「ケア」と健康の連結を考える

departmental bulletin pape

A Practical Report of Growing Students Who Acquire Literacy by Themselves.

departmental bulletin pape

Observation of the DsJ(2317) and DsJ(2457) in B Decays

journal articl

BAHADUR-TYPE REPRESENTATION OF SAMPLE CONDITIONAL QUANTILES BASED ON WEAKLY DEPENDENT DATA

application/pdfBahadur-type representations of nearest-neighbor and kernel estimators of the conditional ＄P＄-quantile ＄￥theta_{p}(x)＄ are obtained when the sample forms a strictly stationary absolutely regular sequence of two dimensional random vectors.departmental bulletin pape

超音波診断装置による筋の定量的評価

(測定・評価)journal articl

Study on Wear Estimation and Wear Reduction of the Floating Offshore Wind Observation System "Buoy Lidar"

日本船舶海洋工学会論文集. 2023, 37, P.27-36journal articl

New Tricyclic Sesquiterpenes from the Fermentation Broth of <i>Stereum </i><i>h</i><i>irsutum</i>

In search for novel metabolites from the culture broth of the mushroom Stereum hirsutum, three new tricyclic sesquiterpenes named hirsutenols A (1), B (2), and C (3) have been isolated. Their structures were assigned on the basis of various spectroscopic studies

Development of Dynamic Model of Wave Energy Converters Using Gaussian Process Regression

日本船舶海洋工学会論文集. 2023, 38, P.117-125journal articl

Chemical Constituents of the Culture Broth of <i>Panus rudis</i>

In our ongoing search for new secondary metabolites from fungal strains, one novel compound (1) and nine known compounds (2-10) were isolated from the EtOAc-soluble layer of the culture broth of Panus rudis. The culture broth of P. rudis was extracted in acetone and fractionated by solvent partition; column chromatography using silica gel, Sephadex LH-20, and Sephadex G-10; MPLC; and HPLC. The structures of isolated compounds were elucidated by one- and two-dimensional NMR and LC-ESI-mass measurements. One new compound, panepoxydiol (1), and nine known compounds, (E)-3-(3-hydroxy-3-methylbut-1-en-1-yl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol (2), isopanepoxydone (3), neopanepoxydone (4), panepoxydone (5), panepophenanthrin (6), 4-hydroxy-2,2-dimethyl-6-methoxychromane (7), 6-hydroxy-2,2-dimethyl-3-chromen (8), 2,2-dimethyl-6-methoxychroman-4-one (9), 3,4-dihydroxy-2,2-dimethyl-6-methoxychromane (10), were isolated from the culture broth of P. rudis. This is the first report of isolation of a new compound panepoxydiol (1) and nine other chemical constituents (2-5, 7-10) from the culture broth of P. rudis.</p

Neuraminidase Inhibitors from the Fruiting Body of <i>Glaziella splendens</i>

Neuraminidase (NA) cleaves the glycosidic bond linkages of sialic acids to release the mature virions from infected cells and has been an attractive therapeutic target for anti-influenza agents. In our ongoing investigation of NA inhibitors in mushroom extracts, we found that the extract the fruiting body of Glaziella splendens potently inhibited neuraminidase. The fruiting bodies of G. splendens were extracted and partitioned successively with hexane, ethyl acetate, and butanol. The ethyl acetate soluble-layer was subjected to silica gel and Sephadex LH-20 column chromatographies, and MPLC to obtain five compounds (1–5). Their structures were determined by spectroscopic methods. NA inhibitory activity of these compounds was evaluated using NAs from recombinant rvH1N1, H3N2, and H5N1 influenza A viruses. One compound (1) was elucidated as a new azaphilone derivative, and four compounds (2–5) were identified as entonaemin A, comazaphilone D, rubiginosin A, and entonaemin B, respectively. Compounds 3 and 4 showed considerable inhibitory activity against three types of neuraminidases with the IC50 values of 30.9, 41.8, and 35.7 µM for 3 and 46.5, 50.4, and 29.9 µM for 4, respectively. This study reveals that the fruiting bodies of G. splendens possess azaphilone derivatives with the NA inhibitory activity. This is the first report on the isolation of neuraminidase inhibitors from the fruiting bodies of G. splendens.</p