Grouping English Communication Classes by Level : Reforming Systems Post-COVID Pandemic Restrictions

departmental bulletin pape

Cancer Nursing Research on the learning needs of hospital nurses FY2010

当院が都道府県がん診療連携拠点病院に指定されてから、がん患者の受診が多くなり現在では約4割ががん患者である。がん医療に携わる看護職の人材育成のために勉強会や事例検討会を行ってきた。しかし年々参加人数が減少し、プログラム自体の見直しが必要であると思われ、看護師の学習ニーズを明らかにしたいと考えた。そこでアンケート調査を行ったところ、がん看護への関心が高いことが明らかになり、対象者を絞った学習計画を立てることが必要と示唆された。Article信州大学医学部附属病院看護研究集録 39(1): 5-18(2011)departmental bulletin pape

Observation of b→dγ and Determination of |Vtd/Vts|

journal articl

大学における知的資源の共有化モデル : Webを中心に(<特集>INFOSTAシンポジウム'98)

rights: 社団法人情報科学技術協会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: isVersionOf:http://ci.nii.ac.jp/naid/110002827979textapplication/pdfjournal articl

An Essay on Some Simple Blowing Machines used in the Mines of this Country with Improvement Suggested

工部大学校種別:卒業論文thesi

アメリカ福祉国家の再編（一） リスクの「私化」と1990年代の分岐点

2007-12-25departmental bulletin pape

HMG Domain Containing SSRP1 Is Required for DNA Demethylation and Genomic Imprinting in Arabidopsis

In Arabidopsis, DEMETER (DME) DNA demethylase contributes to reprogramming of the epigenetic state of the genome in the central cell. However, other aspects of the active DNA demethylation processes remain elusive. Here we show that Arabidopsis SSRP1, known as an HMG domain-containing component of FACT histone chaperone, is required for DNA demethylation and for activation and repression of many parentally imprinted genes in the central cell. Although loss of DNA methylation releases silencing of the imprinted FWA-GFP, double ssrp1-3;met1-3 mutants surprisingly showed limited activation of maternal FWA-GFP in the central cell, and only became fully active after several nuclear divisions in the endosperm. This behavior was in contrast to the dme-1;met1 double mutant in which hypomethylation of FWA-GFP by met1 suppressed the DNA demethylation defect of dme-1. We propose that active DNA demethylation by DME requires SSRP1 function through a distinctly different process from direct DNA methylation control.journal articl

IL-7 up-regulates TNF-α production in cell culture media.

<p>PBMC and monocytes plus T or B cells were cultured in absence or presence of IL-7. Supernatants were collected at days 5 and 10 to dose TNF-α. PBMCs showed the same TNF-α basal level, which increased at 2,5 ng/ml of IL-7 and reached the maximum value at 15 ng/ml, <b>(A)</b>. Monocytes plus T cells (M+T) <b>(B)</b> and monocytes plus B cells (M+B) <b>(C)</b> had a TNF-α basal level higher at day 10 than at day 5, but both supernatants showed the peak value at 2,5 ng/ml of IL-7, and remained roughly costant at 15 ng/ml. The data were means±SE of 25 supernatants collected at day 5 and 10 for both patients and healthy controls.</p

Quantitative analysis of IL-7 expression in T and B cells.

<p>IL-7 expression was evaluated by RQ-PCR using 2^−ΔΔCt method. B cells derived from cancer patients expressed significantly higher levels of IL-7 compared to T cells. Both T and B cells from healthy controls expressed less IL-7 than patients. The control bar represents the negative control: IL-7 expression in H522 cell line. Data are means±SE of nine independent experiments.</p

Table_1_Effects of Sweet Cherry Polyphenols on Enhanced Osteoclastogenesis Associated With Childhood Obesity.doc

Childhood obesity is associated with the development of severe comorbidities, such as diabetes, cardiovascular diseases, and increased risk of osteopenia/osteoporosis and fractures. The status of low-grade inflammation associated to obesity can be reversed through an enhanced physical activity and by consumption of food enrich of anti-inflammatory compounds, such as omega-3 fatty acids and polyphenols. The aim of this study was to deepen the mechanisms of bone impairment in obese children and adolescents through the evaluation of the osteoclastogenic potential of peripheral blood mononuclear cells (PBMCs), and the assessment of the serum levels of RANKL and osteoprotegerin (OPG). Furthermore, we aimed to evaluate the in vitro effects of polyphenol cherry extracts on osteoclastogenesis, as possible dietary treatment to improve bone health in obese subjects. High RANKL levels were measured in obese with respect to controls (115.48 ± 35.20 pg/ml vs. 87.18 ± 17.82 pg/ml; p + osteoclasts (OCs) were observed in the un-stimulated cultures of obese subjects compared to the controls. Interestingly, obese subjects displayed a higher percentage of CD14+/CD16+ than controls. Furthermore, in the mRNA extracts of obese subjects we detected a 2.5- and 2-fold increase of TNFα and RANKL transcripts compared to controls, respectively. Each extract of sweet cherries determined a dose-dependent reduction in the formation of multinucleated TRAP+ OCs. Consistently, 24 h treatment of obese PBMCs with sweet cherry extracts from the three cultivars resulted in a significant reduction of the expression of TNFα. In conclusion, the bone impairment in obese children and adolescents is sustained by a spontaneous osteoclastogenesis that can be inhibited in vitro by the polyphenol content of sweet cherries. Thus, our study opens future perspectives for the use of sweet cherry extracts, appropriately formulated as nutraceutical food, as preventive in healthy children and therapeutic in obese ones.</p