29 research outputs found
IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes.
Adult multipotent neural progenitor cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural progenitor cells. Here, we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of bone morphogenetic protein signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.journal articl
Survival curve of the elderly people by metabolic syndrome, up to 5 years.
<p>Survival curve of the elderly people by metabolic syndrome, up to 5 years.</p
Unadjusted and adjusted odds ratios (OR) and 95% confidence intervals (CI) of Metabolic Syndrome: Results from logistic regression analyses.
<p>OR = odds ratio; CI = confidence interval.</p><p>*Data on literacy and marital status were missing for 3 participants.</p>#<p>Data on asset index was missing for 24 persons.</p>§<p>Data on Nutritional status was missing for 13 persons.</p>a<p>ORs (95% CIs) were derived from the model that included age, sex, literacy, marital status, asset index, smoking, tobacco leaf and nutritional status.</p
Prevalence of different components of the metabolic syndrome by sex.
<p>*p-value is for comparison between men and women.</p
Characteristics of the study population (n = 456) by status of the metabolic syndrome.
<p>Characteristics of the study population (n = 456) by status of the metabolic syndrome.</p
Five-years survival related to MetS by different components of MetS.
<p>(* p<0.05). RBG = Random Blood Glucose, TG = Triglyceride, BMI = Boby Mass Index.</p
Prevalence of the metabolic syndrome by age and gender.
<p>Prevalence of the metabolic syndrome by age and gender.</p
