Thrombin induces MCP-1 and MMP-3 production and disc degeneration via PAR1 on mouse intervertebral disc

University of Yamanashi (山梨大学)博士(医学)医工博4甲第226号thesi

Jacobean playwrights and women

表紙・目次のタイトル: Jacobean dramatists and women表紙・目次の著者名: Pendley, Eric D.application/pdfdepartmental bulletin pape

Comparative analysis based on shared amplicon sequence variants reveals that cohabitation influences gut microbiota sharing between humans and dogs

Introduction: The One Health concept is a comprehensive understanding of the interaction between humans, animals, and the environment. The cohabitation of humans and pets positively affects their physical, mental, and social well-being. It is recognized as an essential factor from the One Health perspective. Furthermore, a healthy balance in the gut microbiome is essential for good health, and the changes in the gut microbiome associated with cohabitation between humans and pets could potentially affect various aspects of the health of both hosts. Therefore, elucidating the sharing of gut bacteria between humans and pets associated with cohabitation is important for understanding One Health. However, most studies have examined sharing at the taxonomic level, and it remains unclear whether the same bacteria are transferred between humans and pets, and whether they mutually influence each other. Methods: Here, microbiome analysis and shared 16S rRNA gene amplicon sequence variant (ASV) analysis were conducted before the start of cohabitation between humans and dogs, as well as at 2 weeks, 1 month, and 3 months after cohabitation. Results: 16S rRNA gene ASVs analysis indicated that gut microbes have been transferred between humans and dogs. The overall structure of the gut microbiota within human–dog pairs remained unchanged after 3 months of adaptation. However, 11ASVs were shared within human–dog pairs. Many shared ASVs were highly abundant within each host, and this high abundance may be considered a factor that influences bacterial transfer between hosts. Discussion: Our results provide important insights into the potential for the transfer of gut bacteria between humans and dogs. These findings are considered crucial for understanding the impact of human–dog cohabitation on various aspects of health.journal articl

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

The effectiveness of sensitivity training focusing on emotional attunement to infants and children : for graduate students of clinical psychology

Training institutes, including graduate schools for clinical psychology have been producing qualified and skilled clinical psychologists in society. In order to become good clinical psychologists, the candidates need to have not only knowledge and skills in the subject area but should also have personal characteristics such as sensitivity, empathy, and introspection. In this study a sensitivity training program, which focused on emotional attunement to infants and children, was developed and its effectiveness was investigated using three questionnaires : the perceived coding ability scale, the interpersonal sensitivity measure, and the non-verbal sensitivity scale. Out of 60 graduate students, 18 participated in this program once a week at a nursery school for a period of 5 months. The results showed that the scores of the perceived coding ability scale were significantly increased for students who participated in this program but there was no difference in the scores of the other two scales. The results also showed that there were significant differences between the scores of students who participated in the program and those who did not, with respect to the perceived coding ability and interpersonal sensitivity scales. Students who participated in this program showed higher sensitivity scores even before participating in this program. Therefore, we concluded that the program needs to focus more on emotional attunement and the selection process must change such that all students participate in this program.departmental bulletin pape

自己ドープ型ポリマーと二酸化チタンとの複合体：合成と機能発現

application/pdf三重大学大学院工学研究科博士前期課程分子素材工学専攻172thesi

日立鉱山採鉱計画

東京帝国大学工科大学種別:卒業論文thesi

「心」の哲学

1988-03departmental bulletin pape

Conformational variation of the translocon enhancing chaperone SecDF

The Sec translocon facilitates transportation of newly synthesized polypeptides from the cytoplasm to the lumen/periplasm across the phospholipid membrane. Although the polypeptide-conducting machinery is formed by the SecYEG-SecA complex in bacteria, its transportation efficiency is markedly enhanced by SecDF. A previous study suggested that SecDF assumes at least two conformations differing by a 120° rotation in the spatial orientation of the P1 head subdomain to the rigid base, and that the conformational dynamics plays a critical role in polypeptide translocation. Here we addressed this hypothesis by analyzing the 3D structure of SecDF using electron tomography and single particle reconstruction. Reconstruction of wt SecDF showed two major conformations; one resembles the crystal structure of full-length SecDF (F-form structure), while the other is similar to the hypothetical structural variant based on the crystal structure of the isolated P1 domain (I-form structure). The transmembrane domain of the I-form structure has a scissor like cleft open to the periplasmic side. We also report the structure of a double cysteine mutant designed to constrain SecDF to the I-form. This reconstruction has a protrusion at the periplasmic end that nicely fits the orientation of P1 in the I-from. These results provide firm evidence for the occurrence of the I-form in solution and support the proposed F- to I-transition of wt SecDF during polypeptide translocation.journal articl

機械工学年鑑(1997年) : 機械力学・計測制御

rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002383896/textapplication/pdfjournal articl