Clinical features of early recurrence of type I thoracolumbar intervertebral disk herniation in Miniature Dachshunds

Some reports have been published on clinical features in dogs with early recurrence of type I thoracolumbar intervertebral disk herniation (TL-IVDH), but there is little understanding of the changes involved. This retrospective study describes the clinical features, including radiographic image results at the time of recurrence, of dogs with type I TL-IVDH that had undergone hemilaminectomy but then suffered early recurrence. Our medical records were searched between June 2007 and December 2022. Nine dogs showed deterioration in neurological signs within 4 to 6 weeks after surgery. All nine were Miniature Dachshunds. Radiographic images at initial onset showed calcification at the affected intervertebral disk space in all 9 dogs. Disk herniations at the initial onset were located between T11-12 and L1-2. After the first surgery, neurological function improved in all dogs. Recurrence occurred at the same site as at initial onset in all dogs. No calcification was observed at the affected intervertebral disk space on images at the time of recurrence. The extruded disk materials were surgically removed, and neurological function improved after the second surgery. In conclusion, calcification at the affected disk space at the time of initial onset is indicative of residual nucleus materials not yet fully extruded, and is a risk factor for early recurrence of type I TL-IVDH.journal articl

Spinal epidural empyema concurrent with sequestrum in a cat: a case report

A 5-month-old intact female mixed cat presented with repetitive paraplegia and drainage of pus from the back despite continuous antibiotic medication. Neurologic examination was consistent with below T3-L3 myelopathy. Computed tomography and magnetic resonance imaging revealed a contrast-enhanced mass in the L1-3 spinal canal, and bone fragments in the T13 and L1 spinal canal. Spinal epidural empyema was suspected, and hemilaminectomy was performed for T12-L2 on the right side and T11-12 on the left side. Bone fragments were diagnosed as sequestrum infected with Bacteroides sp. The cat recovered enough to ambulate next day. One month after surgery, there was no deficit in neurological function. This is the first report of spinal epidural empyema concurrent with sequestrum in a cat.journal articl

A feline spinal dermoid cyst treated with surgical intervention

A 5-year-old neutered female mixed cat presented with reduced activity and ataxia of the hind limbs. Computed tomography and magnetic resonance imaging revealed an extradural mass compressing the spinal cord on the dorsal aspects from the 7th to 8th thoracic vertebra. Dorsal laminectomy was performed on the 7-8th thoracic vertebra and the cyst was totally removed, giving full resolution of the clinical signs. The cyst was diagnosed as a dermoid cyst. To our knowledge, this is the first report of feline dermoid cyst compressing the spinal cord that was diagnosed antemortem. The prognosis is favorable when the cyst is completely resected.journal articl

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

Mutations in the ankyrin repeat domain (ARD) of ?TRPV4 are responsible for several channelopathies, including Charcot?Marie?Tooth disease type 2C and congenital distal and scapuloperoneal spinal muscular atrophy. However, the molecular pathogenesis mediated by these mutations remains elusive, mainly due to limited understanding of the ?TRPV4 ARD function. Here we show that phosphoinositide binding to the ?TRPV4 ARD leads to suppression of the channel activity. Among the phosphoinositides, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) most potently binds to the ?TRPV4 ARD. The crystal structure of the ?TRPV4 ARD in complex with ?inositol-1,4,5-trisphosphate, the head-group of PI(4,5)P2, and the molecular-dynamics simulations revealed the PI(4,5)P2-binding amino-acid residues. The ?TRPV4 channel activities were increased by titration or hydrolysis of membrane PI(4,5)P2. Notably, disease-associated ?TRPV4 mutations that cause a gain-of-function phenotype abolished PI(4,5)P2 binding and PI(4,5)P2 sensitivity. These findings identify ?TRPV4 ARD as a lipid-binding domain in which interactions with PI(4,5)P2 normalize the channel activity in ?TRPV4.journal articl

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

Stresses around an Eccentric Hole in an Infinite Strip Subjected to Side Pressure

In this paper, an analytical solution for an infinite strip having an eccentrically located circular hole is given when the strip is subjected to a pair of side pressures. The solution is based on an approach involving Papcovich-Neuber displacement potentials and deduced using the simple forms of Cartesian and cylindrical harmonics. The boundary conditions on both sides of the strip and around the hole are completely satisfied with the aid of the relations between the Cartesian and cylindrical harmonics. The solution is shown in a graph, and the effect of the eccentric hole on the stress distribution is clarified.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110004820920/textapplication/pdfjournal articl

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Supplemental Material, sj-zip-1-jcr-10.1177_0022002719883684 - The Ties That Bind: Ethnicity, Pro-government Militia, and the Dynamics of Violence in Civil War

Supplemental Material, sj-zip-1-jcr-10.1177_0022002719883684 for The Ties That Bind: Ethnicity, Pro-government Militia, and the Dynamics of Violence in Civil War by Luke Abbs, Govinda Clayton and Andrew Thomson in Journal of Conflict Resolution</p

Supplemental Material, sj-pdf-1-jcr-10.1177_0022002719883684 - The Ties That Bind: Ethnicity, Pro-government Militia, and the Dynamics of Violence in Civil War

Supplemental Material, sj-pdf-1-jcr-10.1177_0022002719883684 for The Ties That Bind: Ethnicity, Pro-government Militia, and the Dynamics of Violence in Civil War by Luke Abbs, Govinda Clayton and Andrew Thomson in Journal of Conflict Resolution</p

Basic self-disturbance in the ultra high risk and first episode psychosis populations: findings from the PACE clinic

Basic self-disturbance in the ultra high risk and first episode psychosis populations: findings from the PACE clini