日本語会話データに見られる対比談話標識の使用実態

2008-03-31departmental bulletin pape

Improved Constraints on D0-D̅0 Mixing in D0→K+π- Decays from the Belle Detector

journal articl

The Potential of Bemegride as an Activation Agent in Electroencephalography in Dogs

The present study investigated the potential of bemegride as a pharmacological activation agent that elicits epileptiform discharges (EDs) in interictal electroencephalogram (EEG) recordings in dogs. Four laboratory dogs with idiopathic epilepsy and four without epilepsy were included. The dogs were anesthetized using sevoflurane during EEG recordings. Bemegride was administered intravenously and repeatedly until EDs were enhanced or induced, or until the maximum dose (20 mg/kg) had been administered. Bemegride activated EDs in all dogs with epilepsy. These EDs predominantly occurred in each dog’s spontaneous irritative zones, which were identified without the administration of bemegride. EDs occurred after the administration of bemegride in 50% of dogs without epilepsy. The dose required for activation was significantly lower in dogs with epilepsy (median; 7.3 mg/kg) than in those without (median; 19.7 mg/kg) (p = 0.0294). The only suspected adverse effect associated with the administration of bemegride was vomiting in two dogs after awakening from anesthesia. There were no other adverse effects, including seizures. The present results demonstrated the potential of bemegride as a safe and effective pharmacological activation agent of EDs in anesthetized dogs with epilepsy and provided more options for the diagnosis and therapeutic planning of epilepsy, including presurgical evaluations, in dogs

浦賀水道付近で観測された特異なオキシダント-時間曲線 : 昭和50年7月18日の事例

application/pdfOn July 18, 1976 the east part of Kanagawa Prefecture experienced a heavy photochemical air pollution. A peculiar oxidant-time curve which had two sharp peaks of 0.33 ppm and 0.36 ppm at 10:29 and 11:10 respectively was recorded at the Kamoi Junior High School facing the Straits. Several sources, mobile and stationary, of primary pollutants were investigated. It has been suggested that oxides of nitrogen emitted from many ships passing the Straits could be one of possible causes giving the peculiar curve.departmental bulletin pape

Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA-2

Heir PWMs. Each PFM/PWM represents a human TFBS that has both TE-derived and non-repetitive experimentally characterized sites in the genome. The TFBS are identified with their TRANSFAC matrix identifiers and the official human gene name symbol for the binding transcription factor proteins.<p><b>Copyright information:</b></p><p>Taken from "Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA"</p><p>http://www.biomedcentral.com/1471-2164/9/226</p><p>BMC Genomics 2008;9():226-226.</p><p>Published online 17 May 2008</p><p>PMCID:PMC2397414.</p><p></p

Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA-0

Ted along with the percentages that are expected (dark) based on the background frequencies of the TEs in the genome. All class/family percentages are relative, . they are normalized by the total number of TEs that donate TFBS (observed) and the total number of TEs in the genome (expected) respectively.<p><b>Copyright information:</b></p><p>Taken from "Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA"</p><p>http://www.biomedcentral.com/1471-2164/9/226</p><p>BMC Genomics 2008;9():226-226.</p><p>Published online 17 May 2008</p><p>PMCID:PMC2397414.</p><p></p

Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA-4

Om sequences (green) and matrix-random sequences (blue) for the M00671 matrix representing the TFBS bound by TCF-4 (A) and the M01037 matrix for TFBS bound by GLI1 (C). (B & D) The matrix-random score distributions are compared to the scores for individual TFBS derived from TEs (red) versus the non-repetitive TEs (gray). Data are shown for M00671 TCF-4 (B) and M01037 GLI1 (D).<p><b>Copyright information:</b></p><p>Taken from "Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA"</p><p>http://www.biomedcentral.com/1471-2164/9/226</p><p>BMC Genomics 2008;9():226-226.</p><p>Published online 17 May 2008</p><p>PMCID:PMC2397414.</p><p></p

Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA-3

Ong with the positions of the repetitive DNA elements (black) at that locus. FOSL1 is encoded on the Crick strand of human chromosome 11. An Alu insertion (red) that donates a TCF-4 binding sites is found just upstream of the FOSL1 5' untranslated region in the proximal promoter region. Summary statistics and a sequence alignment between the FOSL1 proximal promoter sequence and the AluJb subfamily consensus sequence are shown with the TFBS location indicated (entire site boxed in red, contact residues highlighted in yellow).<p><b>Copyright information:</b></p><p>Taken from "Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA"</p><p>http://www.biomedcentral.com/1471-2164/9/226</p><p>BMC Genomics 2008;9():226-226.</p><p>Published online 17 May 2008</p><p>PMCID:PMC2397414.</p><p></p

Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA-1

On-repetitive DNA (NR). For each category, conservation levels were determined by averaging across the entire TFBS site (red), the specific contact part of the site that is thought to physically interact with the transcription factor (blue) and the sequence context part of the site that does contact the transcription factor (green).<p><b>Copyright information:</b></p><p>Taken from "Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA"</p><p>http://www.biomedcentral.com/1471-2164/9/226</p><p>BMC Genomics 2008;9():226-226.</p><p>Published online 17 May 2008</p><p>PMCID:PMC2397414.</p><p></p