Error Performance of Rectangular Pulse-shaped OTFS with Practical Receivers

application/pdfIEEE Wireless Communications Letters. 2022, 11 (12), P.2690-2694journal articl

鉄鋼材料破壊靱性のメゾメカニックス的解析

名古屋大学Nagoya University博士(工学)名古屋大学博士学位論文 学位の種類:博士(工学) (課程) 学位授与年月日:平成17年3月25日doctoral thesi

たばこ煙の充填層濾過ならびに性状と成分組成の評価に関する研究

学位記号番号 : 博理工甲第1106号博士の専攻分野の名称 : 博士(工学) 学位授与年月日 : 平成30年9月21日textapplication/pdfthesi

English Instruction and the Formation of Future Self Image : Activities Integrating Second Language and Visual Art Learning Practices

departmental bulletin pape

Observation of B+→pp̅π+, B0→pp̅K0, and B+→pp̅K*+

journal articl

DEHN'S SURGERY ALONG 2-BRIDGE KNOTS

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HER2 Targeted Breast Cancer Therapy with Switchable “Off/On” Multifunctional “Smart” Magnetic Polymer Core–Shell Nanocomposites

Multifunctional magnetic polymer nanocombinations are gaining importance in cancer nanotheranostics due to their safety and their potential in delivering targeted functions. Herein, we report a novel multifunctional core–shell magnetic polymer therapeutic nanocomposites (NCs) exhibiting pH dependent “Off–On” release of drug against breast cancer cells. The NCs are intact in blood circulation (“Off” state), i.e., at physiological pH, whereas activated (“On” state) at intracellular acidic pH environment of the targeted breast cancer cells. The NCs are prepared by coating the cannonball (iron nanocore) with hydrophobic nanopockets of pH-responsive poly­(d,l-lactic-<i>co</i>-glycolic acid) (PLGA) polymer nanoshell that allows efficient loading of therapeutics. Further, the nanocore–polymer shell is stabilized by poly­(vinylpyrrolidone) (PVP) and functionalized with a targeting HER2 ligand. The prepared Her–Fe₃O₄@PLGA–PVP nanocomposites facilitate packing of anticancer drug (Tamoxifen) without premature release in the bloodstream, recognizing the target cells through binding of Herceptin antibody to HER2, a cell surface receptor expressed by breast cancer cells to promote HER2 receptor mediated endocytosis and finally releasing the drug at the intracellular site of tumor cells (“On” state) to induce apoptosis. The therapeutic efficiency of hemo/cytocompatible NCs drug delivery system (DDS) in terms of targeted delivery and sustained release of therapeutic agent against breast cancer cells was substantiated by <i>in vitro</i> and <i>in vivo</i> studies. The multifunctional properties of Her–Tam–Fe₃O₄@PLGA–PVP NCs may open up new avenues in cancer therapy through overcoming the limitations of conventional cancer therapy

研究速報 : シリコンマイクロマシニングによるステップアクチュエータ

departmental bulletin pape