A geometric representation of the generalized mean curvature

学位記号番号 : 博理工甲第1088号博士の専攻分野の名称 : 博士(理学) 学位授与年月日 : 平成30年3月23日textapplication/pdfthesi

The environment of lawn planting in the elementary school ground changes children’s playing

departmental bulletin pape

Upper Bound on the Decay τ→μγ from the Belle Detector

journal articl

SOME NOTES ON THE QUEUES WITH MULTIPLE INPUTS

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SITE Amplification Characteristics In Miyazaki Prefecture, Japan Using Microtremor And Seismic Records

The seismic records from 52 stations of the seismic network deployed in Miyazaki Prefecture, Japan, arecurrently used to grasp the distribution of seismic intensity of the prefecture immediately after the occurrence of an earthquake. However, the number of instruments may not be large enough to capture the detailed intensity distribution. Hence, microtremor measurements were conducted to estimate site response characteristics of the seismic stations and other locations. The horizontal-to-vertical （H/V） Fourier spectral ratios were calculated for seismic records and microtremor. In some stations having geological survey data, the transfer functions for S-wave and H/V amplitude ratio of Rayleigh wave were also calculated. Comparing all these functions, possibility is suggested that the H/V spectral ratio of microtremor can be used as a quasi-transfer function to predict the seismic motion at the location without instruments

Supplementary Data from Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

Supplementary Data from Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesion

Two Perspectives on this Article from Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model

Two Perspectives on this Article from Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Mode

Ultrasensitive Electrochemical Immunosensor for Oral Cancer Biomarker IL-6 Using Carbon Nanotube Forest Electrodes and Multilabel Amplification

Squamous cell carcinomas of head and neck (HNSCC) are associated with immune, inflammatory, and angiogenic responses involving interleukin-6 (IL-6). This article reports an ultrasensitive electrochemical immunosensor for human IL-6 and proof-of-concept studies of IL-6 detection in HNSCC cells. Single wall carbon nanotube (SWNT) forests with attached capture antibodies (Ab1) for IL-6 were used in an electrochemical sandwich immunoassay protocol using enzyme label horseradish peroxidase (HRP) to measure very low (≤30 pg mL−1) and elevated levels of IL-6. Two levels of multienzyme labeling were used to measure a broad concentration range of IL-6 in a representative panel of HNSCC cells. Secondary antibodies (Ab2) attached to carboxylated multiwall carbon nanotubes with 106 HRP labels per 100 nm gave the highest sensitivity of 19.3 nA mL (pg IL-6)−1 cm−2 and the best detection limit (DL) of 0.5 pg mL−1 (25 fM) for IL-6 in 10 μL of calf serum. For more concentrated samples, biotinylated Ab2 bound to streptavidin-HRP to provide 14−16 labels per antigen was used. These immunosensors accurately measured secreted IL-6 in a wide range of HNSCC cells demonstrated by excellent correlations with standard enzyme-linked immunosorbent assays (ELISA), suggesting that SWNT immunosensors combined with multilabel detection have excellent promise for detecting IL-6 in research and clinical applications

Ultrasensitive Immunosensor for Cancer Biomarker Proteins Using Gold Nanoparticle Film Electrodes and Multienzyme-Particle Amplification

A densely packed gold nanoparticle platform combined with a multiple-enzyme labeled detection antibody-magnetic bead bioconjugate was used as the basis for an ultrasensitive electrochemical immunosensor to detect cancer biomarkers in serum. Sensitivity was greatly amplified by synthesizing magnetic bioconjugates particles containing 7500 horseradish peroxidase (HRP) labels along with detection antibodies (Ab2) attached to activated carboxyl groups on 1 μm diameter magnetic beads. These sensors had sensitivity of 31.5 μA mL ng−1 and detection limit (DL) of 0.5 pg mL−1 for prostate specific antigen (PSA) in 10 μL of undiluted serum. This represents an ultralow mass DL of 5 fg PSA, 8-fold better than a previously reported carbon nanotube (CNT) forest immunosensor featuring multiple labels on carbon nanotubes, and near or below the normal serum levels of most cancer biomarkers. Measurements of PSA in cell lysates and human serum of cancer patients gave excellent correlations with standard ELISA assays. These easily fabricated AuNP immunosensors show excellent promise for future fabrication of bioelectronic arrays

Supplementary Figure 1 from Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model

Supplementary Figure 1 from Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Mode