Somatosensory evoked potentials of the tibial nerve during the surgical decompression of thoracolumbar intervertebral disk herniation in dogs

This study aimed to identify the impact on spinal cord integrity and determine the electrophysiological safety level during surgery for thoracolumbar intervertebral disk herniation in dogs. A total of 52 dogs diagnosed with thoracolumbar intervertebral disk herniation were enrolled. The tibial nerve somatosensory evoked potential elicited on the scalp by stimulation of the tibial nerve was recorded before and during hemilaminectomy. Both the amplitude and latency of the somatosensory evoked potential were periodically registered, and the percentage changes from the pre-operative control values (amplitude rate and latency rate) were calculated. When the multifidus muscles were retracted after removal from the spinous processes and vertebrae, the somatosensory evoked potential amplitude rate decreased in all dogs, while the latency rate increased in 33 dogs examined. The amplitude rate remained unchanged during the halting procedure, loosening retraction, and hemilaminectomy. After removing the disc material from the spinal canal, the amplitude rate was increased. The somatosensory evoked potential latency increased when the multifidus muscles were retracted and shortened after multifidus muscles closure in four cases. The outcome of all cases showed improvement in clinical signs 7 days after operation. Spinal cord conduction is impaired by retraction of the multifidus muscles and improved by removal of disk materials. Maintaining intraoperative SEP amplitudes above 50% of control may help avoid additional spinal cord injury during surgery. Since we have no case that worsened after the surgery, however, further studies are necessary to confirm this proposal.journal articl

EN-ROUTE UPDATING METHODOLOGY OF TRAVEL TIME PREDICTION USING ACCUMULATED PROBE-CAR DATA

Probe-car data include the information about the trajectory of speeds driver have experienced while passing through arbitrary selected sections. This paper discusses the methods of en-route updating travel time prediction, making effective use of probe-car data. Several methods suggested in this paper, which are en-route updating methods using both accumulated probe-car data and driver-experienced data, can predict travel time more accurately than methods that do not use both data in most cases.CD-ROMjournal articl

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

神岡鉱山採鉱計画

東京帝国大学工科大学種別:卒業論文thesi

GC-MS技術による工場地区環気の汚染構成の解明

application/pdfpostprintThe technique of gas chromatography-mass spectrometry was applied to the analysis of air pollutants around several factories, such as petrochemical, kraft pulp and paint industries. the samples of 200l were adsorpted on fire brick by cooling with liquid oxygen and injected to GC-MS according the ordinary GC operation.As the results of these researches, it was found that the pollutants below ppb were definitely identified and these were also the materials that were usually treated in the manufacturing process in each factory. For example, in case of Kawasaki city, lehihara city and Yoshihara city, acetaldehyde, acetone, methyl alcohol, ethyl alcohol, propyl alcohol, butyl alcohol, methyl ethyl ketone, methyl isobutyl ketone, ethyl acetate, n-butyl acetate, methyl methacrylate, ethyl acrylalc, trichloro fluoro methane, chloro ethane, trichloro trifluoro cthane, dichloro mono fluoro methane, dichloro ethylene, trichloro methane, carbon-tetrachloride, diehloro ethane, tetrachloro ethylene, benzene, toluene, xylene, 1,3-butadiene and other hydrocarbons were detected.departmental bulletin pape

小型発電機用スターリングエンジンの開発に関する基礎研究 : (第2報, シミュレーション計算によるエンジンの性能予測法)

A 100W Stirling engine was developed as a prime mover of a portable generator set. Special bayonet-type heat exchangers whose inner tubes move inside of the outer tubes, were applied for the engine's heater and cooler. An annular regenerator was located in a displacer piston. The engine had already achieved the target performance. To improve the engine performance efficiently, a simulation model for the prototype engine was developed. The pressure in the working space was analyzed by an isothermal analysis which takes into account a gas leakage between the buffer space and working space, and a pressure losses in the heat exchangers. For the pressure loss in the regenerator, the model can treat the effects by the velocity distribution in the regenerator matrix. To estimate the engine output, the model calculates the mechanical loss and the buffer loss which is caused by a pressure change in the buffer space. The buffer loss was calculated with three models, an isothermal, an adiabatic and a simple heat transfer model to determine a suitable model for the buffer space. The analysis results were compared with the experimental deta carefully.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002396974/textapplication/pdfjournal articl

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

Proton-dependent oligopeptide transporters (POTs) are major facilitator superfamily (MFS) proteins that mediate the uptake of peptides and peptide-like molecules, using the inwardly directed H+ gradient across the membrane. The human POT family transporter peptide transporter 1 is present in the brush border membrane of the small intestine and is involved in the uptake of nutrient peptides and drug molecules such as β-lactam antibiotics. Although previous studies have provided insight into the overall structure of the POT family transporters, the question of how transport is coupled to both peptide and H+ binding remains unanswered. Here we report the high-resolution crystal structures of a bacterial POT family transporter, including its complex with a dipeptide analog, alafosfalin. These structures revealed the key mechanistic and functional roles for a conserved glutamate residue (Glu310) in the peptide binding site. Integrated structural, biochemical, and computational analyses suggested a mechanism for H+-coupled peptide symport in which protonated Glu310 first binds the carboxyl group of the peptide substrate. The deprotonation of Glu310 in the inward open state triggers the release of the bound peptide toward the intracellular space and salt bridge formation between Glu310 and Arg43 to induce the state transition to the occluded conformation.journal articl

Clinical efficacy and tolerability of zonisamide monotherapy in dogs with newly diagnosed idiopathic epilepsy: Prospective open‐label uncontrolled multicenter trial

Abstract Background Zonisamide (ZNS) is a newer generation antiseizure medication (ASM) used to treat epilepsy in dogs and cats. However, scientific and clinical information, particularly regarding monotherapy, is limited. Objectives To evaluate the antiseizure efficacy and tolerability of ZNS monotherapy in dogs with newly diagnosed idiopathic epilepsy (IE). Animals Study included 56 client‐owned dogs newly diagnosed with IE. Methods This was a prospective multicenter, open‐label, uncontrolled study. All dogs were ASM‐naïve and had ≥2 seizures within 12 weeks. Dogs were administered 2.7‐14.4 mg/kg ZNS PO q12h and followed up for ≥12 weeks. Data from the 12‐week maintenance treatment period were compared with those from the 4‐ to 12‐week pretreatment period for efficacy evaluation. Data from the entire ZNS administration period were used to assess tolerability. Results Fifty‐six dogs were included in our study. Of the dogs, 53 were assessed for efficacy; 40 (76%) had a ≥ 50% reduction in seizure frequency, and 29 (55%) achieved seizure freedom. For 90% of the dogs with ≥50% reduction in seizure frequency, the mean ZNS dose was 4.8 (range, 2.7‐8.6) mg/kg q12h and the mean trough plasma ZNS concentration was 18.9 (range, 8.0‐48.0) μg/mL. In 7 of the 56 dogs (13%), reduced activity, decreased appetite, vomiting, hindlimb weakness, soft stools, or constipation was observed, albeit mild and temporary. Laboratory tests revealed no relevant changes. Conclusions and Clinical Importance Our study suggests that ZNS monotherapy is effective and well‐tolerated in dogs with newly diagnosed IE