人間-機械協調系としての新しい実用遠隔操作システムの構築に関する研究 -システムの受動性を考慮したテレマニピュレ-タのTask-oriented制御法

名古屋大学Nagoya University博士(工学)名古屋大学博士学位論文 学位の種類:博士(工学) (論文) 学位授与年月日:平成11年4月30日doctoral thesi

経済分析メジャーへの招待 : あなたにとって経済学とは何ですか？《特集寄稿》

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Upper Bound on the Decay τ→μγ from the Belle Detector

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A THEORY OF DIFFERENTIAL EQUATIONS VIEWED THROUGH GROUP PARAMETER EXTENSIONS. II. A METHOD OF SOLUTION OF LINEAR PARTIAL DIFFERENTIAL EQUATIONS OF THE SECOND ORDER WITH FUNCTION COEFFICIENTS.

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Determination Of Apparent Wave Propagation Velocity From Damage Statics Of Buried Pipelines

A method of determining the apparent wave propagation velocity of seismic waves with respect to the ground surface is presented. The intent is to establish a practical procedure to deal with the effects of earthquakes on long structures such as bridges and pipelines as well as on the torsional rotation of foundations of symmetric buildings. This method utilizes the connection between knowledge of the seismic behavior of buried pipelines and a probabilistic description of spatial variation of strong earthquake ground displacements. The pipeline is assumed to be a straight slender beam on a flexible foundation, and the ground displacement is interpreted as a random function of space variables. This model, together with the recently reported damage statistics, makes it possible to identify an average apparent wave propagation velocity. The resulting velocity is a function of the predominant period of the ground movement in question. A comparison of the analytical and observed apparent wave propagation velocities indicates a potential validity of the probabilistic method presented in this paper

Additional file 2: Table S2. of LIN7A is a major determinant of cell-polarity defects in breast carcinomas

List of specific deregulated genes in invasive micropapillary carcinoma (IMPC) (Student t test, p-value ≤0.05, fold-change ≥1.5). (PDF 253 kb

Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice

Significance: Intrinsic optical signals (IOS) generated in the cortical tissue as a result of various interacting metabolic processes are used extensively to elucidate the underlying mechanisms that govern neurovascular coupling. However, current IOS measurements still often rely on bulky, tabletop imaging systems, and there remains a dearth of studies in freely moving subjects. Lightweight, miniature head-mounted imaging devices provide unique opportunities for investigating cortical dynamics in small animals under a variety of naturalistic behavioral settings.Aim: The aim of this work was to monitor IOS in the somatosensory cortex of wild-type mice by developing a lightweight, biocompatible imaging device that readily lends itself to animal experiments in freely moving conditions.Approach: Herein we describe a method for realizing long-term IOS imaging in mice using a 0.54-g, compact, CMOS-based, head-mounted imager. The two-part module, consisting of a tethered sensor plate and a base plate, allows facile assembly prior to imaging sessions and disassembly when the sensor is not in use. LEDs integrated into the device were chosen to illuminate the cortical mantle at two different wavelengths in the visible regime (λcenter: 535 and 625 nm) for monitoring volume- and oxygenation state-dependent changes in the IOS, respectively. To test whether the system can detect robust cortical responses, we recorded sensory-evoked IOS from mechanical stimulation of the hindlimbs (HL) of anesthetized mice in both acute and long-term implantation conditions.Results: Cortical IOS recordings in the primary somatosensory cortex hindlimb receptive field (S1HL) of anesthetized mice under green and red LED illumination revealed robust, multiphasic profiles that were time-locked to the mechanical stimulation of the contralateral plantar hindpaw. Similar intrinsic signal profiles observed in S1HL at 40 days postimplantation demonstrated the viability of the approach for long-term imaging. Immunohistochemical analysis showed that the brain tissue did not exhibit appreciable immune response due to the device implantation and operation. A proof-of-principle imaging session in a freely behaving mouse showed minimal locomotor impediment for the animal and also enabled estimation of blood flow speed.Conclusions: We demonstrate the utility of a miniature cortical imaging device for monitoring IOS and related hemodynamic processes in both anesthetized and freely moving mice, cueing potential for applications to some neuroscientific studies of sensation and naturalistic behavior.journal articl

Additional file 2: Table S2. of LIN7A is a major determinant of cell-polarity defects in breast carcinomas

List of specific deregulated genes in invasive micropapillary carcinoma (IMPC) (Student t test, p-value ≤0.05, fold-change ≥1.5). (PDF 253 kb

Receiving Operating Curve (ROC) curve for the number of breakpoints threshold determination.

<p>Intersection of dotted-lines = Youden index.</p

Flowshart of patients and tumor’s selection and design of the study.

<p>Flowshart of patients and tumor’s selection and design of the study.</p