The Pilgrim's Progress 第二部 : その続編としての意味について

application/pdf英米言語文化研究. 1996, 44, p.37-49departmental bulletin pape

Improved Constraints on D0-D̅0 Mixing in D0→K+π- Decays from the Belle Detector

journal articl

基礎学力重視という原点に戻って考えるべきキャリア教育の進路 ： 米国における職業教育、職業指導・キャリア教育の歴史から学ぶ

2008-05departmental bulletin pape

Introductory mathematical analysis.

Includes index.xvii, 811, [56] p.

大気中水銀の地上への降下・沈着

application/pdfFrom a chlor-alkali plant some amount of mercury vapor is emitted to the atmosphere, Fallout of the mercury from the atmosphere to the ground was investigated by means of a miniature wind tunnel. Deposition velocity of mercury to soil was determined to be 3×10^-4 m/s from the experiment. The amount of the mercury deposited to the ground was then estimated by using a deposition model. The present estimation indicates that less than 9% of the total emission of the mercury was deposited to the ground at wind velocity of 0.5 to 3 m/s in a circular area having a radius of 500 m around the emission source. The estimate was in reasonable agreement with Wallin's results which were deduced from an analysis of moss and snow.departmental bulletin pape

Update on the Keio collection of Escherichia coli single‐gene deletion mutants

The Keio collection (Baba et al, 2006) has been established as a set of single‐gene deletion mutants of Escherichia coli K‐12. These mutants have a precisely designed deletion from the second codon from the seventh to the last codon of each predicted ORF. Further information is available at http://sal.cs.purdue.edu:8097/GB7/index.jsp or http://ecoli.naist.jp/. The distribution is now being handled by the National Institute of Genetics of Japan (http://www.shigen.nig.ac.jp/ecoli/pec/index.jsp). To date more than 4 million samples have been distributed worldwide. As we described earlier (Baba et al, 2006), gene amplification during construction is likely to have led to a small number of mutants with genetic duplications.journal articl

Association between obesity and gene polymorphisms (ADRB3,HTR2A, NOS1)

Obesity is a risk factor for many diseases, including diabetes mellitus, the incidence of which has nearly tripled since 1975, and is known to be caused by dietary and other lifestyle-related diseases as well as genetic factors. In this study, to elucidate the effects of genetic factors on individual differences in obesity vulnerability, I focused on four SNPs, including functional polymorphisms of ADRB3 (rs4994), HTR2A (rs6311, rs6313), and NOS1 (rs2682826), and compared the differences in the frequencies of these polymorphisms between nine obese subjects (BMI ≥ 25) and 51 non-obese subjects (BMI < 25) living in a Japanese prefecture. There was no significant difference in the allelic frequency of each SNP between the obese and non-obese groups. In addition, analysis of the combinations of gene polymorphisms showed that they were not associated with the risk of diabetes. Therefore, ADRB3 (rs4994), HTR2A (rs6311, rs6313), and NOS1 (rs2682826) gene SNPs do not appear to be risk factors for obesity.肥満は糖尿病を含め，多くの疾患を引き起こす危険因子である。1975年以降3倍近い増加の傾向を示しており，発症原因として食生活をはじめとする生活習慣病の他，遺伝的な要因の関与が知られてきた。本研究では，肥満脆弱性の個人差に及ぼす影響を明らかにするために，4つのSNP（ADRB3（rs4994），HTR2A（rs6311およびrs6313），およびNOS1（rs2682826）に着目し，日本人在住の9名の肥満被検者（BMI ≥ 25）と非肥満被検者51名（BMI < 25）の間で多型の頻度の違いを比較した。なお，遺伝子型の判定にはPCR-RFLP法を用いた。解析の結果，各SNPの多型頻度および対立遺伝子頻度は肥満群と対照群の間に有意な差は認められなかった。また，遺伝子多型の組み合わせによる解析においても関連性は認められなかった。したがってHTR2A（rs6311, rs6313），ADRB3（rs4994）およびNOS1（rs2682826）遺伝子多型は肥満を引き起こすリスクファクターである可能性は低いことが示された。journal articl

応力・ひずみ測定技術調査研究分科会報告

rights: 社団法人日本機械学会 rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである relation: IsVersionOf: http://ci.nii.ac.jp/naid/110002470915/textapplication/pdfjournal articl

Supplementary Methods, Figure Legends, Figures S1 - S7 from Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Supplementary Figure S1. CyTOF analysis of biological samples from Ptenpc-/-Smad4pc-/- mice (Related to Figure 2). Supplementary Figure S2. Strategy used for MDSCs Isolation (Related to Figure 3). Supplementary Figure S3. Treatment scheme for Gr-1 antibody, peptibody, and Cxcr2 inhibitor SB225002. Supplementary Figure S4. IHC staining of Ki67, CD45, Vimentin, Smooth muscle actin (SMA) and Trichrome staining of mouse prostate tissues treated with IgG control or Gr1 antibody. Supplementary Figure S5. The top 10 differentially expressed genes in Ptenpc-/-Smad4pc-/- tumors as compared to Ptenpc-/- tumors, identified by microarray analysis (n=5). Figure S6. Top 10 activated oncogenic signatures identified by GSEA analysis in Ptenpc-/- Smad4pc-/- tumors as compared to Ptenpc-/- tumors (n=5). Figure S7. Clustering of primary prostate tumors from Wallace et al into MDSC-high and MDSC-low subtypes.</p

Supplementary Table S7 from Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

The 39-gene signatures curated from literatures.</p