing the senescence marker p16Ink4a (p16) can increase median lifespan and delay the onset of many aging phenotypes. However, identifying and eliminating native human cells expressing p16 has remained a challenge. We hypothesize that senescent cells display peptides derived from p16 in major histocompatibility complex (MHC)-peptide complexes on the cell surface that could serve as targetable antigens for antibody-based biologics. Using Fab-phage display technology, we generated antibodies that bind to a p16 MHC-peptide complex from the human leukocyte antigen (HLA) allele HLA-B*35:01. When converted to single-chain Fab chimeric antigen receptor (CAR) constructs, these antibodies can recognize naturally presented p16 MHC-peptide complexes on the surface of cells and activate Jurkat cells. Furthermore, we developed antibodies against predicted p16 MHC-peptide complexes for HLA-A*02:01 that specifically recognize their respective antigen on the surface of cells. These tools establish a platform to survey the surface of senescent cells and provide a potential novel senolytic strategy