Association of inherited genetic variants with glucocorticoid sensitivity and glucocorticoid receptor expression in B-cell precursor acute lymphoblastic leukemia

University of Yamanashi (山梨大学)博士(医学)医工博4甲第234号thesi

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

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阿部城鉱山発展計画

東京帝国大学工科大学種別:卒業論文thesi

平面図形の奥行視における、みえの大きさ、みえの距離、図形の場強の関係の実験的検討

1979-03The present study was concerned with the depth perception of bidimensional pattern. The author's attempt was to integrate bidimensional and tridimensional visual phenomena from a field-theoretical point of view. Experiment Ⅰ measured the distance perceived between observer and planes of the depth pattern by asking the subject to match the apparent distance of them with a frame pattern simultaneously presented to him. Experiment Ⅱ, dealing with the size-distance invariance, correlated the perceived size with the perceived distance of each plane in the depth pattern. The result confirmed the invariance. Experiment Ⅲ examined the relation between the field force and the perceived distance by the light-threshold method. The threshold of a small point projected on the plane varied with the perceived distance of the plane, showing a linear function of it. These findings were compared with previous reports by Motokawa et al.(1956), Hara(1970), and Nozawa(1971), mentioning possible factors producing the discrepancy and consistency in the results.departmental bulletin pape

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

Proton-dependent oligopeptide transporters (POTs) are major facilitator superfamily (MFS) proteins that mediate the uptake of peptides and peptide-like molecules, using the inwardly directed H+ gradient across the membrane. The human POT family transporter peptide transporter 1 is present in the brush border membrane of the small intestine and is involved in the uptake of nutrient peptides and drug molecules such as β-lactam antibiotics. Although previous studies have provided insight into the overall structure of the POT family transporters, the question of how transport is coupled to both peptide and H+ binding remains unanswered. Here we report the high-resolution crystal structures of a bacterial POT family transporter, including its complex with a dipeptide analog, alafosfalin. These structures revealed the key mechanistic and functional roles for a conserved glutamate residue (Glu310) in the peptide binding site. Integrated structural, biochemical, and computational analyses suggested a mechanism for H+-coupled peptide symport in which protonated Glu310 first binds the carboxyl group of the peptide substrate. The deprotonation of Glu310 in the inward open state triggers the release of the bound peptide toward the intracellular space and salt bridge formation between Glu310 and Arg43 to induce the state transition to the occluded conformation.journal articl

Analysis of anions in canine serum using a polyvinyl alcohol (PVA) capillary

<p><b>Copyright information:</b></p><p>Taken from "Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions"</p><p>http://ccforum.com/content/11/6/R130</p><p>Critical Care 2007;11(6):R130-R130.</p><p>Published online 14 Dec 2007</p><p>PMCID:PMC2246228.</p><p></p> The retention times for some other organic anions not detected in canine blood serum are indicated. The peak at 6.283 minutes remains unidentified. The detection limits were as follows: acetate 1.0 mmol/L, α-ketoglutarate 10.0 μmol/L, citrate 0.1 mmol/L, fumarate 1.0 μmol/L, β-hydroxybutyrate 0.7 mmol/L, and urate 0.1 μmol/L. The conditions were as follows: PVA capillary (60 cm × 50 μm internal diameter); phosphate buffer, pH 7.0; running voltage, 20 kV; 25°C; detection: UV light absorption at 214 nm; sample: canine serum diluted with distilled water (1:100)

機械工学年鑑(1997年) : 機械力学・計測制御

rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002383896/textapplication/pdfjournal articl