Intellectual trends in recent American literature

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Histologic, immunohistochemical, and in situ hybridization study of myxoid stroma in feline oral squamous cell carcinoma

Oral squamous cell carcinoma (oSCC) is a highly invasive malignant neoplasm in cats. Recently, tumor stroma, known as tumor microenvironments, have been considered to play an essential role in tumor progression. However, their role in feline squamous cell carcinoma (SCC) remains unclear. This study aimed to reveal the cancer microenvironment of feline oSCC and evaluate the pathological mechanisms of progression. We used 19 samples from 17 cats with oSCC, which were examined using light microscopy, immunohistochemistry, and in situ hybridization (RNAscope®). Feline oSCCs had two types of stroma, namely fibrotic and myxoid stromal reaction patterns, which were easily distinguished using hematoxylin-eosin staining. The myxoid stroma was rich in hyaluronic acid, which seems to be produced by neoplastic cells. Furthermore, the presence of myxoid stroma was correlated with histological parameters, including the appearance of cancer-associated fibroblasts and tumor budding. Periostin protein expression was also frequently observed in the stroma of feline oSCC and was significantly more common in the myxoid stromal reaction pattern group than in the fibrotic group. Positive signals for periostin mRNA were detected in stromal cancer-associated fibroblasts. This study indicates that the interaction between neoplastic cells and stromal reaction pattern components, such as hyaluronic acid and periostin, may be involved in tumor malignancy. Therefore, we propose that focus be placed not only on the tumor tissue but also on the characterization of the stroma for analyzing feline oSCC.journal articl

駐車場所－駐車時間選択行動への離散－連続選択モデルの適用と駐車料金施策分析

In the central city area, the vehicles queuing to the parking lot and/or illegally parked on-street cause serious road traffic congestion. This study develops discrete-continuous choice model of parking location and duration in order to better understanding drivers’ parking behavior. We apply a simultaneous estimation technique to overcome an inconsistency of a conventional estimation result, and apply WESML estimator because of choice-based sample obtained from mail-in survey. As a result of the analysis concerning the parking price discount measure for reducing the illegal parking on-street, it was shown that the results with a discrete-continuous choice model were greatly different from those with a usual MNL model and a regression model.journal articl

Temperature variation of nonradiative carrier recombination processes in high-quality CuGaSe_2 thin films grown by molecular beam epitaxy

The piezoelectric photoacoustic （PPA） measurements for Cu-rich CuGaSe_2 （CGS）/GaAs（001） epitaxial layer were carried out between liquid helium and room temperatures. The band gap energies of CGS （A, B, and C bands） were measured to be 1.73, 1.83, and 2.04 eV at liquid nitrogen temperature, respectively. The A band was clearly obtained from 5 to 300 K, and the temperature dependence of the peak energy was fitted with the modified Manoogian–Woolley equation. PPA signals for CGS/GaAs （001） epitaxial layers were obtained between liquid helium and room temperature.The following article appeared in Applied Physics Letters. 7/10/2000, Vol. 77 Issue 2 P.259 and may be found at http://dx.doi.org/10.1063/1.12694

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

The effectiveness of sensitivity training focusing on emotional attunement to infants and children : for graduate students of clinical psychology

Training institutes, including graduate schools for clinical psychology have been producing qualified and skilled clinical psychologists in society. In order to become good clinical psychologists, the candidates need to have not only knowledge and skills in the subject area but should also have personal characteristics such as sensitivity, empathy, and introspection. In this study a sensitivity training program, which focused on emotional attunement to infants and children, was developed and its effectiveness was investigated using three questionnaires : the perceived coding ability scale, the interpersonal sensitivity measure, and the non-verbal sensitivity scale. Out of 60 graduate students, 18 participated in this program once a week at a nursery school for a period of 5 months. The results showed that the scores of the perceived coding ability scale were significantly increased for students who participated in this program but there was no difference in the scores of the other two scales. The results also showed that there were significant differences between the scores of students who participated in the program and those who did not, with respect to the perceived coding ability and interpersonal sensitivity scales. Students who participated in this program showed higher sensitivity scores even before participating in this program. Therefore, we concluded that the program needs to focus more on emotional attunement and the selection process must change such that all students participate in this program.departmental bulletin pape

Fe/MgO接合をベースとした強磁性遷移金属薄膜の構造と垂直磁気異方性

application/pdf三重大学大学院工学研究科博士前期課程物理工学専攻91thesi

新入炭坑発展計画

東京帝国大学工科大学種別:卒業論文thesi

Additional file 1 of Rainfall driven and wild-bird mediated avian influenza virus outbreaks in Australian poultry

Additional file

Full Wader Gene Tree

Phylogeny of waders used in phylogenetic comparative analyses. Gene sequences uploaded in the Oikos supplementary files were used to create a Bayesian consensus tree. Wader species without molecular data were grafted onto the consensus tree as polytomies using taxonomic information