地盤・基礎・構造物系の地震時相互作用～解析法と耐震設計への導入～

research repor

動力学の基礎と応用 ～建設・機械工学系の技術者のための～

research repor

Observation of B+→pp̅π+, B0→pp̅K0, and B+→pp̅K*+

journal articl

SINGULAR SOLUTIONS OF ORDINARY DIFFERENTIAL EQUATIONS

application/pdfdepartmental bulletin pape

わが国における主催(パック)旅行契約の基本的枠組み ―旅行契約に関する国際協定(ブリュッセル協定)を参考に

2008-12-15departmental bulletin pape

Toward biotherapeutic product real-time quality monitoring

Biotherapeutics, such as those derived from monoclonal antibodies (mAbs), are industrially produced in controlled multiunit operation bioprocesses. Each unit operation contributes to the final characteristics of the bioproduct. The complexity of the bioprocesses, the cellular machinery, and the bioproduct molecules, typically leads to inherent heterogeneity and variability of the final critical quality attributes (CQAs). In order to improve process control and increase product quality assurance, online and real-time monitoring of product CQAs is most relevant. In this review, the recent advances in CQAs monitoring of biotherapeutic drugs, with emphasis on mAbs, and throughout, the different bioprocess unit operations are reviewed. Recent analytical techniques used for assessment of product-related CQAs of mAbs are considered in light of the analytical speed and ability to measure different CQAs. Furthermore, the state of art modeling approaches for CQA estimation in real-time are presented as a viable alternative for real-time bioproduct CQA monitoring under the process analytical technology and quality-by-design frameworks in the biopharmaceutical industry, which have recently been demonstrated.</p

Effect of inorganic salts on bacterial omega-3 PUFA production

<p>The increasing demand of omega-3 in the market and the challenges facing its conventional supplies led to an increasing interest to microbial omega-3 sources. This research concentrates on the statistical role of some metal ions on the biosynthesis and productivity of eicosapentaenoic acid (essential omega-3 element) in bacterial isolate, <i>Shewanella</i> 717. A Plackett–Burman design was applied to screen the main effect of all metal salts entrenched in the artificial sea water medium components. Four salts, in particular, in addition to the interaction among them were highlighted as having a statistically significant effect upon the growth and/or eicosapentaenoic acid production. A subsequent central composite design was performed to determine the exact optimum concentration of each of the chosen variables which was found to be 2.5, 1.8, 1.2, and 23 g/l, for Na₂HPO₄, MgSO₄, KCl, and NaCl, respectively. All the experiments were performed with the minimal amount of carbon and nitrogen to eliminate any potential masking effect. A bioreactor batch run was operated and the ion uptake was monitored, using EDAX® electron microscopy, concluding that the process of microbial omega-3 production could be a phosphate-limited process. Optimizing the concentration of the tested metal ions led to a remarkable increase in the omega-3 productivity resulted in a 30, 9, and 10 times increase in yield, concentration, and percentage to the total fatty acids, respectively, even though the carbon and nitrogen were kept constant all over the research work.</p

研究速報 : Monolithically Integrated Diode Laser Detection System for Scanning Near-Field Optical Microscopy (SNOM) : VCSEL Technology

departmental bulletin pape

Numerical simulation of ground motions and damage of bridge in near field of the 2016 Kumamoto earthquake fault

This paper investigates the consequences of so called fling-step characteristics of near-field ground motions, which is originated by the permanent ground deformations due to a fault, on the damage of bridge caused by the 2016 Kumamoto earthquake （MJMA 7.3）. To simulate ground motions including permanent displacements, the stiffness matrix method is used and the fibre element method is adopted to compute the 3D nonlinear responses of a bridge. It is found from the study that recorded ground motions and the bridge damages can be fmely simulated

Tsunami Flood Prediction and Its Application of Mitigation of an Industrial Factory using Wide Scale 3D Simulation

一般的に、津波シミュレーションには、平面二次元津波解析が用いられている。これに対して、高精度な三次元津波解析は、膨大な計算時間を必要とするため、ほとんど使用されていない。本研究では、正確に工場内の津波浸水状況と施設への波力等の津波の影響を予測し、適切な対策を実施するため、ハイブリッドモデルによる高精度な広域三次元津波シミュレーションを実施した。このハイブリッドモデルは,平面二次元津波解析と三次元津波解析を組合せたものであり、波源域から対象地点の工場までの領域に対して、効率よく津波シミュレーションが行える。さらに、本シミュレーションを用いて、工場内の浸水状態を予測するだけでなく、重要施設への津波浸水対策等についても検討した。Generally, two-dimensional tsunami analysis is used for the tsunami simulation. On the other band, since huge computation time is needed, highly precise three-dimensional tsunami analysis is not usually used. In this study, the highly precise wide scale three-dimensional tsunami simulation has been carried out by the hybrid model in order to predict correctly the tsunami flood situation in af actory. This hybrid model combines two-dimensional tsunami analysis and three-dimensional tsunami analysis, and can perform a tsunami simulation efficiently from a wave source region to the factory of an object point. Moreover, the effect of the mitigation methods have been showed concretely against tsunami flood of impotant industrial factory using this simulation