Toll-like receptor 4 mediates the development of intracranial aneurysm rupture

University of Yamanashi (山梨大学)博士(医学)医工博4甲第278号thesi

Beacon-based sleep-wake monitoring in dogs

The sleep-wake cycle represents a crucial physiological process essential for maintaining homeostasis and promoting individual growth. In dogs, alterations in sleep patterns associated with age and dog's correlation with temperament factors, such as nervousness, have been reported, and there is an increasing demand for precise monitoring of sleep and physical activity in dogs. The present study aims to develop an analysis method for measuring sleep-wake patterns and physical activity in dogs by utilizing an accelerometer and a smartphone. By analyzing time series data collected from the accelerometer attached to the dog's collar, a comprehensive sleep and activity analysis model was constructed. This model classified the activity level into seven classes and effectively highlighted the variations in sleep-activity patterns. Two classes with lower activity levels were considered as sleep, while other five levels were regarded as wake based on the rate of occurrence. This protocol of data acquisition and analysis provides a methodology that enables accurate and extended evaluation of both sleep and physical activity in dogs.journal articl

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

Mutations in the ankyrin repeat domain (ARD) of ?TRPV4 are responsible for several channelopathies, including Charcot?Marie?Tooth disease type 2C and congenital distal and scapuloperoneal spinal muscular atrophy. However, the molecular pathogenesis mediated by these mutations remains elusive, mainly due to limited understanding of the ?TRPV4 ARD function. Here we show that phosphoinositide binding to the ?TRPV4 ARD leads to suppression of the channel activity. Among the phosphoinositides, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) most potently binds to the ?TRPV4 ARD. The crystal structure of the ?TRPV4 ARD in complex with ?inositol-1,4,5-trisphosphate, the head-group of PI(4,5)P2, and the molecular-dynamics simulations revealed the PI(4,5)P2-binding amino-acid residues. The ?TRPV4 channel activities were increased by titration or hydrolysis of membrane PI(4,5)P2. Notably, disease-associated ?TRPV4 mutations that cause a gain-of-function phenotype abolished PI(4,5)P2 binding and PI(4,5)P2 sensitivity. These findings identify ?TRPV4 ARD as a lipid-binding domain in which interactions with PI(4,5)P2 normalize the channel activity in ?TRPV4.journal articl

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

The Smelting of White Pig Iron（白銑製造計画）

東京帝国大学工科大学種別:卒業論文thesi

ハイデッガーと根拠の問題

1992-03departmental bulletin pape

〈論文〉ソーシャルワーカーが多職種と連携して行う自己決定支援の特徴: 特別養護老人ホームの生活相談員へのインタビュー調査から

自己決定を尊重するという原理・原則は、社会福祉領域においては、現在に至るまで中心的原理とされながら様々な矛盾や課題が指摘されており、現在もなおその概念の整理と本質理解の努力が必要とされている。特に、主体的に自己決定できる存在とそうでない存在―例えば認知症などにより判断力の低下した高齢者―についての自己決定支援は、制限・干渉があることが指摘されている。　本研究は、自己決定を尊重する専門職であるソーシャルワーカーが、 多職種と連携して高齢者の自己決定支援を行う際の役割について実証的な分析を行った。認知症などにより判断能力の低下した高齢者を支援するソーシャルワーカーを研究対象とし、半構造化インタビューを行い、その内容について継続的比較分析法を用いて質的・帰納的に分析し、高齢者施設での多職種と連携した自己決定支援についての特徴を導き出し、その関係について図式化した。その結果、 高齢者施設での多職種と連携した自己決定支援の特徴として、“ きく（聴く・訊く・掬く）”、“つなぐ”、“向かう”、“育む（時間を重ねる）”、“みる（見る・観る・視る・看る）”の５つの特徴が導き出された。　導き出した特徴は、 それら自体が相互に関連し合っており、ソーシャルワーカーが高齢者について環境や多職種の視点も含めた総合的な情報を捉えて多職種と連携することによって、より高齢者の意思を尊重した支援ができることが明らかになった。The principle of respect for self-determination has been a central theme in the domain in social welfare work. However,various contradictions and problems to the principle have been pointed out and further research must be conducted toreorganize and understand the essence of the principle. There are people that can be self-determined and those that cannot(e.g. elderly people who have diminished decision-making abilities due to cognitive impairment). Therefore, it has beenpointed out that providing support to develop self-determination has its limitations and restrictions.　An empirical analysis was conducted on the role of social workers in collaboration with other types of workers whenproviding support for self-determination. A semi-structured interview was conducted with social workers that were providingsupport for the elderly with diminished decision-making abilities due to cognitive impairments. The continuouscomparative analysis method was employed for the qualitative and inductive analysis interview contents. Characteristics ofthe coordination between social workers in the process of providing support for self-determination was collected and displayedas a figure. This study identified five characteristics of coordination in elderly care facilities when providing supportfor self-determination: “listen (listen, inquire, and empathize),” “connect,” “move forward,” “develop (spend time),” and“look (look, observe, assess, and take care).”　The characteristics that were identified were reciprocally correlated. Social workers were better able to provide care thatrespected the intentions of the elderly, when they collaborated with different types of workers while making use of informationfrom different work environments.departmental bulletin pape

Control of Human Generating Force by Use of Acoustic Information : Utilization of Onomatopoeic Utterance(<Special Issue>Advanced Technology of Vibration and Sound)

We have performed basic experiments for the purpose of applying onomatopoeia to engineering problems. In these experiments, test subjects were made to perform lifting actions while listening to onomatopoeic utterances. We thereby demonstrated that there is a relationship between the onomatopoeic utterances and the lifting forces exerted by the test subjects. We examined how the lifting forces are related to the envelope of onomatopoeic utterances. Furthermore, we investigated how the lifting force is affected depending on whether or not emotion is expressed when uttering the onomatopoeia.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110004781765/textapplication/pdfjournal articl