頭頸部がん患者の放射線療法・化学療法時の健康状態改善のための食事指導の具現化と課題 : 患者の食生活の質を高める看護師の役割

University of Yamanashi (山梨大学)博士(看護学)医工博甲第361号thesi

Observation of b→dγ and Determination of |Vtd/Vts|

journal articl

煉炭製造計画

東京帝国大学工科大学種別:卒業論文thesi

電力平準化装置の導入による分散型電源の連系可能容量算定法に関する研究

application/pdf三重大学大学院工学研究科博士前期課程電気電子工学専攻53thesi

元代浙西地方の官田の貧難佃戸に関する一検討

1972-03-31departmental bulletin pape

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes.

Adult multipotent neural progenitor cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural progenitor cells. Here, we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of bone morphogenetic protein signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.journal articl

民間団体による独居高齢者への支援活動の現状と課題―支援団体へのインタビューから―

application/pdfdepartmental bulletin pape