鉄酸化細菌を利用したウランの酸化還元と分離プロセスへのその応用

科学研究費補助金 研究種目：基盤研究(B)(2)　課題番号：16360472　研究代表者：山本一良　研究期間：2004-2005年度research repor

玉砂利を使用したオープンケーソンに作用する周面摩擦に関する研究 <平成12年度 共同研究の概要>

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Search for D0-D̅0 Mixing in D0→K+π- Decays and Measurement of the Doubly-Cabibbo-Suppressed Decay Rate

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AGAMOUS イデンシ ノ ハナ メリステム ゾウショク ヨクセイ ト ハナビラ サイズ ニオケル ヤクワリ ノ カイセキ

奈良先端科学技術大学院大学博士(バイオサイエンス)doctoral thesi

The Relationship between Poverty and Hookworm Prevalence

<p>(Illustration: Margaret Shear, Public Library of Science, adapted from [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020067#pmed-0020067-b4" target="_blank">4</a>])</p

Scheme for the Development and Quality-Control Testing of the <i>Na</i>-ASP-2 Hookworm Vaccine, and Its Transition from the Laboratory into the Clinic

<p>After the selection of ASP-2 from N. americanus (<i>Na</i>-ASP-2) as the lead candidate antigen based on a series of research and development (R&D) tests—which included immunoepidemiology studies identifying human correlates of immunity to hookworm and confirmatory laboratory animal vaccine trials—the recombinant antigen was expressed in yeast and then developed as a biologic through a well-defined product development strategy (PDS). By following the product development strategy, process development (PD) and manufacturing led to the generation of pilot batches at different scales prior to technology transfer to a cGMP manufacturing facility. Both process development and manufacturing rely on developing assays for the product's identity, color and appearance, purity, immunological recognition, and potency, as well as qualification of the assays for sensitivity, specificity, accuracy, and reproducibility. Each of these processes must maintain a high level of quality control by following a set of policies, protocols, and standard operating procedures. After the manufacturing of a cGMP product and the required pre-clinical animal testing, a clinical development plan (CDP) was generated. Because the <i>Na</i>-ASP-2 Hookworm Vaccine is a product destined for the world's poorest, it is being developed almost exclusively in the non-profit sector, along with government manufacturers in middle-income countries.</p

Life Cycle of the Human Hookworm N. americanus

<p>The BZA anthelminthics albendazole and mebendazole remove adult hookworms from the gastrointestinal tract. In contrast, the <i>Na</i>-ASP-2 Hoookworm Vaccine is designed to target third-stage infective larvae (filariform larvae). Humoral immunity to the vaccine inhibits the entry of larvae into the gastrointestinal tract and thereby prevents their development into blood-feeding adult parasites. (Illustration: Sapna Khandwala, Public Library of Science, adapted from [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020067#pmed-0020067-b3" target="_blank">3</a>] and [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020067#pmed-0020067-b33" target="_blank">33</a>])</p

Global Distribution of Human Hookworm Infection

<p>(Illustration: Margaret Shear, Public Library of Science, adapted from [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020067#pmed-0020067-b4" target="_blank">4</a>])</p