Histologic, immunohistochemical, and in situ hybridization study of myxoid stroma in feline oral squamous cell carcinoma

Oral squamous cell carcinoma (oSCC) is a highly invasive malignant neoplasm in cats. Recently, tumor stroma, known as tumor microenvironments, have been considered to play an essential role in tumor progression. However, their role in feline squamous cell carcinoma (SCC) remains unclear. This study aimed to reveal the cancer microenvironment of feline oSCC and evaluate the pathological mechanisms of progression. We used 19 samples from 17 cats with oSCC, which were examined using light microscopy, immunohistochemistry, and in situ hybridization (RNAscope®). Feline oSCCs had two types of stroma, namely fibrotic and myxoid stromal reaction patterns, which were easily distinguished using hematoxylin-eosin staining. The myxoid stroma was rich in hyaluronic acid, which seems to be produced by neoplastic cells. Furthermore, the presence of myxoid stroma was correlated with histological parameters, including the appearance of cancer-associated fibroblasts and tumor budding. Periostin protein expression was also frequently observed in the stroma of feline oSCC and was significantly more common in the myxoid stromal reaction pattern group than in the fibrotic group. Positive signals for periostin mRNA were detected in stromal cancer-associated fibroblasts. This study indicates that the interaction between neoplastic cells and stromal reaction pattern components, such as hyaluronic acid and periostin, may be involved in tumor malignancy. Therefore, we propose that focus be placed not only on the tumor tissue but also on the characterization of the stroma for analyzing feline oSCC.journal articl

Temperature variation of nonradiative carrier recombination processes in high-quality CuGaSe_2 thin films grown by molecular beam epitaxy

The piezoelectric photoacoustic （PPA） measurements for Cu-rich CuGaSe_2 （CGS）/GaAs（001） epitaxial layer were carried out between liquid helium and room temperatures. The band gap energies of CGS （A, B, and C bands） were measured to be 1.73, 1.83, and 2.04 eV at liquid nitrogen temperature, respectively. The A band was clearly obtained from 5 to 300 K, and the temperature dependence of the peak energy was fitted with the modified Manoogian–Woolley equation. PPA signals for CGS/GaAs （001） epitaxial layers were obtained between liquid helium and room temperature.The following article appeared in Applied Physics Letters. 7/10/2000, Vol. 77 Issue 2 P.259 and may be found at http://dx.doi.org/10.1063/1.12694

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

Catálogo Normas Legales Diario Oficial El Peruano, Dic. 1980 - Dic. 1985

Declaran Monumento Histórico el local del antiguo Colegio Nacional "San Juan de Chota". Documento que forma parte del "Catálogo de normas legales. Una mirada del Sector Cultura desde el Boletín del Diario El Peruano, Dic. 1980 - Dic. 1985"

＜研究ノート＞状況に埋め込まれた学習としてのイノベーション : 新しい文化を生む際の「価値の生産と推進」について : セルフグリル・レストラン『ゲッコ』の変遷より

本稿は，経済における革新とは、生産側・消費側両者の相互作用による両者の教授・学習がイノベーションをもたらすとの考えに基づく。新しいモノの価値の生産とは，単に新しいモノを開発するだけではなく、新しい文化・欲望をつくることであり、それによって新たな需要が生まれることを示す。本研究は、筆者が行ったレストランの開発・運営の変遷を調査対象とした。変遷の記述・分析から、新しい文化を生む際に、「提案する者（生産側）」と「選択する者（消費側）」とされる両者の共同体が学び合う相互作用が示された。店舗を経営者とスタッフ側だけでなく顧客も含んだ共同体と捉え、店舗と顧客との相互作用の中で共に変化して行く過程を記述した。この共同体の変化の中で即興的・流動的に新しい価値・文化を生産し推進して行く過程を検証している。This paper shows that producing values of new objects is not only just developing new things but also creating new cultures and desires, and it brings new demands. The innovation on economy might be established on the collective learning process through interactions by producers and consumers. The field of this research was a restaurant whose owner is the author of this article and a subject of investigation was the process of development and management of the restaurant. Data showed the interactions between “proposers; producers” and “selectors; consumers” were the collective learning process on which new culture had been creating. This research considered the restaurant as the learning community being constructed by not only a manager and employees but also customers, and described a process of changing thorough the interactions among this community. The process was verified that the community fluidly and improvisation-ally produced and advanced the new value and culture.departmental bulletin pape

熊野古道地域における眺望景観保全制度に関する研究

application/pdf三重大学大学院工学研究科博士前期課程建築学専攻458thesi

trachycaulus

Elymus trachycaulus (Link) Gould ex Shinners subsp. trachycaulusslender wildryeélyme à chaumes rudesAgropyron trachycaulumtributary of Milk River 2.1 km SSW of Coffin BridgeDry mixed grassland: prairie incised river valley - shaded coulee basin3275 feetin mesic thicket of Salix - Rosa - Elaeagnusglumes with 3 to 4 veins, anther ca 1 mm lon

二瀬炭坑採炭計画

東京帝国大学工科大学種別:卒業論文thesi

李氏蔵書について（二）

1981-03departmental bulletin pape

Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans

YidC, a member of the YidC/Oxa1/Alb3 family, inserts proteins into the membrane and facilitates membrane-protein folding in bacteria. YidC plays key roles in both Sec-mediated integration and Sec-independent insertion of membrane proteins. Here, {\it Bacillus halodurans} YidC2, which has five transmembrane helices conserved among the other family members, was identified as a target protein for structure determination by a fluorescent size-exclusion chromatography analysis. The protein was overexpressed, purified and crystallized in the lipidic cubic phase. The crystals diffracted X-rays to 2.4{\AA} resolution and belonged to space group {\it P}2{\sb 1}, with unit-cell parameters {\it a} = 43.9, {\it b} = 60.6, {\it c} = 58.9{\AA}, {$\beta$} = 100.3{$^\circ$}. The experimental phases were determined by the multiwavelength anomalous diffraction method using a mercury-derivatized crystal.journal articl