Die Situation der japanischen Gewerkschaften in der Zeit von 1965 bis 1971

application/pdfBulletin of University of Osaka Prefecture. Ser. D, Sciences of economy, commerce and law. 1972, 16, p.32-37departmental bulletin pape

Aberrant histone methylation in mouse early preimplantation embryos derived from round spermatid injection

Round spermatid injection (ROSI) is the last resort and recourse for men with nonobstructive azoospermia to become biological fathers of their children. However, the ROSI-derived offspring rate is lower than intracytoplasmic sperm injection (ICSI) in mice (20% vs. 60%). This low success rate has hindered the spread of ROSI in ART (Assisted Reproductive Technology). However, the cause of the ROSI-zygote-derived low offspring rate is currently unknown. In the previous studies, we reported that H3K9me3 and H3K27me3 exhibited ectopic localizations in male pronuclei (mPN) of ROSI-zygotes, suggesting that the carried over histone to zygotes conveys epigenetic information. In this study, we analyzed other histone modifications to explore unknown abnormalities. H3K36me3 showed an increased methylation state compared to ICSI-derived embryos but not for H3K4me3. Abnormal H3K36me3 was corrected until 2-cell stage embryos, suggesting a long window of reprogramming ability in ROSI-embryos. Treatment with TSA of ROSI-zygotes, which was reported to be capable of correcting ectopic DNA methylation in ROSI-zygotes, caused abnormalities of H3K36me3 in male and female PN (fPN) of the zygotes. In contrast, round spermatid TSA treatment before ROSI, which was reported to improve the preimplantation development of ROSI-zygotes, showed beneficial effects without toxicity in fPN. Therefore, the results suggest that TSA has some negative effects, but overall, it is effective in the correction of epigenetic abnormalities in ROSI-zygotes. When attempting to correct epigenetic abnormalities, attention should be paid to epigenomes not only in male but also in female pronuclei.journal articl

Measurement of the Branching Fraction, Polarization, and CP Asymmetry for B0→ρ+ρ- Decays, and Determination of the Cabibbo-Kobayashi-Maskawa Phase ϕ2

journal articl

二瀬炭砿報告及論文

東京帝国大学工学部種別:卒業論文thesi

中国語における発音指導の方法について－日本人学生の中国語発音の難点とその指導方法－

2008-03-31departmental bulletin pape

Supplementary Table 1 from Smoking, Lower Gastrointestinal Endoscopy, and Risk for Colorectal Cancer

PDF file - 31K, Association of regular smoking and type of colorectal cancer among cases and controls with no previous lower GI endoscopy and among cases and controls with utilization of lower GI endoscopy in the preceding 10 years.</p

Parental competition for the regulators of chromatin dynamics in mouse zygotes

Quantification of chromatin dynamics in paternal and maternal pronuclei reveals opposite effects on chromatin dynamics by oocyte- and sperm derived factors

大気中微量シアン化水素の濾紙による捕集について

application/pdfA new method for the collection of trace concentration of hydrogen cyanide in air was studied for the purpose of economizing the sampling time, Hydrogen cyanide was captured reacting with the reagent coated on a filter. Alkali and nickel salts were examined as the coating reagent. The most suitable filter for collection is prepared as follows. The filter ordinarily used for aerosol collection was dipped in an aqueous solution of ammoniacal nickel chloride (or nitrate). Then it was air-dried and stored in a desiccator which had been saturated with ammonia gas just before its use. The collection efficiency depended on the volume of sample air and was more than 95% when the air containing 5～200ppb hydrogen cyanide was led at avelocity of 5 meters per minute. It was hardly affected by variations of temperature and humidity and by the presence of sulfur dioxide or nitrogen dioxide in the concentration of the order of urban atmosphere. The recovery of hydrogen cyanide of ppb order ranged from 90 to 100%, when the sample air was led to the filter at flow rate of 200 liters per minute for 20minutes using high volume air sampler with sampling area of 400 c㎡.departmental bulletin pape

Baseline demographic and health-related behavior characteristics of breast cancer patients by lipid-lowering drug use at recruitment.

<p>Baseline demographic and health-related behavior characteristics of breast cancer patients by lipid-lowering drug use at recruitment.</p

Baseline tumor and treatment characteristics of breast cancer patients by lipid-lowering drug use at recruitment.

<p>Baseline tumor and treatment characteristics of breast cancer patients by lipid-lowering drug use at recruitment.</p