常燕生について : 1930年代半ばの思想を中心に

2003-03departmental bulletin pape

Distinguishing Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion from Prolonged Febrile Seizures by Acute Phase EEG Spectrum Analysis

journal articl

Improved measurement of mixing-induced CP violation in the neutral B meson system

journal articl

キリュウ ノ シミュレーション ト リュウシ モデル オ モチイタ カサイ ノ ギジテキ ヒョウゲン

奈良先端科学技術大学院大学修士(工学)master thesi

Kinetic stabilization of the o-quinoidal 3,4-benzotropone system

Kinetic stabilization of the o-quinoidal 3,4-benzotropone system was investigated. The parent 3,4-benzotropone 1 undergoes rapid [π8 + π10] dimerization in fluid solution even at -78 °C while triptycene-fused derivative 5 having a tert-butyl group at the C(6) position of the tropone moiety was found to be stable indefinitely under similar conditions. The relative importance of the triptycene moiety and the tert-butyl group in 5 for the kinetic stabilization was evaluated

Felling by a Five-Legged Walking-Machine

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

Rejection of the E42 Pig Pancreas in Different Immunologically Mutant Mice

<p>Grafts of E42 pig pancreas were transplanted under the kidney capsule of NOD-SCID (A), C57BL/6 (B), XID (C), and nude (D) mice and harvested 17 d after transplant. Note the extensive fibrosis and infiltration indicating rejection in the C57BL/6 and XID mice, while pancreatic components are seen in the NOD-SCID and nude mice. Each group included five mice.</p

Pig Insulin Secretion and Histological Appearance of Long-Standing Embryonic Pancreatic Grafts

<div><p>(A) Pig insulin levels following transplantation of E28, E42, E56, and E80 pig pancreas tissues under the kidney capsule of NOD-SCID mice. The data are based on average ± standard deviation pig insulin level measured in seven independent experiments, each of which includes comparison among pig pancreatic precursors of two to three different gestational ages (*, <i>p</i> < 0.05; ***, <i>p</i> < 0.005; comparing E42 or E56 with E28 pig insulin levels). </p> <p>(B) E42 pig pancreatic grafts 5 mo after transplantation under the kidney capsule of NOD-SCID mice. Macroscopic appearance reveals a large viable graft that covers the kidney and contains abundant blood vessels (panel A); the graft is marked by an arrow. Histological analysis of the grafts demonstrates mainly dense islets of different sizes (panel B) (Hematoxylin and Eosin staining; islets marked by arrows). The ability of these islets to produce hormones is evident by positive staining for insulin (panel C), glucagon (panel D), and pancreatic polypeptide (panel E). Close proximity between islets and ducts is occasionally seen (panel C, magnified inset). The epithelial cells are widely stained for cytokeratin 20 (panel F).</p></div

Insulin Secretion following Transplantation of E42 and E56 Pig Embryonic Pancreatic Tissues in the “Humanized” SCID Mouse Model

<p>Pig insulin levels were measured 4 wk after transplantation of E42 and E56 pig pancreas into NOD-SCID mice in the absence (black bars) and presence (grey bars) of 80 × 10⁶ adoptively transferred hu-PBMCs infused into the grafted mice 1–3 d after transplant. Four experiments were carried out, each comparing pig insulin levels secreted by the grafts from two gestational time points. The bars represent average ± standard deviation pig insulin levels measured in all experiments. The number of grafted NOD-SCID mice without and with hu-PBMCs, respectively, was as follows: 19 and 17 for E42, and 15 and 14 for E56. </p

Pig Insulin Secretion and Histological Findings of E42 Pig Embryonic Pancreas Transplanted in NOD-SCID and Immunocompetent Mice Treated with Costimulatory Blockade

<div><p>(A) Pig insulin secretion by E42 pig pancreatic grafts implanted under the kidney capsule of NOD-SCID mice (black bars) or C57BL/6 mice treated every 2 wk with CTLA4-Ig and anti-CD40L (grey bars). No pig insulin could be detected in negative control transplanted C57BL/6 mice in the absence of immunosuppression, therefore these results are not shown. Each group included 13 mice.</p> <p>(B) Histological findings 3 mo following E42 pig pancreas transplantation under the kidney capsule of NOD-SCID mice (panel A), immunocompetent C57BL/6 mice (panel B), and C57BL/6 mice treated biweekly with CTAL4-Ig and anti-CD40L (panel C). Note the fierce rejection in C57BL/6 mice evident by implant destruction and fibrosis in (panel B), while intact graft development is demonstrated in C57BL/6 mice treated with CTLA4-Ig and anti-CD40L (panel C) revealing positive staining for insulin (panel D). A small number of mouse CD3 cells (panel E) and macrophages (panel F, stained by F4/80) infiltrated the graft parenchyma (marked by arrowheads) without causing apparent damage to the pancreatic structures.</p></div