Search for a stochastic background of 100-MHz gravitational waves with laser interferometers

This letter reports the results of a search for a stochastic background of gravitational waves (GW) at 100 MHz by laser interferometry. We have developed a GW detector, which is a pair of 75-cm baseline synchronous recycling (resonant recycling) interferometers. Each interferometer has a strain sensitivity of ~ 10^{-16} Hz^{-1/2} at 100 MHz. By cross-correlating the outputs of the two interferometers within 1000 seconds, we found h_{100}^2 Omega_{gw} < 6 times 10^{25} to be an upper limit on the energy density spectrum of the GW background in a 2-kHz bandwidth around 100 MHz, where a flat spectrum is assumed.Comment: Accepted by Phys.Rev.Lett.; 10 pages, 4 figure

Search for a Stochastic Background of 100-MHz GravitationalWaves with Laser Interferometers

This Letter reports the results of a search for a stochastic background of gravitational waves (GW) at 100 MHz by laser interferometry. We have developed a GW detector, which is a pair of 75-cm baseline synchronous recycling (resonant recycling) interferometers. Each interferometer has a strain sensitivity of ～10^{-16} Hz^{-1/2} at 100 MHz. By cross-correlating the outputs of the two interferometers within 1000 seconds, we found h^2 100Ω_gw < 6 ×10^25 to be an upper limit on the energy density spectrum of the GW background in a 2-kHz bandwidth around 100 MHz, where a flat spectrum is assumed.journal articl

鰓弓神経節の形成に異常を示す変異体nepの原因遺伝子クローニング

In vertebrates, epibranchial ganglia, consisted of facial, glossopharyngeal and vagal ganglia, have pivotal roles for maintenance of inner envir.onment by transmitting somatosensory stimuli and monitoring of beat rate of the heart and so on. In our past study, we have identified two lines of mutant affected in formation of epibranchial ganglia in zebrafish. One of them, named non-epibranchial (nep), lacks all epibranchial ganglia at two days after fertilization with earlier molecular markers relatively normal, suggesting that disrupted gene in this mutant is required for later differentiation or maintenance of the epibranchial ganglia. To identify it, we positioned nep gene on the linkage group 20 and fond some genetically related genes around nep locus. Based on these observations, we are now trying to clone nep gene.textapplication/pdfdepartmental bulletin pape

Study of Time-Dependent CP Violation in B0→J/ψπ0 Decays

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地域の図書館ネットワークと大学図書館

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Gait design and experimental validation of a snake robot on a pipe with branches using spiral stairs function

This paper presents the gait design and experimental validation of a snake robot on a pipe with branches. The target posture of the robot is designed as a continuous curve, and the robot moves by changing the shape of the curve and the area that it approximates. In addition, the paper presents a novel target shape for a snake robot when moving on a pipe with branches. In the proposed gait, the robot does not contact the pipe with its entire body, and a part of its body is lifted away from the pipe. The contact points between the robot and the pipe move freely using the shifting and rolling motions. The robot surpasses the branches of the pipe by switching the contact points between itself and the pipe. The effectiveness of the proposed gait was demonstrated by simulations using a physics simulator and experiments with an actual robot.journal articl

藤沢市の植生 : 都市環境保全に対する植物社会学的基礎研究

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Cytochrome c polymerization by successive domain swapping at the C-terminal helix

Cytochrome c (cyt c) is a stable protein that functions in a monomeric state as an electron donor for cytochrome c oxidase. It is also released to the cytosol when permeabilization of the mitochondrial outer membrane occurs at the early stage of apoptosis. For nearly half a century, it has been known that cyt c forms polymers, but the polymerization mechanism remains unknown. We found that cyt c forms polymers by successive domain swapping, where the C-terminal helix is displaced from its original position in the monomer and Met-heme coordination is perturbed significantly. In the crystal structures of dimeric and trimeric cyt c, the C-terminal helices are replaced by the corresponding domain of other cyt c molecules and Met80 is dissociated from the heme. The solution structures of dimeric, trimeric, and tetrameric cyt c were linear based on small-angle X-ray scattering measurements, where the trimeric linear structure shifted toward the cyclic structure by addition of PEG and (NH4)2HPO4. The absorption and CD spectra of high-order oligomers (~40 mer) were similar to those of dimeric and trimeric cyt c but different from those of monomeric cyt c. For dimeric, trimeric, and tetrameric cyt c, the ΔH of the oligomer dissociation to monomers was estimated to be about -20 kcal/mol per protomer unit, where Met-heme coordination appears to contribute largely to ΔH. The present results suggest that cyt c polymerization occurs by successive domain swapping, which may be a common mechanism of protein polymerization.journal articl

Immunogenicity of the MSP3-LSP in Volunteers Receiving the Vaccine Adjuvated by Montanide or Alum

<div><p>(A) Scheme of immunisation (arrows) and of sampling (plain circles). Samples for immunoassays were taken 1 mo after each immunisation.</p> <p>(B) Lymphoproliferative responses (bars) and IFN-γ secretion (*), ± SD, as compared to controls. PHA, phytohemagglutinin; TT, tetanus toxoid. IFN-γ values for TT and PHA are those obtained using month 5 samples.</p> <p>(C) Mean ELISA IgG titres to the MSP3-LSP at various time points during and after immunisation (months 1, 5, and 12 after the first immunisation).</p> <p>(D) Proportion of WB-positive individuals in each group at different time points ± 95% confidence intervals.</p> <p>(E) Isotype distribution of antibodies measured in ELISA with IgG subclass-specific secondary antibodies (data from samples collected at month 5).</p> <p>In each graph, the increasing grey colour corresponds to increasing immunisation doses, e.g., for Montanide (unhatched bars) from left to right, 10–10–10, 20–20–20, 30–30–10, 100–10–10, and for alum (hatched bars) 30–30–30 and 100–10–10.</p></div

In Vitro Antiparasitic Effect of the Volunteers' Antibodies in ADCI Assay

<p>Shown are results obtained with volunteers' serum samples collected either at month 5 (A) or at month 12 (B), as compared to the African immune IgG pool able to transfer clinical protection in humans (dark bars, pool of immune African globulin-positive control). Each bar represents the mean value obtained with each volunteer serum, in three separate experiments ± SD. The results from WB assays (performed with months 5 and 12 samples side by side with a positive control) are shown below those of the ADCI assay for each individual volunteer and are expressed as either negative (−) or positive (+ or ++). For each group, the increasing grey colour corresponds to increasing immunisation doses, e.g., from left to right, Montanide (unhatched bars) 10–10–10, 20–20–20, 30–30–10, and 100–10–10, and for alum (hatched bars) 30–30–30 and 100–10–10. SGI values 30% or greater are considered positive. Dotted line indicates the threshold of positivity of the ADCI assay.</p