冠動脈バイパス術患者における術前アスピリン投与中止時期の検討

研究科: 千葉大学大学院医学薬学府学位:千大院医薬博甲第医1081号博士(医学)千葉大

“O, How This Mother Swells Up toward My Heart!” ― King Learにおける放浪の諸相 ―

2008-03-31In contrast to Cordella in The True Chronicle Historie of King Leir and His Three Daughters, Cordelia in 4.4 of King Lear appears, deprived of vagrancy, as a warrior who “redeems nature from the general curse” (4.6.202). The question now arises: why does Shakespeare dare to deprive Cordelia of vagrancy? The purpose of this paper is to elucidate some aspects of vagrancy in King Lear, especially putting focus on the relevance between the mobility of female characters and vagrancy in early modern England. The reproof of Goneril who accuses Lear and his knights of their riotousness, strongly reminiscent of aristocrats’ complaints against royal progresses in Elizabethan England, indicates that Lear’s stay at Goneril’s palace plays a variation on an official journey of royalty. Moreover, it seems reasonable to suppose that Lear’s wandering in the wilderness represents the “darker” (1.1.35) side of the royal progress. It is important to note that Lear’s daughters also play the parts of wanderer in the theatrical space: Cordelia is banished from Lear’s court and then, returns as an exile; Both Goneril and Regan free themselves from the fetters of patriarchy and make a temporary “amorous sojourn” (1.1.47) at Gloucester’s house. They are clearly representative of “masterless women” in early modern England, who deserted their husbands or run away from masters. One can safely state that Lear’s cry “O, how this mother swells up toward my heart!” (2.2.246) correctly predicts the mobility of his daughters. The relationship between Edgar and Edmund will offer the clue to finding the reason why the vagrancy of Cordelia has to be eradicated. It is obvious that Edgar, in respect of imitating gestures and voice of “Tom / o’Bedlam” (1.2.135-36), bears a striking resemblance to Edmund. Nevertheless, when Edgar, by casting off vagrancy in 5.3, reveals himself as Gloucester’s legitimate son, he decisively breaks away from Edmund. This is even more true of Cordelia in 4.4, who identifies herself as “one daughter / Who redeems nature from the general curse / Which twain have brought her to” (4.6.201-03).departmental bulletin pape

Studies of CP Violation in B→J/ψK* Decays

journal articl

原油エマルジョンと送油の問題に就いて

東京帝国大学工学部種別:卒業論文thesi

中部山岳以西の亜高山性植生および高山性植生の植物社会学的研究 : その2.植生単位の分布特性

application/pdfapplication/pdfpostprintThe Vaccinio-Piceetea, Betulo-Ranunculetea and Oxycocco-Sphagnetea plant communities are characteristic of the subalpine zone and the boreal zone. The Caricirupestris-Kobresietea bellardii, Cetrario-Leuseleurietea and Phyllodoco-Harrimanelletea plant communities are characteristic of the alpine zone and the arctic zone. Some alpine vegetation occurs in the subalpine zone due to edaphic and microclimatic factors. The subalpine vegetation almost reaches the top of the mountains in Chubu about 3,000 M above sea level. There is no clearly alpine zone in this area. The small alpine area, which is meadow or desert, we find above a subalpine area composed of dwarf Pinus pumila mosaic. Three different areas are recognized by plant community distribution in the research area; (ⅰ) Chubu-mountain-pacific-area, (ⅱ) Chubu-mountain-Japan Sea-area and (ⅲ) Shikoku-Kii-area. In the light of plant geographical literature global distribution areas of the recognized species in the Northern hemisphere are discussed from the systematical and synchorological points of view. The subalpine flora is characterized by Japanese endemic species and Asian species often with endemic varieties. The alpine flora it is characterized by species of the circumpolar region, endemic varieties are also frequent here.Contributions from the Department of Vegetation Science, Institute of Environmental Science & Technology, Yokohama Natlonal University No.197departmental bulletin pape

Dynamic Correlation between Pressure-Induced Protein Structural Transition and Water Penetration

Water penetration into the hydrophobic interior of proteins has been postulated to be a primary force driving pressure-induced denaturation of proteins. The water penetration model is supported by several theoretical and simulation studies, although its direct evidence is lacking. In this study, 1 μs all-atom molecular dynamics simulations of ubiquitin in explicit water at high and low pressures are performed to examine the water penetration model. The high-pressure simulation starts from a crystal structure at atmospheric pressure and successfully reproduces the main characteristics of a high-pressure structure obtained by NMR. Water penetrates into a specific hydrophobic core of the protein and is ejected from the interior several times. The structural transition results from the relative stabilization of a preexisting metastable structure by applying pressure. A time correlation analysis demonstrates that the transition is accompanied by the penetration of water within a time scale comparable to the relaxation time of water itself. Simultaneous water penetration only occurs above a certain high pressure

