Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression

University of Yamanashi (山梨大学)博士(医学)医工博4甲第240号doctoral thesi

Effect of feeding spent coffee grounds on the methane production in bovine rumen

The environmental impact of methane, a greenhouse gas emitted from ruminants, is a pressing issue and methods to control methane emissions from ruminants are being investigated worldwide. In this study, we investigated the effects of the administration of spent coffee grounds (SCG) on methane production in the rumen in two cows. In the control condition (days 1 and 2), the cows were fed a basic diet twice daily (roughage and concentrate), and in the SCG condition (days 1 and 2) sequentially, the cows were fed the same basic diet and administered SCG into the rumen twice daily. The methane and carbon dioxide concentrations in rumen gas were measured via a fistula after feeding on days 2 in both cases of the study. The measurements were made using a newly developed gas measurement system with a portable gas monitor, and data were obtained for the control condition and SCG condition at each measurement time. The methane ratio at each measurement time was calculated from the methane and carbon dioxide concentrations, and compared between the two conditions. Statistical analysis showed no significant difference between the two conditions in the methane ratios after the morning (P=0.108) and afternoon feedings (P=0.345). However, the methane ratios before the morning (P=0.043) and afternoon feedings (P=0.008) were significantly lower in the SCG condition than in the control condition, suggesting that the administration of SCG may suppress methane production in the rumen.journal articl

Actin Migration Driven by Directional Assembly and Disassembly of Membrane-Anchored Actin Filaments

Actin and actin-associated proteins migrate within various cell types. To uncover the mechanism of their migration, we analyzed actin waves, which translocate actin and actin-associated proteins along neuronal axons toward the growth cones. We found that arrays of actin filaments constituting waves undergo directional assembly and disassembly, with their polymerizing ends oriented toward the axonal tip, and that the lateral side of the filaments is mechanically anchored to the adhesive substrate. A combination of live-cell imaging, molecular manipulation, force measurement, and mathematical modeling revealed that wave migration is driven by directional assembly and disassembly of actin filaments and their anchorage to the substrate. Actin-associated proteins co-migrate with actin filaments by interacting with them. Furthermore, blocking this migration, by creating an adhesion-free gap along the axon, disrupts axonal protrusion. Our findings identify a molecular mechanism that translocates actin and associated proteins toward the cell’s leading edge, thereby promoting directional cell motility.journal articl

Improved Search for νμ→νe Oscillation in a Long-Baseline Accelerator Experiment

journal articl

造船における上向き作業支援装置の開発

application/pdf三重大学大学院工学研究科博士前期課程機械工学専攻42thesi

三菱相知炭坑計画

東京帝国大学工科大学種別:卒業論文thesi

ガンダーラ涅槃図の読解

1989-03departmental bulletin pape

環境埋め込み情報に基づく自律移動ロボットの自己位置同定

Generally, in the self-localization method based on positions of landmarks, it is necessary for robots to manage the maps of the landmarks. In multiple robot systems, it is, however, difficult to keep the consistency among all the maps carried by the robots when the maps are updated frequently and dynamically. In this paper, we introduce Intelligent Data Carriers (IDCs) to realize map-free self-localization in multiple robot systems. The IDC is a portable data management device developed at RIKEN. By putting an IDC in the work area and storing its own position data in itself, robots can acquire the position of the IDC using local communication without refering to any maps. Detalied procedures to acquire and integrate various information are presented. The efficiency of the proposed method are discussed based on the results of the experiments. It is confirmed that this method is available for the robot to localize its own position in multiple robot environment.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002383632/textapplication/pdfjournal articl