Upper Bound on the Decay τ→μγ from the Belle Detector

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THEORY OF A BANACH SPACE WITH SEMI-NORMS

application/pdfdepartmental bulletin pape

処遇に対する公正感（下）－処遇制度の設計・運用における条件と阻害要因

2009-03According to the existing HRM (human resource management) studies, labors regard their rewards as unfair when the compensation policies originally manifested haven't been emerged (unanticipated consequences). But, social-psychological and sociological perspectives suggest that labors' perception of fairness or unfairness is not always determined by compensation principle and actual compensation. So, even betrayed labors can positively accept undesirable rewards. The relationship between compensation and labors' perception about compensation is various depending on the labors' attitude about compensation. If labors are satisfied with their working life totally, they may not to care a gap between a principle and actual conditions of the compensation. Labors' attitude is various, not only in respect of their ideal about compensation, but also in respect of their intensity of concern about compensation. Future research must specify that factors constructing labors' attitude are ubiquitous within and outside the reward-related experiences.departmental bulletin pape

Summarized PT/LR Clinical and histological features.

<p><b>Cor</b> (Correspondence): correspondence number with the Bollet/Servant cohort from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103986#pone.0103986-Bollet1" target="_blank">[16]</a>, <b>Type</b>: histological type of the tumor (D =  ductal, L =  lobular), <b>Grade</b>: Aggressiveness of the tumor (1 to 3), <b>ER</b>: presence of estrogen receptors, <b>PR</b>: presence of progesterone receptors, <b>HER2</b>: presence of HER2 receptors, <b>Loc</b> (Location): 1 if the recurrence was located less than 4cm from the PT.</p

Histogram of the distribution of methylome-similarity score (MS) between unrelated PT/LR pairs.

<p>MS score for matched pairs is represented by circles. The vertical dashed line corresponds to the 95% quantile of the distribution of the MS scores for the unrelated pairs, used as a threshold to define clonal pairs ().</p

Comparison of classification methods for clonality between pairs in the PT/LR cohort.

<p><b>Cor</b> (Correspondence): correspondence number with the Bollet/Servant cohort. <b>scores</b>: scores obtained with partial identity (PIS) or methylation (MS). <b>Time</b>: time elapsed between diagnosis of the PT and diagnosis of the recurrence. <b>Classification</b>: classification of the recurrence based on copy number (PIS), methylation (MS) or clinical features (clinical). <b>Divergence</b>: which method deviated from the others.</p

Correlation between methylation and copy-number scores.

<p>The horizontal red line (resp. vertical dashed blue line) corresponds to the 95% quantile of the distribution of the methylation-scores (resp. partial identity scores) for the unrelated pairs: (resp. ). PT/AM (resp. PT/LR, resp. PT/CL) pairs are colored in yellow (resp. blue, resp. pink). The black line corresponds to the linear regression between methylation and copy-number scores for all the datasets.</p

Prognostic Impact of Time to Ipsilateral Breast Tumor Recurrence after Breast Conserving Surgery

<div><p>Background</p><p>The poor prognosis of patients who experience ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) is established. A short time between primary cancer and IBTR is a prognostic factor but no clinically relevant threshold was determined. Classification of IBTR may help tailor treatment strategies.</p><p>Purpose</p><p>We determined a specific time frame, which differentiates IBTR into early and late recurrence, and identified prognostic factors for patients with IBTR at time of the recurrence.</p><p>Methods</p><p>We analyzed 2209 patients with IBTR after BCS. We applied the optimal cut-points method for survival data to determine the cut-off times to IBTR. A subgroup analysis was performed by hormone receptor (HR) status. Survival analyses were performed using a Cox proportional hazard model to determine clinical features associated with distant-disease-free survival (DDFS) after IBTR. We therefor built decision trees.</p><p>Results</p><p>On the 828 metastatic events observed, the majority occurred within the first 3 months after IBTR: 157 in the HR positive group, 98 in the HR negative group. We found different prognostic times to IBTR: 49 months in the HR positive group, 33 in the HR negative group. After multivariate analysis, time to IBTR was the first discriminant prognostic factor in both groups (HR 0.65 CI95% [0.54–0.79] and 0.42 [0.30–0.57] respectively). The other following variables were significantly correlated with the DDFS: the initial number of positive lymph nodes for both groups, the initial tumor size and grade for HR positive tumors.</p><p>Conclusion</p><p>A short interval time to IBTR is the strongest factor of poor prognosis and reflects occult distant disease. It would appear that prognosis after IBTR depends more on clinical and histological parameters than on surgical treatment. A prospective trial in a low-risk group of patients to validate the safety of salvage BCS instead of mastectomy in IBTR is needed.</p></div

Summarized PT/CL Clinical and histological features.

<p><b>Type</b>: histological type of the tumor (D =  ductal, L =  lobular, Med = Medullary, Meta = Metaplasic), <b>Grade</b>: Aggressiveness of the tumor (1 to 3), <b>ER</b>: presence of estrogen receptors, <b>PR</b>: presence of progesterone receptors, <b>HER2</b>: presence of HER2 receptors.</p

Accuracy of multivariate analysis with respect to feature selection to classify primary tumors from locoregional evolutions.

<p>Accuracy to classify PT from AM (resp. LR, resp. CL.) is represented in yellow (resp. blue, resp. pink).</p