甲状腺細胞傷害が誘導する自然免疫反応活性化機構の解明

学位記号番号 : 博理工甲第820号博士の専攻分野の名称 : 博士(理学) 学位授与年月日 : 平成23年3月23日textapplication/pdfthesi

言語による心的辞書構造の違い

2002-12-15departmental bulletin pape

熱誘導タイポドントシステムを用いた上顎大臼歯遠心移動の三次元的評価

朝日大学博士（歯学）2023年度doctoral thesi

ラーニング・コモンズにおける学習支援に関する一考察

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Record of living utilizing regional resources(About Miyama's Charcoal grill kiln "Ashizumigama" efforts)

In Fukui prefecture there are various traditional crafts and industrial technology cultivated through the period of high growth. However, with the lack of successors now, people, techniques and things that inherit that technology are being lost. The author continued interviewing Mr. Keibun Fujii, who is the former representative of the NPO “General incorporated association Kichizukuri Fukui" and is the present representative of "General incorporated association of Marginal settlement A43". He is making charcoal kilns at a marginal settlement. The author recorded his activities at the settlement on the video. I will present the recording as a recorded image and an activity report on those who are responsible for conservation of regional resources.departmental bulletin pape

Effect of Cetuximab and EGFR Small Interfering RNA Combination Treatment in NSCLC Cell Lines with Wild Type EGFR and Use of KRAS as a Possible Biomarker for Treatment Responsiveness

[Background] The epidermal growth factor receptor (EGFR) is a therapeutic target for patients with non-small cell lung cancer (NSCLC). Cetuximab is an anti-EGFR monoclonal antibody that inhibits EGFR signaling and proliferation of colorectal cancer and head and neck cancers. Since only few NSCLC patients benefit from cetuximab therapy, we evaluated a novel combination treatment using cetuximab and EGFR small interfering RNA (siRNA) to strongly suppress EGFR signaling and searched for a biomarker in NSCLC cell lines harboring wild-type EGFR. [Methods] Alterations in EGFR and its downstream genes in five NSCLC cell lines (A549, Lu99, 86-2, Sq19 and Ma10) were assessed through sequencing. The protein expression levels of these molecules were assessed through western blotting. The effect of combination treatment was determined through cell proliferation assay, caspase-3/7 assay, invasion assay, and migration assay. [Results] All cell lines were harboring wild-type EGFR, whereas KRAS, PTEN, TP53 and TP53 were mutated in A549 and Lu99; Lu99 and Sq19; Lu99, 86-2, Sq19 and Ma10; and A549, 86-2, and Sq19 cell lines, respectively. PTEN was not expressed in Sq19, and LKB1 was not expressed in both A549 and Sq19. TP53 was not expressed in both A549 and Lu99. The combination of cetuximab and EGFR siRNA significantly suppressed cell proliferation in 86-2, Sq19 and Ma10, which express wild-type KRAS. It induced apoptosis in A549, 86-2 and Ma10 cells, which express wild type PTEN. The combination treatment had no effect either on cell invasion nor migration in all cell lines. [Conclusion] EGFR targeted therapy using the combination of cetuximab and EGFR siRNA is effective in NSCLC cell lines harboring wild-type EGFR. Wild-type KRAS may act as a potential biomarker for response to combination treatment by the induction of apoptosis in cells with wild-type PTEN.journal articl

Study of time-dependent CP-violating asymmetries in b→sq̅q decays

journal articl

Suppression of Cavitation Instabilities in an Inducer by J-Groove

application/pdfThe suppression of cavitation instabilities was attempted through the control of tip leakage vortex cavitation. The control was made by using shallow grooves, called J-groove, on the casing wall. With J-groove, the onset regions of the rotating cavitation and the asymmetric cavitation could be diminished. However, a cavitation surge appeared at higher cavitation numbers. From the observation of cavitation, it was found that the cavitation surge occurred when the tip leakage vortex cavitation started to interact with the leading edge of the next blade. This type of cavitation surge could be avoided by extending the leading edge of J-groove upstream. However, in this case, another type of cavitation surge occurred at much lower cavitation numbers, which was caused by the cavitation between the blade surface and the tip leakage vortex cavitation. These results highlight the importance of the tip leakage vortex cavitation for cavitation instabilities.conference pape

makkusu weba ni okeru rekishi kagaku no tenkai

制度:新 ; 文部省報告番号:甲1325号 ; 学位の種類:博士(文学) ; 授与年月日:1999/2/9 ; 早大学位記番号:新2758本文PDFは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルをPDFに変換したものである

International Multicenter Validation Study of the SAGIT® Instrument in Acromegaly: Infographic

The SAGIT® instrument (SAGIT) has been developed to help practicing endocrinologists to better characterize disease activity, providing a precise classification of acromegaly severity. This infographic documents the utility of SAGIT, the developmental journey and the results from the most recent validation study