Hikeshi で制御されるヒトHeLa 細胞とヒト不死化網膜上皮細胞のストレス応答機構の解析

学位記号番号 : 博理工乙第243号博士の専攻分野の名称 : 博士(理学) 学位授与年月日 : 平成30年3月23日textapplication/pdfthesi

地域イノベーションと現場改善

departmental bulletin pape

Observation of B+→pp̅π+, B0→pp̅K0, and B+→pp̅K*+

journal articl

STATIONARY RANDOM MEASURES AND RENEWAL THEORY

application/pdfdepartmental bulletin pape

mariana

Rhexia mariana L. var. marianaMaryland meadowbeautyRhexia delicatulaAlabama Mts

論理法学とオンラインADR

2008-12-15departmental bulletin pape

研究速報 : CGTを用いた自動車用ハイブリッドシステムの走行性能評価

departmental bulletin pape

A decision support framework for sustainable highway alignment embracing variant preferences of stakeholders: case of China Pakistan economic corridor

The selection of highway alignment without explicit consideration of the interests and preferences of stakeholders is a major recipe for conflicts and opposition in highway projects. Given the complex and dynamic nature of the highway alignment decision atmosphere, a dynamic framework is imperative. This research evaluated three multi-criteria decision methods (MCDMs), identified the optimal combination and proposed a highway alignment decision support framework which embraces the preferences of stakeholders. The proposed framework was validated using a controversial ongoing mega highway project from the China Pakistan Economic Corridor (CPEC). Thus, the study makes a useful contribution to the praxis and practice of the highway alignment decision-making process.</p

Fabrication of Epigallocatechin-3-gallate Nanocarrier Based on Glycosylated Casein: Stability and Interaction Mechanism

Polyphenols normally have strong binding affinity with proteins, which may lead to protein precipitation. Glycosylation of protein via Maillard reaction in mild condition may inhibit the precipitation. This study prepared nanocomplexes of epigallocatechin-3-gallate (EGCG) and protein, and their stability against environmental stress was investigated. Subsequently, these findings were correlated with the interactions between EGCG and casein. Results showed that glycosylated casein displayed strong encapsulating and retaining capacity to EGCG, and no obvious aggregation or fusion appeared in the concentration range of 0.25–5.00 mg/mL during storage. The in vitro release demonstrated that casein, especially glycosylated casein, could effectively protect EGCG from degradation in alkaline pH and displayed a slow and sustained release in intestinal fluid, which may be attributed to the inhibiting effects of casein binding on the motion freedom of EGCG. Fluorescence quenching spectra demonstrated that the steric hindrance induced by dextran could inhibit the interaction between casein and EGCG. These findings demonstrated that glycosylated casein could be used as a promising and effective nanocarrier for EGCG

DataSheet1_Study on structure optimization and applicability of hydrocyclone in natural gas hydrate exploitation.docx

With the development of economy and industry, the consumption of fossil energy is gradually increasing. Currently, natural gas hydrates (NGH) are considered to be an ideal alternative energy due to its large reserve and high energy density. However, the separation of hydrate slurry is a critical step in the exploitation of NGH. In this study, the optimization of the structural parameters based on the conventional three-phase hydrocyclone was carried out using numerical simulation and orthogonal design. At the same time, the separation efficiency criterion E was defined to evaluate the separation efficiency by calculating the sum of the discharge efficiency of water and gas. Analysis of the effect of individual structural factors on the flow field distribution characteristics inside the hydrocyclone using the single factor analysis method. The results showed that: with the combination of structural parameters of s was 2 mm2 × 12 mm2, dz was 28 mm, h was 20 mm, and li was 28 mm, the maximum E of the three-phase hydrocyclone was 1.46. The effect significance of each structural parameter on the separation efficiency from the highest to the lowest was the s, dz, h, and li. In the single-factor analysis, when the s was 2 mm2 × 12 mm2, the tangential velocity, axial velocity, and CH4 volume fraction in the flow field reached the maximum of 13.65 m/s, 4.35 m/s, and 12.4%, respectively. But the minimum water phase volume fraction was 69.9% under this structural parameter condition. When the dz was 36 mm, the maximum decrease value of axial velocity in the flow field was 3.57 m/s, the maximum CH4 volume fraction was 12.4%, and the water volume fraction reached a minimum of 66.3%. The li and the h only had significant effects on the axial velocity and the water volume fraction, respectively. The axial velocity reached a maximum of 4.75 m/s when the li was 32 mm, and the water phase volume fraction reached a maximum of 77.9% when the h was 10 mm. The study of the structural parameters and flow field characteristics of this three-phase hydrocyclone applicable to the solid fluidization exploitation of NGH provides some guidance and suggestions for the separation of hydrate slurry after solid fluidization exploitation of NGH.</p