Asymptotic Analysis of Stress Fields around Elastic/Elastic-Plastic Interface Edge of Dissimilar Materials Joints

学位記号番号 : 博理工甲第811号博士の専攻分野の名称 : 博士(学術) 学位授与年月日 : 平成22年9月17日textapplication/pdfthesi

新聞記事データベースの解析による 明治期以降の多摩川における生態系サービスの変遷

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Progress Report of Remote Island Activation Project through Rainwater Utilization in Akashima, Goto City, Nagasaki Prefecture

Akashima, Goto City, Nagasaki Prefecture is a small secondary island with an area of 0.52m2. There is no water supply on this island, and there are no common freshwater sources, such as river water and groundwater, anymore. Therefore, the islanders live using rainwater stored in a rainwater storage tank for their water usage in daily life . A survey on the use of rainwater in Akashima in 2016 found that there were water shortages and water quality problems. In addition, it was found that the number of islanders on this island is about 15; therefore, there is also the problem of unmanned islanding. Based on these findings, a small-scale village water supply system, which uses rainwater as its source, was installed on the island in 2017. Additionally, in seeking to prevent unmanned islanding, we have devised and implemented an environmental education program for water, “Rainwater Life Experience," as well as initiated the promotion of Akashima through the Internet."departmental bulletin pape

Pharmacokinetic Drug Interaction Between Rosuvastatin and Tanjin in Healthy Volunteers and Rats

[Background] Tanjin is an herbal medicine made from the root of salvia miltiorrhiza. It is predominantly given to arteriosclerotic patients as a supplement to ameliorate the clinical symptoms of cardiovascular diseases. In China, tanjin is used frequently in combination treatment for hypercholesterolemia. Thus, there is a high probability of combination of tanjin and statins in these arteriosclerotic patients. This study investigated the interaction between tanjin and rosuvastatin. [Methods] We performed a randomized single-blind, two-period crossover clinical trial on six healthy male volunteers. Volunteers were administered rosuvastatin with placebo or a tanjin-containing drug randomly. The blood samples were collected before drug administration, and at 0.5, 1, 1.5, 2, 4, 8, and 12 hours after administration. Lymphocytes were isolated from blood samples before and 12 hours after drug administration to measure mRNA. As an animal experiment, an in situ intestinal injection with portal vein sampling model was used to examine the interaction between tanjin and rosuvastatin during the absorption phase. Rosuvastatin or rosuvastatin combined with tanjin solution was injected into the intestine. After injection, blood from the portal vein was collected and the concentration of rosuvastatin was measured by LC/MS/MS analysis. A portion of the intestine and liver from the rats was collected and stored at -80°C for mRNA measurement. [Results] In the clinical trial, co-administration of tanjin decreased the maximum plasma concentration (Cmax) of rosuvastatin by 26.85% compared with rosuvastatin alone, and also decreased the area under the plasma concentration-time curve of rosuvastatin from 0 to 12 h (AUC0?12) by 19.43%. The relative expression of BCRP and OATP mRNA in human lymphocytes was increased by co-administration of tanjin. In the animal experiment, co-administration of tanjin extract reduced the concentration of rosuvastatin to 84.4, 64.4, and 50.0% at 15, 30, and 45 minutes, respectively. The tanjin-containing drug had a similar effect to tanjin extract. Furthermore, tanjin significantly reduced the absorption of rosuvastatin and the inhibitory effects lasted for at least 24 hours. Tanjin increased the relative expression of BCRP mRNA in the intestine, but it did not change the expression of OATP. Moreover, the concentration of rosuvastatin in the portal vein and systemic blood was reduced. In the liver, tanjin increased both BCRP and OATP mRNA expression, which was consistent with the results from human lymphocytes. [Conclusion] The clinical trial and animal experiment revealed that tanjin can significantly reduce the absorption of rosuvastatin. This interaction occurred, at least, at the absorption phase in the small intestine due to the enhanced efflux transport. Thus, as tanjin and rosuvastatin were found to interact, their combination needs to be paid attention to.journal articl

Study of time-dependent CP-violating asymmetries in b→sq̅q decays

journal articl

One's Way 構文に起きる動詞とOne's Way構文の意識的使用について (1) - Cobuild Direct の言語資料から言えること -

1999-10-25departmental bulletin pape

Supplemental material for Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension

Supplemental material for Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension by Shin Watanabe, Kiyotake Ishikawa, Maria Plataki, Olympia Bikou, Erik Kohlbrenner, Jaume Aguero, Lahouaria Hadri, Iratxe Zarragoikoetxea, Kenneth Fish, Jane A. Leopold and Roger J. Hajjar in Pulmonary Circulation</p

The harmonization process to set up and maintain an operational biological and physical retrospective dosimetry network: QA QM applied to the RENEB network

Purpose: The European Network of Biological and Physical Retrospective Dosimetry ‘RENEB’ has contributed to European radiation emergency preparedness. To give homogeneous dose estimation results, RENEB partners must harmonize their processes. Materials and methods: A first inter-comparison focused on biological and physical dosimetry was used to detect the outliers in terms of dose estimation. Subsequently, trainings were organized to improve both tools dose estimation. A second inter-comparison was performed to validate training efficiency. Simultaneously, based on ISO standards, a QA&QM manual on all dosimetry assays was produced which states a common basis and harmonized procedures for each assay. The evaluation of the agreement of RENEB partners to follow the QA&QM manual was performed through a questionnaire. The integration of new members into the network was carried out in the same way, whatever the assays. Results: The training courses on biological and physical dosimetry were judged to be successful because most of the RENEB members’ dose estimates improved in the second inter-comparison. The QA&QM manual describes the consensus for the minimum requirements and the performance criteria for both dosimetry assays. The questionnaire revealed that the whole network capacity currently can manage between 15 and 3800 samples once. Conclusion: The methodology used to harmonize all dosimetry practice within the network RENEB was highly successful. The network is operational to manage a mass casualty radiation accident for immediate dose assessment