Effect of infertility treatment on intrauterine growth: multilevel analysis

University of Yamanashi (山梨大学)博士(医学)医工博4甲第260号thesi

ムスビ ノ ウタ ノ カタリテ ト キキテ : The death of Cuchulain カイシャク ノ タメ ノ オボエガキ

application/pdfdepartmental bulletin pape

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

西山炭坑計画

東京帝国大学工科大学種別:卒業論文thesi

Conversion of a Signal into Forces for Axon Outgrowth through Pak1-Mediated Shootin1 Phosphorylation

Soluble guidance cues can direct cellular protrusion and migration by modulating adhesion and cytoskeletal dynamics. Actin filaments (F-actins) polymerize at the leading edge of motile cells and depolymerize proximally [1 and 2]; this, together with myosin II activity, induces retrograde flow of F-actins [3, 4 and 5]. It has been proposed that the traction forces underlying cellular motility may be regulated by the modulation of coupling efficiency between F-actin flow and the extracellular substrate via “clutch” molecules [6, 7, 8, 9 and 10]. However, how cell signaling controls the coupling efficiency remains unknown. Shootin1 functions as a linker molecule that couples F-actin retrograde flow and the substrate at neuronal growth cones to promote axon outgrowth [11]. Here we show that shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth. We found that a chemoattractant, netrin-1, positively regulates traction forces at axonal growth cones via Pak1-mediated shootin1 phosphorylation. This phosphorylation enhanced the interaction between shootin1 and F-actin retrograde flow, thereby promoting F-actin-substrate coupling, force generation, and concomitant filopodium extension and axon outgrowth. These results suggest that dynamic actin-substrate coupling can transduce chemical signals into mechanical forces to control cellular motility and provide a molecular-level description of how this transduction may occur.journal articl

愛知県における養鶏業の地域的展開

1986-03-31departmental bulletin pape

An analysis scheme for 3D visualization of positron emitting radioisotopes using positron emission mammography system

All data, codes and videos developed in our research work can be downloaded from here

Density and material composition (fraction by weight for each nuclei) used in present model.

Density and material composition (fraction by weight for each nuclei) used in present model.</p

Schematic diagram of water-gel phantom in three dimensions.

Schematic diagram of water-gel phantom in three dimensions.</p

Side view of four regions of interests (ROIs) with their respective height (<i>h</i>), width (<i>w</i>), and depth (<i>d</i>) values.

Side view of four regions of interests (ROIs) with their respective height (h), width (w), and depth (d) values.</p