Myocardial Production of Plasminogen Activator Inhibitor-1 is Associated with Coronary Endothelial and Ventricular Dysfunction after Acute Myocardial Infarction

University of Yamanashi (山梨大学)博士(医学)医工博4甲第235号doctoral thesi

God bless America

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EN-ROUTE UPDATING METHODOLOGY OF TRAVEL TIME PREDICTION USING ACCUMULATED PROBE-CAR DATA

Probe-car data include the information about the trajectory of speeds driver have experienced while passing through arbitrary selected sections. This paper discusses the methods of en-route updating travel time prediction, making effective use of probe-car data. Several methods suggested in this paper, which are en-route updating methods using both accumulated probe-car data and driver-experienced data, can predict travel time more accurately than methods that do not use both data in most cases.CD-ROMjournal articl

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

花岡鉱山採鉱計画

東京帝国大学工科大学種別:卒業論文thesi

車両前方映像中の道路標識の認識

application/pdf三重大学大学院工学研究科博士前期課程情報工学専攻38thesi

磁性流体を潤滑剤として用いたジャーナル軸受の静特性

The theoretical model for the velocity profile of the magnetic fluid film of journal bearings in the inhomogeneous magnetic field created by annular magnets is developed taking account of the rotation of magnetic particles in the suspension. The influence of the magnetic field on magnetic fluid in the bearing dominantly appears in the increase of the effective viscosity and leads to the variation of the velocity. According to this result, the static characteristics of this type of journal bearings are calculated under the hypothesis of infinitely long bearings. It is known that the load capacity is improved with the increase of the magnetic intensity, the saturation magnetization intensity and the dimension of magnetic particles; but the shaft center locus remains nearly the same as ordinary bearings. It is also known that a suitable combination of base fluid viscosity and magnetic fluid viscosity can reach a maximum load copacity under a certain magnetic field intensity.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002383948/textapplication/pdfjournal articl

Quantitative meta-analysis of survival in hyperoncotic albumin compared with control group

Data points are scaled in proportion to meta-analytic weight. CI, 95% confidence interval; RR, relative risk.<p><b>Copyright information:</b></p><p>Taken from "Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials"</p><p>http://ccforum.com/content/12/2/R34</p><p>Critical Care 2008;12(2):R34-R34.</p><p>Published online 4 Mar 2008</p><p>PMCID:PMC2447554.</p><p></p

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

Proton-dependent oligopeptide transporters (POTs) are major facilitator superfamily (MFS) proteins that mediate the uptake of peptides and peptide-like molecules, using the inwardly directed H+ gradient across the membrane. The human POT family transporter peptide transporter 1 is present in the brush border membrane of the small intestine and is involved in the uptake of nutrient peptides and drug molecules such as β-lactam antibiotics. Although previous studies have provided insight into the overall structure of the POT family transporters, the question of how transport is coupled to both peptide and H+ binding remains unanswered. Here we report the high-resolution crystal structures of a bacterial POT family transporter, including its complex with a dipeptide analog, alafosfalin. These structures revealed the key mechanistic and functional roles for a conserved glutamate residue (Glu310) in the peptide binding site. Integrated structural, biochemical, and computational analyses suggested a mechanism for H+-coupled peptide symport in which protonated Glu310 first binds the carboxyl group of the peptide substrate. The deprotonation of Glu310 in the inward open state triggers the release of the bound peptide toward the intracellular space and salt bridge formation between Glu310 and Arg43 to induce the state transition to the occluded conformation.journal articl