First-principles calculations of Cu adsorption on an H-terminated Si surface

In this study, we use first-principles simulations to study the adsorption of copper onto H-terminated and partially OH-terminated silicon surfaces. We show that, in contrast to previous studies, copper adsorbs strongly to the H-terminated silicon surface and that the adsorption energy is significantly dependent on the localbonding environment. The addition of a hydroxide group increases the average adsorption energy while reducing the range of adsorption energies due to the strong interaction between copper and oxygen. Our results predict that copper will generally prefer to adsorb at dihydride sites on the surface, agreeing with experimentalstudies of copper nucleation. The adsorption energy hierarchy predicted by the calculations strongly supports the suggestion that copper acts as a micromask in wet chemical etching, blocking reactive sites.journal articl

素子構造材料最適化に関する研究 <平成12年度 受託研究の概要>

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Search for D0-D̅0 Mixing in D0→K+π- Decays and Measurement of the Doubly-Cabibbo-Suppressed Decay Rate

journal articl

ハタケシメジ熱水抽出物の安全性評価

application/pdfAn extract of Hatakeshimeji (Lyophyllum decastes Sing.) was orally administrated once to male and female mice and to male mice for 20 weeks. We macroscopically observed general symptoms, the presence or absence of death during a dose period, and the presence or absence of abnormality upon completion. Results suggest that the general observation of symptoms and increase of weight were unchanged and no death or abnormal findings were present at autopsy.In addition, the extract of Hatakeshimeji (2.88g) was administrated orally to 11 adults for two weeks during which we assessed its safety by conducting blood tests, urine tests, and blood pressure and body measurement checks. Consequently, there were no clinical problems observed with regard to blood test results, hepatic and renal functions, glucose and lipid metabolisms, and blood pressure. Likewise, analysis of agaritine from hot-water extracts of Hatakeshimeji showed no such problems. These results suggest that the extract of Hatakeshimeji is a safe food and may perform some health functions.ハタケシメジ抽出エキスをマウスに単回経口投与もしくは20週間継続的に摂取し，投与期間中の一般症状と死亡の有無を観察するとともに，観察終了日に病理解剖を行い，異常の有無を肉眼的に観察した．その結果，ハタケシメジ抽出エキス投与群では，対照群と同様，一般症状，体重増加推移に変化はなく，異常な剖検所見や死亡は観察されなかった．さらに，ハタケシメジ熱水抽出エキスを成人1日あたり2.88g, 2週間摂取し，血液検査，尿検査，血圧・身体測定および問診から安全性について検討した結果，血液学検査，肝機能，腎機能，糖代謝，脂質代謝，血圧および身体検査の各試験項目において，臨床上問題となる異常所見の発現は一切認められなかった．また，アガリチンについて，ハタケシメジ熱水抽出エキスに含まれるか否かを分析した結果，検出限界2ngで検出されなかった．以上の結果，ハタケシメジ抽出エキスは，安全性の高い食品であり，生活習慣病の1次予防の手段としてハタケシメジの利用が期待される．journal articl

Surrounding Gastric Mucosa Findings Facilitate Diagnosis of Gastric Neoplasm as Gastric Adenoma or Early Gastric Cancer

Background and Aim. It is difficult to master the skill of discriminating gastric adenoma from early gastric cancer by conventional endoscopy or magnifying endoscopy combined with narrow-band imaging, because the colors and morphologies of these neoplasms are occasionally similar. We focused on the surrounding gastric mucosa findings in order to determine how to discriminate between early gastric cancer and gastric adenoma by analyzing the characteristics of the gastric background mucosa. Methods. We retrospectively examined 146 patients who underwent endoscopic submucosal dissection for gastric neoplasm between October 2009 and January 2015. The boundary of atrophic gastritis was classified endoscopically according to the Kimura-Takemoto classification system. Of 146 lesions, 63 early gastric cancers and 21 gastric adenomas were ultimately evaluated and assessed. Results. Almost all gastric adenomas were accompanied by open-type gastritis, whereas 47 and 16 early gastric cancers were accompanied by open-type and closed-type gastritis, respectively (p = 0.037). Conclusions. The evaluation of the boundary of atrophic gastritis associated with gastric neoplasms appears to be useful for discrimination between early gastric cancer and gastric adenoma. When gastric neoplasm is present in the context of surrounding localized gastric atrophy, gastric cancer is probable but not certain.Citation: Miike T, Yamamoto S, Miyata Y, Hirata T, Noda Y, Noda T, Suzuki S, Takeda S, Natsuda S, Sakaguchi M, Maemura K, Hashimoto K, Yamaji T, Abe H, Iwakiri H, Tahara Y, Hasuike S, Nagata K, Kitanaka A, Shimoda K. Surrounding Gastric Mucosa Findings Facilitate Diagnosis of Gastric Neoplasm as Gastric Adenoma or Early Gastric Cancer. Gastroenterol Res Pract. 2016;2016:6527653. doi: 10.1155/2016/6527653. Epub 2015 Dec 24. PMID: 26858751; PMCID: PMC4706934