Conjugate Acid–Base Catalysts for Highly Enantioselective Organozinc Addition to Carbonyl Compounds

名古屋大学Nagoya University博士(工学)名古屋大学博士学位論文 学位の種類:博士(工学) (課程) 学位授与年月日:平成19年3月23日doctoral thesi

Preclinical/clinical trials of thrice-weekly administration of a combination of tegafur/gimeracil/oteracil (TS-1) and toceranib phosphate in dogs with intranasal tumors

Intranasal tumors in dogs are malignant solid tumors that are primarily treated with radiotherapy and often recur post-treatment. Combination therapy is pivotal in cancer therapy. Effective drugs include fluoropyrimidine 5-fluorouracil (5-FU) and toceranib phosphate. TS-1, an oral formulation containing the 5-FU prodrug tegafur and enzyme modulators gimeracil and oteracil, is proven to be safe in dogs with solid tumors. While the oral drug toceranib phosphate (Palladia®) is safely administered, the combined toxicity with TS-1 is unknown. We aimed to determine the dosage of this combination in dogs. In the preclinical/clinical trials conducted here, we used a standard 3+3 cohort design with fixed doses of toceranib phosphate (2.4 mg/kg) administered thrice weekly. TS-1 administration was initiated at a dose of 0.5 mg/kg (upper limit 2.0 mg/kg) thrice weekly. Four cohorts were included to confirm the safety of TS-1 and toceranib phosphate. Each cohort was followed up for 1 month. The intranasal tumor types included in the clinical trial (n=13) were adenocarcinoma (n=7), squamous cell carcinoma (n=1), non-epithelial malignancy (n=2), undifferentiated carcinoma (n=1), and transitional carcinoma (n=2). The TS-1 dosage could be increased up to its dose limit in the preclinical/clinical trials. The TS-1 dose to combine with toceranib phosphate thrice weekly was 2.0 mg/kg. This regimen was well-tolerated in dogs. Thus, combined TS-1 and toceranib phosphate therapy is safe for dogs with intranasal tumors.journal articl

Measurement of the Branching Fraction, Polarization, and CP Asymmetry for B0→ρ+ρ- Decays, and Determination of the Cabibbo-Kobayashi-Maskawa Phase ϕ2

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タンパク質による前濃縮法を用いた環境試料中微量金属の電気加熱原子吸光分析

application/pdf三重大学大学院工学研究科博士前期課程分子素材工学専攻87thesi

0812-9869-9940 (WA), Jual Keranda Mayat Baki

<p>0812-9869-9940 (WA), Jual Keranda Mayat Baki@@Jual Keranda Mayat Baki, Jual Keranda Mayat Panyingkiran, Jual Keranda Mayat Warureja, Jual Keranda Mayat Bansari, Jual Keranda Mayat Bejen, Jual Keranda Mayat Candiroto, Jual Keranda Mayat Gemawang, Jual Keranda Mayat Jumo, Jual Keranda Mayat Kaloran@@keranda jenazah 1 set promo @keranda mayat dan pemandian sepaket@keranda awet kokoh anti karat@paket keranda murah@paket keranda jenazah dan pemandian 1 paket@keranda paket@paket pemandian jenazah dan keranda@pemandian jenazah@GRATIS KAIN PENUTUP KERANDA@Menyediakan berbagai kebutuhan kepengurusan jenazah@@Dengan material stainless steel, kami memproduksi KERANDA JENAZAH dan PEMANDIAN JENAZAH yang mana ANTI KARAT, KOKOH, dan JELAS KEAWETANNYA.@@Memudahkan bagi jamaah sekalian dalam kepengurusan jenazah@Dibuat dari STAINLESS STEEL sehingga tahan karat dan aman disimpan dalam ruangan@Desain yang KOKOH mampu menahan berat hingga 300kg @@Spesifikasi Singkat:@-KERANDA@Bahan : Stainless Steel 201@Dimensi : Panjang 200 cm � Lebar 65 cm -Tinggi kurungan 64cm@Beban Maximum 300 kg@@-PEMANDIAN JENAZAH@Bahan : Stainless Steel 201@Dimensi : Panjang 205cm - Lebar 75cm - Tinggi 80cm@Beban MAX : 300KG@@@#JualKerandaMayatBaki, #JualKerandaMayatPanyingkiran, #JualKerandaMayatWarureja, #JualKerandaMayatBansari, #JualKerandaMayatBejen, #JualKerandaMayatCandiroto, #JualKerandaMayatGemawang, #JualKerandaMayatJumo, #JualKerandaMayatKaloran</p&gt

An Evolutionarily Conserved Plant RKD Factor Controls Germ Cell Differentiation

In contrast to animals, in which the germ cell lineage is established during embryogenesis, plant germ cells are generated in reproductive organs via reprogramming of somatic cells. The factors that control germ cell differentiation and reprogramming in plants are poorly understood. Members of the RKD subfamily of plant-specific RWP-RK transcription factors have been implicated in egg cell formation in Arabidopsis based on their expression patterns and ability to cause an egg-like transcriptome upon ectopic expression [1]; however, genetic evidence of their involvement is lacking, due to possible genetic redundancy, haploid lethality, and the technical difficulty of analyzing egg cell differentiation in angiosperms. Here we analyzed the factors that govern germ cell formation in the liverwort Marchantia polymorpha. This recently revived model bryophyte has several characteristics that make it ideal for studies of germ cell formation, such as low levels of genetic redundancy, readily accessible germ cells, and the ability to propagate asexually via gemma formation [2, 3]. Our analyses revealed that MpRKD, a single RWP-RK factor closely related to angiosperm RKDs, is preferentially expressed in developing eggs and sperm precursors in M. polymorpha. Targeted disruption of MpRKD had no effect on the gross morphology of the vegetative and reproductive organs but led to striking defects in egg and sperm cell differentiation, demonstrating that MpRKD is an essential regulator of germ cell differentiation. Together with previous findings [1, 4?6], our results suggest that RKD factors are evolutionarily conserved regulators of germ cell differentiation in land plants.journal articl

Utilization of Molten Slag into Interlocking Concrete Block (ILCB) in Japan and Recycling of 100% Molten Slag ILCB

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へん長回転だ円体状空かを有する半無限体の二軸一様引張り

へん長回転だ円体状空かを有する反無限体が二軸一様引張荷重を受ける問題を, 三次元弾性論に基づいて厳密に解析した. 解析においてはBoussinesqの応力関数にへん長回転だ円体調和関数および円柱調和関数を与え, 両者を互いに座標変換することにより半無限体表面ならびに空か面の境界じょうけんを同時に満足させた. そしてだ円体の形状比および長軸の大きさを変化させた場合について数値計算を行ない空か周辺の応力分布・応力集中を明らかにした.rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002375648/textapplication/pdfjournal articl