まえがき

othe

Crystal Structure and Stoichiometric Composition of Potassium-Intercalated Tetracene

application/pdfInorganic Chemistry. 2020, 59 (17), P.12545-12551journal articl

Search for \bar{B}^0 →Λ_c^+\bar{Λ}_c^- decay at Belle

We search for the doubly charmed baryonic decay \bar{B}^0 →Λ_c^+\bar{Λ}_c^-, in a data sample of 520×106 B\bar{B} events accumulated at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider. We find no significant signal and set an upper limit of B(\bar{B}^0 →Λ_c^+\bar{Λ}_c^-)< 6.2×10^{-5} at 90% confidence level. The result is significantly below a naive extrapolation from B(B^-→　Ξ\begin0\c\end\bar{Λ}_c^-) assuming a simple Cabibbo-suppression factor of |V_cd/V_cs|^2. The small branching fraction may be attributed to a suppression due to the large momentum of the baryonic decay products, which has been observed in other charmed baryonic two-body B decays.journal articl

Evidence for Direct CP Violation in B0→K+π-Decays

journal articl

Natural gas transmission and processing

Includes bibliographical references and index.xxxi, 636 p. :Handbook of Natural Gas Transmission and Processing gives engineers and managers complete coverage of natural gas transmission and processing in the most rapidly growing sector to the petroleum industry. The authors provide a unique discussion of new technologies that are energy efficient and environmentally appealing at the same time. It is an invaluable reference on natural gas engineering and the latest techniques for all engineers and managers moving to natural gas processing as well as those currently working on natural gas projects. * Provides practicing engineers critical information on all aspects of gas gathering, processing and transmission * First book that treats multiphase flow transmission in great detail * Examines natural gas energy costs and pricing with the aim of delivering on the goals of efficiency, quality and profi

Schematic diagram of the key features of the global cDNA amplification method

<p><b>Copyright information:</b></p><p>Taken from "An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis"</p><p>Nucleic Acids Research 2006;34(5):e42-e42.</p><p>Published online 17 Mar 2006</p><p>PMCID:PMC1409679.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> () Evaluation system to verify representation of amplified cDNA from diluted ES cellular RNA by Q-PCR and/or microarray. () Gene representation distorted during the global PCR. Diluted ES cellular RNA (10 pg) was amplified as described elsewhere (), and the replicates of amplification were sequentially sampled at 16, 20, 24, 28, 32, 36, 40 and 44 cycles. The expression levels of , , , , and were measured by Q-PCR, normalized by that of , and represented with brown, cyan, yellow, blue, pink and green lines, respectively. The averages of four independent experiments are plotted. () Schematic diagram of cDNA amplification. The mRNA and cDNA are colored pink and orange, respectively. The V1, V3 and T7 promoter sequences are represented by blue, red and green boxes, respectively. The bars above the letters represent the complementary sequences

Direct application of the newly developed method to single ICM cells from mouse E3

<p><b>Copyright information:</b></p><p>Taken from "An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis"</p><p>Nucleic Acids Research 2006;34(5):e42-e42.</p><p>Published online 17 Mar 2006</p><p>PMCID:PMC1409679.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p>5 blastocyst reveals the presence of two distinct cell populations. () Hierarchical clustering of single ICM cells. () Heat map representation of differentially expressed genes (top 100). The expression levels are color-coded from red (high) to blue (low). The expression levels are normalized in the lows. () The correlation of gene expression is preserved between E3.5 and E4.5. The copy numbers of expressed genes were estimated with Q-PCR. Orange, pink and green bars represent high, middle and low/non-detectable expression of , respectively. -values of the Chi-square test for independence from expression are indicated. (D and F) Blastocysts at E3.5 () and E4.5 (). The typical embryos used for single-cell experiments are shown. (E and G) Expression levels of key genes related to PE and epiblast at E3.5 () and E4.5 (). All of the single-cell samples of ICMs are shown. The representation code is the same as in (C)

Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer

Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms. In this study, we assessed the feasibility of using DNA methylation detected in bowel lavage fluid (BLF) for colorectal cancer screening. A total of 508 BLF specimens were collected from patients with colorectal cancer (n = 56), advanced adenoma (n = 53), minor polyp (n = 209), and healthy individuals (n = 190) undergoing colonoscopy. Methylation of 15 genes (miR-1-1, miR-9-1, miR-9-3, miR-34b/c, miR-124-1, miR-124-2, miR-124-3, miR-137, SFRP1, SFRP2, APC, DKK2, WIF1, LOC386758, and ZNF582) was then analyzed in MethyLight assays, after which receiver operating characteristic (ROC) curves were analyzed to assess the diagnostic performance of BLF methylation. Through analyzing BLF specimens in a training set (n = 345), we selected the three genes showing the greatest sensitivity for colorectal cancer detection (miR-124-3, 71.8%; LOC386758, 79.5%; and SFRP1, 74.4%). A scoring system based on the methylation of those three genes (M-score) achieved 82% sensitivity and 79% specificity, and the area under the ROC curve (AUC) was 0.834. The strong performance of this system was then validated in an independent test set (n = 153; AUC = 0.808). No significant correlation was found between M-score and the clinicopathologic features of the colorectal cancers. Our results demonstrate that DNA methylation in BLF specimens may be a useful biomarker for the detection of colorectal cancer.Citation: Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tsuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H. Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer. Cancer Prev Res (Phila). 2014 Oct;7(10):1002-10. doi: 10.1158/1940-6207.CAPR-14-0162. Epub 2014 Aug 19. PMID: 25139296