0812-9869-9940 (WA), Jual Keranda Mayat Sawal

<p>0812-9869-9940 (WA), Jual Keranda Mayat Sawal@@Jual Keranda Mayat Sawal, Jual Keranda Mayat Mekarlaksana, Jual Keranda Mayat Telukawur, Jual Keranda Mayat Brantaksekarjati, Jual Keranda Mayat Bugo, Jual Keranda Mayat Gidangelo, Jual Keranda Mayat Guwosobokerto, Jual Keranda Mayat Kedungsarimulyo, Jual Keranda Mayat Kendengsidialit@@keranda jenazah 1 set promo @keranda mayat dan pemandian sepaket@keranda awet kokoh anti karat@paket keranda murah@paket keranda jenazah dan pemandian 1 paket@keranda paket@paket pemandian jenazah dan keranda@pemandian jenazah@GRATIS KAIN PENUTUP KERANDA@Menyediakan berbagai kebutuhan kepengurusan jenazah@@Dengan material stainless steel, kami memproduksi KERANDA JENAZAH dan PEMANDIAN JENAZAH yang mana ANTI KARAT, KOKOH, dan JELAS KEAWETANNYA.@@Memudahkan bagi jamaah sekalian dalam kepengurusan jenazah@Dibuat dari STAINLESS STEEL sehingga tahan karat dan aman disimpan dalam ruangan@Desain yang KOKOH mampu menahan berat hingga 300kg @@Spesifikasi Singkat:@-KERANDA@Bahan : Stainless Steel 201@Dimensi : Panjang 200 cm � Lebar 65 cm -Tinggi kurungan 64cm@Beban Maximum 300 kg@@-PEMANDIAN JENAZAH@Bahan : Stainless Steel 201@Dimensi : Panjang 205cm - Lebar 75cm - Tinggi 80cm@Beban MAX : 300KG@@@#JualKerandaMayatSawal, #JualKerandaMayatMekarlaksana, #JualKerandaMayatTelukawur, #JualKerandaMayatBrantaksekarjati, #JualKerandaMayatBugo, #JualKerandaMayatGidangelo, #JualKerandaMayatGuwosobokerto, #JualKerandaMayatKedungsarimulyo, #JualKerandaMayatKendengsidialit</p&gt

Water Molecules in a Protein Cavity Detected by a Statistical−Mechanical Theory

Four water molecules confined in a small cavity of hen egg-white lysozyme were detected by means of the three-dimensional (3D) RISM theory, a statistical−mechanical theory of molecular solutions. This is the first theoretical realization of confined molecules in a protein without making nonsense tricks, such as placing the molecules in the space a priori. Possible impacts which the result may have on biochemistry and biophysics, including the molecular recognition, enzymatic reactions, etc., are discussed

Selective Ion-Binding by Protein Probed with the 3D-RISM Theory

Cations (Ca2+, Na+, K+) selectively bound by human lysozyme and its mutants are probed by the 3D-RISM theory, a statistical mechanics theory of liquids

Ligand Mapping on Protein Surfaces by the 3D-RISM Theory: Toward Computational Fragment-Based Drug Design

In line with the recent development of fragment-based drug design, a new computational method for mapping of small ligand molecules on protein surfaces is proposed. The method uses three-dimensional (3D) spatial distribution functions of the atomic sites of the ligand calculated using the molecular theory of solvation, known as the 3D reference interaction site model (3D-RISM) theory, to identify the most probable binding modes of ligand molecules. The 3D-RISM-based method is applied to the binding of several small organic molecules to thermolysin, in order to show its efficiency and accuracy in detecting binding sites. The results demonstrate that our method can reproduce the major binding modes found by X-ray crystallographic studies with sufficient precision. Moreover, the method can successfully identify some binding modes associated with a known inhibitor, which could not be detected by X-ray analysis. The dependence of ligand-binding modes on the ligand concentration, which essentially cannot be treated with other existing computational methods, is also investigated. The results indicate that some binding modes are readily affected by the ligand concentration, whereas others are not significantly altered. In the former case, it is the subtle balance in the binding affinity between the ligand and water that determines the dominant ligand-binding mode