The nature of the heart in Hawthorne's The scarlet letter

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Histologic, immunohistochemical, and in situ hybridization study of myxoid stroma in feline oral squamous cell carcinoma

Oral squamous cell carcinoma (oSCC) is a highly invasive malignant neoplasm in cats. Recently, tumor stroma, known as tumor microenvironments, have been considered to play an essential role in tumor progression. However, their role in feline squamous cell carcinoma (SCC) remains unclear. This study aimed to reveal the cancer microenvironment of feline oSCC and evaluate the pathological mechanisms of progression. We used 19 samples from 17 cats with oSCC, which were examined using light microscopy, immunohistochemistry, and in situ hybridization (RNAscope®). Feline oSCCs had two types of stroma, namely fibrotic and myxoid stromal reaction patterns, which were easily distinguished using hematoxylin-eosin staining. The myxoid stroma was rich in hyaluronic acid, which seems to be produced by neoplastic cells. Furthermore, the presence of myxoid stroma was correlated with histological parameters, including the appearance of cancer-associated fibroblasts and tumor budding. Periostin protein expression was also frequently observed in the stroma of feline oSCC and was significantly more common in the myxoid stromal reaction pattern group than in the fibrotic group. Positive signals for periostin mRNA were detected in stromal cancer-associated fibroblasts. This study indicates that the interaction between neoplastic cells and stromal reaction pattern components, such as hyaluronic acid and periostin, may be involved in tumor malignancy. Therefore, we propose that focus be placed not only on the tumor tissue but also on the characterization of the stroma for analyzing feline oSCC.journal articl

Temperature variation of nonradiative carrier recombination processes in high-quality CuGaSe_2 thin films grown by molecular beam epitaxy

The piezoelectric photoacoustic （PPA） measurements for Cu-rich CuGaSe_2 （CGS）/GaAs（001） epitaxial layer were carried out between liquid helium and room temperatures. The band gap energies of CGS （A, B, and C bands） were measured to be 1.73, 1.83, and 2.04 eV at liquid nitrogen temperature, respectively. The A band was clearly obtained from 5 to 300 K, and the temperature dependence of the peak energy was fitted with the modified Manoogian–Woolley equation. PPA signals for CGS/GaAs （001） epitaxial layers were obtained between liquid helium and room temperature.The following article appeared in Applied Physics Letters. 7/10/2000, Vol. 77 Issue 2 P.259 and may be found at http://dx.doi.org/10.1063/1.12694

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

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崎戸炭田淺浦鑛區開發計画

東京帝国大学工科大学種別:卒業論文thesi

徂徠『論語徴』について（二）

1978-03departmental bulletin pape

Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans

YidC, a member of the YidC/Oxa1/Alb3 family, inserts proteins into the membrane and facilitates membrane-protein folding in bacteria. YidC plays key roles in both Sec-mediated integration and Sec-independent insertion of membrane proteins. Here, {\it Bacillus halodurans} YidC2, which has five transmembrane helices conserved among the other family members, was identified as a target protein for structure determination by a fluorescent size-exclusion chromatography analysis. The protein was overexpressed, purified and crystallized in the lipidic cubic phase. The crystals diffracted X-rays to 2.4{\AA} resolution and belonged to space group {\it P}2{\sb 1}, with unit-cell parameters {\it a} = 43.9, {\it b} = 60.6, {\it c} = 58.9{\AA}, {$\beta$} = 100.3{$^\circ$}. The experimental phases were determined by the multiwavelength anomalous diffraction method using a mercury-derivatized crystal.journal articl

偏心円孔を有する帯板の引張り : 調和変位関数に基づく解析

This paper presents an analytical solution for an infinite strip having an eccentric circular hole when the strip is subjected to tension at infinity. The analysis is based on the Papcovich-Neuber potential approach and the solution is obtained by the proper combination of harmonic function in integral forms and infinite series. The boundary conditions both on edge of the strip and on the hole are satisfied using the relations between the polar and Cartesian harmonics. The numerical results obtained are compared with those of existing solutions. A detailed stresses around the hole are illustrated for various sizes of the eccentricity and the hole.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110004997347/textapplication/pdfjournal articl